Neurotensin: dual roles in psychostimulant and antipsychotic drug responses.

abstract：AIMS:Tetramethylpyrazine (TMP), one of the active ingredients isolated from a Chinese herbal prescription, possesses protective effects against oxidative stress caused by high glucose in endothelial cells. In this study, the role of TMP in preventing muscle cells from palmitate-induced oxidative damage was investigated...

journal_title：Life sciences

authors： Gao X,Zhao XL,Zhu YH,Li XM,Xu Q,Lin HD,Wang MW

更新日期：2011-04-25 00:00:00

abstract：AIMS:Osteosarcoma is one of the most aggressive types of primary bone cancer that responds poorly to radiotherapy frequently. The gene associated with retinoid-interferon mortality (GRIM-19) is a tumor suppressor that mediates cell apoptosis in multiple cancer types. However, the role of GRIM-19 in osteosarcoma and the...

journal_title：Life sciences

authors： Chen W,Liu Q,Fu B,Liu K,Jiang W

更新日期：2018-09-01 00:00:00

abstract：:The role of p44/42 mitogen-activated protein kinase (MAPK) in the expression of intercellular adhesion molecule-1 (ICAM-1) in NCI-H292 cells, a human bronchial epithelial cell line, was analyzed. Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamm...

journal_title：Life sciences

authors： Shibuya Y,Hirasawa N,Sakai T,Togashi Y,Muramatsu R,Ishii K,Yamashita M,Takayanagi M,Ohuchi K

更新日期：2004-06-11 00:00:00

abstract：UNLABELLED:Acute exercise is a stress stimulus that may cause cell damage through the activation of the toll-like receptor (TLR)4 pathway, resulting in the translocation of nuclear factor kappa B (NF-κB) into the cell nucleus and the upregulation of inflammatory genes. Nonsteroidal anti-inflammatory drugs, such as dicl...

journal_title：Life sciences

authors： Barcelos RP,Bresciani G,Rodriguez-Miguelez P,Cuevas MJ,Soares FA,Barbosa NV,González-Gallego J

更新日期：2016-03-01 00:00:00

abstract：AIMS:Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS:Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h ...

journal_title：Life sciences

authors： Stein T,Tonussi CR

更新日期：2020-12-01 00:00:00

abstract：:Loperamide effects on hepatobiliary function, analgesia and gut transit were studied in mice. Varying doses of the antidiarrheal drug, loperamide, were administered to mice by intracerebroventricular, intravenous, subcutaneous and intragastric routes. Gut motility was determined by intestinal transit of India ink, ana...

journal_title：Life sciences

authors： Hurwitz A,Sztern MI,Looney GA,Ben-Zvi Z

更新日期：1994-01-01 00:00:00

abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...

journal_title：Life sciences

authors： Cui YL,Xue RQ,Xi He,Ming Zhao,Yu XJ,Liu LZ,Wu Q,Si Yang,Li DL,Zang WJ

更新日期：2019-04-01 00:00:00

abstract：:This paper demonstrates marked differences between blood levels and those in the CSF for three anterior pituitary peptide hormones, prolactin, luteinizing hormone (LH) and adrenocorticotrophin (ACTH) in the rhesus monkey. CSF levels of endogenous prolactin (measured by radioimmunoassay) are about 20% of those in the b...

journal_title：Life sciences

authors： Dubey AK,Herbert J,Martensz ND,Beckford U,Jones MT

更新日期：1983-04-18 00:00:00

abstract：:This study examined the role of marijuana smoking in the pathogenesis of human lung cancer by measuring DNA damage in alveolar macrophages (AM). The alkaline unwinding method was used to determine DNA single-strand breaks in AM lavaged from non-smokers [NS] and smokers of marijuana [MS], tobacco [TS] or cocaine [CS], ...

journal_title：Life sciences

authors： Sherman MP,Aeberhard EE,Wong VZ,Simmons MS,Roth MD,Tashkin DP

更新日期：1995-01-01 00:00:00

abstract：:The effect of maternal glucocorticoid depletion upon the fetal development of the organ of Zuckerkandl (OZ) in rats was determined. Maternal hypophysectomy at 13d8h gestation resulted in a fifty percent decrease in plasma corticosterone levels at 18d8h when compared to both sham operated and unoperated controls. No di...

journal_title：Life sciences

authors： Peters LL,Wood BG

更新日期：1987-09-14 00:00:00

abstract：:Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...

journal_title：Life sciences

authors： Kuo YC,Tsai WJ,Wang JY,Chang SC,Lin CY,Shiao MS

更新日期：2001-01-19 00:00:00

abstract：:10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

journal_title：Life sciences

authors： Szalay KS

更新日期：1993-01-01 00:00:00

abstract：:The effects of eight catechin derivatives on vascular tone in rat thoracic aorta were examined. Catechin derivatives (10 microM) potentiated the contractile response to phenylephrine in endothelium-intact arteries. The potentiations produced by EGCg and EGC were almost absent in endothelium-denuded arteries and abolis...

journal_title：Life sciences

authors： Sanae F,Miyaichi Y,Kizu H,Hayashi H

更新日期：2002-10-11 00:00:00

abstract：:Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...

journal_title：Life sciences

authors： Crowe TP,Greenlee MHW,Kanthasamy AG,Hsu WH

更新日期：2018-02-15 00:00:00

abstract：:Besides an isomer of the cardenolide ouabain, a material with a similar HPLC retention time as ouabain but cross-reactivating with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump is known to circulate in human blood plasma (B. SICH et al., Hypertension 27, 1073-1078 (1996).). The c...

journal_title：Life sciences

authors： Li S,Eim C,Kirch U,Lang RE,Schoner W

更新日期：1998-01-01 00:00:00

abstract：:The new Coronavirus (SARS-CoV-2) is the cause of a serious infection in the respiratory tract called COVID-19. Structures of the main protease of SARS-CoV-2 (Mpro), responsible for the replication of the virus, have been solved and quickly made available, thus allowing the design of compounds that could interact with ...

journal_title：Life sciences

authors： Hage-Melim LIDS,Federico LB,de Oliveira NKS,Francisco VCC,Correia LC,de Lima HB,Gomes SQ,Barcelos MP,Francischini IAG,da Silva CHTP

更新日期：2020-09-01 00:00:00

abstract：:Reports indicate that the administration of tyrosine, the precursor amino acid for catecholaminergic neurotransmitters, may be beneficial under conditions of physiologic stress. We studied the effects of tyrosine on vulnerability to ventricular arrhythmia in conscious pigs with healing myocardial infarcts, and sham op...

journal_title：Life sciences

authors： Pinto JM,Kirby DA,Maher TJ,Lown B

更新日期：1991-01-01 00:00:00

abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...

journal_title：Life sciences

authors： Hirayama N,Kitamura K,Imamura T,Kato J,Koiwaya Y,Eto T

更新日期：1999-01-01 00:00:00

abstract：:The effects of the d- and l-isomers of pentazocine were compared to that of racemic pentazocine on contractions of the mouse isolated vas deferens. L-pentazocine inhibited electrically evoked contractions of the mouse vas deferens (MVD) in a dose-dependent manner (ID50 0.37 +/- 0.04 microM). In contrast, d-pentazocine...

journal_title：Life sciences

authors： Kinouchi K,Fukumitsu K,Takezawa J,Maeda S,Enomoto H,Kakuhari J,Yoshiya I,Inoki R

更新日期：1986-07-14 00:00:00

abstract：:Sweat glands are innervated by sympathetic neurons which undergo a change in transmitter phenotype from noradrenergic to cholinergic during development. As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the absence of innervation ...

journal_title：Life sciences

authors： Landis SC

更新日期：1999-01-01 00:00:00

abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...

journal_title：Life sciences

authors： Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SA

更新日期：2020-04-15 00:00:00

abstract：AIMS:We investigated whether cAMP-mediated protein kinase A(PKA) and Epac1/Rap1 pathways differentially affect brain tumor cell death using 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone(rolipram), specific phosphodiesterase type IV(PDE IV) inhibitor. MAIN METHODS:A172 and U87MG human glioblastoma cells were used....

journal_title：Life sciences

authors： Moon EY,Lee GH,Lee MS,Kim HM,Lee JW

更新日期：2012-02-27 00:00:00

abstract：:The biosynthesis of phospholipids during differentiation of normal and dystrophic muscle cells was studied using [32Pi] added to primary culture media. Labeled phosphatides were separated by two-dimensional thin-layer chromatography, exposing the plates to HCl vapors between solvents to cleave the alk-1-enyl bonds. Ph...

journal_title：Life sciences

authors： Leskawa KC,Erwin RE,Hogan EL

更新日期：1986-01-13 00:00:00

abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...

journal_title：Life sciences

authors： Szebeni J,Garcia R,Eskelson CD,Chvapil M

更新日期：1989-01-01 00:00:00

abstract：:The use of neuroleptic drugs to treat schizophrenia is almost invariably associated with extrapyramidal movement disorders. One of these disorders, tardive dyskinesia (TD), can persist long after neuroleptic withdrawal suggesting that permanent neurological damage is produced. However, there appears to be no convincin...

journal_title：Life sciences

authors： Eyles DW,Pond SM,Van der Schyf CJ,Halliday GM

更新日期：2000-02-25 00:00:00

abstract：OBJECTIVE:To estimate the alterations of paraoxonase 1 (PON1) and high-density lipoprotein (HDL) in rheumatoid arthritis (RA). DESIGN AND METHODS:We investigated the serum enzyme activity and concentration of PON1 and their relationship with serum lipids, high-density lipoprotein (HDL) parameters, and acute phase reac...

journal_title：Life sciences

authors： Tanimoto N,Kumon Y,Suehiro T,Ohkubo S,Ikeda Y,Nishiya K,Hashimoto K

更新日期：2003-05-09 00:00:00

abstract：AIMS:Systemic administration of opiate analgesics such as morphine remains the most effective treatment for alleviating severe pain across a range of conditions including acute pain. However, chronic or repeated administration of opiate analgesics results in the development of analgesic tolerance. Glial cells such as m...

journal_title：Life sciences

authors： Harada S,Nakamoto K,Tokuyama S

更新日期：2013-10-11 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS), X-linked severe combined immunodeficiency (SCIDX1), and X-linked agammaglobulinemia (XLA) are severe congenital immunodeficiencies with X-linked inheritance. Although rare, they are all associated with severe infections from early in life, and high morbidity and mortality. Female ca...

journal_title：Life sciences

authors： Wengler GS,Parolini O,Fiorini M,Mella P,Smith H,Ugazio AG,Notarangelo LD

更新日期：1997-01-01 00:00:00

abstract：:The intracellular ionic content of human erythrocytes may be altered by hyperglycaemia. Despite this, very little is known about the cellular mechanisms linking glucose and cellular magnesium homeostasis. We measured intracellular ionized magnesium in human lymphocytes, by means of a fluorimetric technique, total intr...

journal_title：Life sciences

authors： Delva P,Degan M,Pastori C,Faccini G,Lechi A

更新日期：2002-09-20 00:00:00

abstract：:Decidualization of endometrial tissues, which is essential for implantation and the continuation of pregnancy, is induced by pituitary hormones that are regulated by gonadotropin releasing hormone (GnRH). Our objective was to determine the role of a direct action of GnRH on endometrial tissues by comparing the charact...

journal_title：Life sciences

authors： Takeuchi S,Futamura N,Minoura H,Toyoda N

更新日期：1998-01-01 00:00:00