Abstract:
AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against isoproterenol-induced acute MI (A-MI) under hypercholesterolemic conditions in rats. MAIN METHODS:Dietary hypercholesterolemic rats were subjected to acute doses of isoproterenol. Serum lipids, inflammatory markers, aortic endothelin1 and endothelial nitric oxide synthase (eNOS) mRNAs expression and immunexpression of BCL2 were determined. KEY FINDINGS:Hypercholesterolemic rats showed infiltration of inflammatory cells and reduction in aortic wall thickness, deposition of fibrous tissue between cardiac muscle fibers. Protective doses of prasugrel or clopidogrel for 28 days before A-MI increased survival, amended the ECG parameters -including ST segment elevation- and improved the histopathological picture in hypercholesterolemic rats. This was coupled with reductions in platelet aggregation, creatine kinase-MB activity, endothelin 1, systemic inflammation and cardiac lipid peroxidation and increment in aortic eNOS expression. Clopidogrel and prasugrel groups showed enhanced BCL2 expression in cardiac fibers and aortic wall. SIGNIFICANCE:Prasugrel and clopidogrel protected against A-MI via anti-aggregatory and anti-inflammatory effects. These results add to the value of these drugs in correcting cardiovascular dysfunction in patients vulnerable to A-MI after confirmation by appropriate human studies.
journal_name
Life Scijournal_title
Life sciencesauthors
Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SAdoi
10.1016/j.lfs.2020.117429subject
Has Abstractpub_date
2020-04-15 00:00:00pages
117429eissn
0024-3205issn
1879-0631pii
S0024-3205(20)30176-4journal_volume
247pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The pineal gland hormone melatonin is now considered an important neuroendocrine component of animal physiology. Although the functional status of melatonin has been well described for subhuman species, there is a paucity of data concerning the physiological role of this hormone in man. This paucity of data has much t...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(89)90262-2
更新日期:1989-01-01 00:00:00
abstract::The prototypic arylpiperazines, meta-chlorophenylpiperazine (mCPP), meta-trifluoromethylphenylpiperazine (TFMPP) and quipazine are widely studied serotonergic ligands with nonselective effects at 5HT1 and 5HT2 receptor subtypes. The present study was designed to compare the affinities of these arylipiperazines at 5HT3...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90372-v
更新日期:1992-01-01 00:00:00
abstract::Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.01.016
更新日期:2016-08-15 00:00:00
abstract::A time course study on the effects of an interferon inducing agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed. Administration of a single dose of poly rIrC (10 mg/kg i.p.) to adult male Wistar rats caused a time dependent effect ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90029-3
更新日期:1993-01-01 00:00:00
abstract::The present study examined the discriminative stimulus and response rate-decreasing effects of kappa opioids in pigeons trained to discriminate a 0.017 mg/kg dose of bremazocine from saline. Bremazocine, spiradoline, CI977, U69,593 and U50,488 substituted completely for the bremazocine stimulus in a dose-dependent and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90115-5
更新日期:1994-01-01 00:00:00
abstract::Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.03.011
更新日期:2008-05-23 00:00:00
abstract::The effects of methyl vitamin B12 (5-6 mg/kg, p.o.) on the entrainment of circadian running wheel activity rhythm to a new lighting schedule were measured in rats. After the light-dark (LD) cycle was abruptly reversed, rats given vitamin B12 took less time to entrain their circadian locomotor activity rhythm to the ne...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90544-y
更新日期:1992-01-01 00:00:00
abstract::Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90248-5
更新日期:1983-08-15 00:00:00
abstract::Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2) was most strongly affected (50% inhibition at 3 mM phenobarbital); p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90530-3
更新日期:1987-11-02 00:00:00
abstract::Trichosanthin (TCS) is a type 1 ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infection affect the phosphorylation of MAPK and Bcl-2 and these protein...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.03.047
更新日期:2006-08-22 00:00:00
abstract:AIM:Preparation of pegylated gold nanorods (PEG-AuNRs) that are capable of converting near infrared (NIR) light into heat. Evaluation of cancer therapeutic efficacy and long-term toxicity of the proposed photothermal therapy in comparison with other conventional modalities. MATERIALS AND METHODS:Prepared PEG-AuNRs wer...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118108
更新日期:2020-09-15 00:00:00
abstract:AIMS:The aim of the study was to identify key miRNAs related to hepatocellular carcinoma (HCC) and then to explore their potential function and clinical significance. MATERIALS AND METHODS:The miRNA expression profiles of 387 HCC and 62 normal liver tissues were obtained from the Gene Expression Omnibus (GEO) and The ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116596
更新日期:2019-09-01 00:00:00
abstract::Amylin is co-secreted with insulin from the pancreas of patients with non-insulin dependent diabetes mellitus, and its deposition may contribute to the central nervous system (CNS) manifestations of this disease. Amylin, but not its mRNA, is found in brain, suggesting that CNS amylin is derived from the circulation. T...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02197-q
更新日期:1995-01-01 00:00:00
abstract:AIMS:Insulinoma-associated protein 2β (IA-2β) is considered to play a significant role in regulated secretion. Recent studies have shown that the mouse brain expresses three major isoforms of IA-2β, named IA-2β60, IA-2β64, and IA-2β71. In this study, we analyzed the tissue-, cell- and organelle-specific distributions o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.02.018
更新日期:2011-04-25 00:00:00
abstract:AIMS:Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.008
更新日期:2016-07-15 00:00:00
abstract::The feasibility of using human cells isolated from peritoneal dialysis effluent as a model for studying lipoprotein and cholesterol metabolism was investigated. Human peritoneal cells degraded low density lipoproteins (LDL) and acetylated LDL (acetyl-LDL) by saturable, high affinity receptor-mediated processes. Positi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00138-5
更新日期:1996-01-01 00:00:00
abstract::This investigation was designed to determine whether St. John's wort (SJW)(435 mg/kg/d), a readily available antidepressant, or its purported active constituents hypericin (1 mg/kg/d) and hyperforin (10 mg/kg/d) were able to induce various hepatic cytochrome P450 (CYP450) isoforms. SJW, hypericin and hyperforin were a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01499-0
更新日期:2002-02-01 00:00:00
abstract::Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90140-8
更新日期:1987-01-26 00:00:00
abstract::Unfertilized ova from Shad, a North Atlantic herring, contains a cytostatic inhibitor of T lymphocyte blastogenesis. The inhibitor has an estimated molecular weight of 10,000-30,000 Da, is heat stable, non dialyzable, and resistant to protease digestion and periodate oxidation. Although the inhibitor functions at an e...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90336-p
更新日期:1990-01-01 00:00:00
abstract::DCLHb, a hemoglobin based oxygen carrier, has been extensively studied for the treatment of hemorrhagic shock in both animal models and humans. Numerous accidents resulting in trauma are due to ethanol intoxication, in particular cases of car accidents. Therefore, trauma patients might be intoxicated with drugs of abu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)01040-7
更新日期:2001-02-09 00:00:00
abstract:UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01411-4
更新日期:2001-11-09 00:00:00
abstract::Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90609-f
更新日期:1991-01-01 00:00:00
abstract::Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90333-5
更新日期:1988-01-01 00:00:00
abstract::We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measure...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.03.011
更新日期:2005-07-29 00:00:00
abstract::L-dopa is the major treatment for Parkinson's disease (PD), but its efficacy is limited by the presence of dyskinesia. The dyskinesia develops over a period of exposure to L-dopa and is related to the dosage, therefore, the cause may involve inductive changes that produce toxic levels of metabolites, interfering with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00543-9
更新日期:2000-04-21 00:00:00
abstract::Certain pharmacological properties of methyl beta-carboline-3-carboxylate (beta-CCM), a benzodiazepine receptor ligand, have been investigated in chicks. Although beta-CCM has been established previously as an "inverse agonist" of benzodiazepine receptors in rodents, having effects opposite to those of benzodiazepines...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90201-8
更新日期:1986-09-22 00:00:00
abstract::The platelet activating factor (PAF) receptor of the guinea pig peritoneal eosinophil was characterized by radioligand ([3H]WEB 2086) binding and measurement of PAF-stimulated membrane GTPase activity. Specific binding of [3H]WEB 2086 was rapid, reversible and saturable, with an equilibrium KD of 20.4 nM at 0 degrees ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90045-5
更新日期:1993-01-01 00:00:00
abstract::We report the presence of p-fluorophenylglycine (p-FPG) in the urine of six baboons treated with HPTP, the tetrahydropyridine dehydration product of haloperidol (HP). Oxidative N-dealkylation, the major metabolic pathway of HP, gives rise to 3-(4-fluorobenzoyl)propionic acid (p-FBPA). Subsequent beta-oxidation of p-FB...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00274-x
更新日期:1999-01-01 00:00:00
abstract::Acyl glucuronides are reactive electrophilic metabolites of carboxylate drugs, capable of undergoing hydrolysis, rearrangement and covalent binding reactions with proteins in vivo. Such covalent drug-protein adducts may be prerequisites for certain idiosyncratic immune and toxic responses in susceptible individuals. T...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00958-9
更新日期:2000-12-22 00:00:00
abstract:OBJECTIVE:This study aims to evaluate the effective of azoles and MTX for patients with invasive candidiasis. METHODS:We used the disk diffusion assay and the checkerboard assay to evaluate the in vitro interactions between MTX and antifungals. In addition, we used the transmission electron microscopy to observe the u...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116827
更新日期:2019-10-15 00:00:00