An inhibitor of T lymphocyte blastogenesis derived from the unfertilized ova of Shad (Alosa sapidissima).

Abstract:

:Unfertilized ova from Shad, a North Atlantic herring, contains a cytostatic inhibitor of T lymphocyte blastogenesis. The inhibitor has an estimated molecular weight of 10,000-30,000 Da, is heat stable, non dialyzable, and resistant to protease digestion and periodate oxidation. Although the inhibitor functions at an early metabolic event in T lymphocyte mitogenesis, it does not appear to interfere with thymidine transport, antagonize lectin binding to lymphocyte surface receptors, or interfere with the function of an essential serum component in the cell culture media.

journal_name

Life Sci

journal_title

Life sciences

authors

Sheid B,Nobiletti JB,Prat JC

doi

10.1016/0024-3205(90)90336-p

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

1367-72

issue

19

eissn

0024-3205

issn

1879-0631

pii

0024-3205(90)90336-P

journal_volume

46

pub_type

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