Abstract:
:We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measured. Higher glucose concentration resulted in a greater insulin response in both capsaicin- and vehicle-treated rats. However, glucose-stimulated insulin secretion was attenuated in capsaicin-treated animals, even though glucose levels did not differ. Glucagon levels did not differ between both groups. These results show that capsaicin-sensitive nerves are involved in glucose-stimulated insulin secretion, but are not directly involved in the regulation of blood glucose levels. Moreover, they suggest that capsaicin-sensitive nerves could be involved in the regulation of insulin sensitivity. We hypothesize that sensory afferents could play a role in the aetiology of pathologies where glucohomeostatic mechanisms are disturbed, as is in type 2 diabetes mellitus.
journal_name
Life Scijournal_title
Life sciencesauthors
van de Wall EH,Gram DX,Strubbe JH,Scheurink AJ,Koolhaas JMdoi
10.1016/j.lfs.2005.03.011subject
Has Abstractpub_date
2005-07-29 00:00:00pages
1283-92issue
11eissn
0024-3205issn
1879-0631pii
S0024-3205(05)00362-0journal_volume
77pub_type
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