Expression of human alpha-fetoprotein in yeast.

abstract：:The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of ra...

journal_title：Life sciences

authors： Roberts RC,Ribak CE

更新日期：1986-09-01 00:00:00

abstract：:The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a po...

journal_title：Life sciences

authors： Ben V,Bruguerolle B

更新日期：2000-08-18 00:00:00

abstract：:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

journal_title：Life sciences

authors： Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

更新日期：1996-01-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects. MAIN METHODS:Adult male Wistar rats were exposed to ethan...

journal_title：Life sciences

authors： Mouton AJ,El Hajj EC,Ninh VK,Siggins RW,Gardner JD

更新日期：2020-03-15 00:00:00

abstract：:Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...

journal_title：Life sciences

authors： Adams A,Jarrott B

更新日期：1982-03-15 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) modulates various events through several different pathways. Many tumor cells are resistant to this cytokine. Pretreatment of these cells with actinomycin D enhances TNF-alpha-induced apoptosis. In the present study, we investigated the mechanism of this enhancement and whether ...

journal_title：Life sciences

authors： Nishida S,Yoshioka S,Kinoshita-Kimoto S,Kotani M,Tsubaki M,Fujii Y,Tomura TT,Irimajiri K

更新日期：2003-12-26 00:00:00

abstract：:In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...

journal_title：Life sciences

authors： Liu K,Zhao F,Yan J,Xia Z,Jiang D,Ma P

更新日期：2020-10-15 00:00:00

abstract：:The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growt...

journal_title：Life sciences

authors： Burch RM,Kyle DJ

更新日期：1992-01-01 00:00:00

abstract：:Significant labelled dopamine uptake was evident in bone marrow, spleen and lymph nodes of normal murine hosts in vivo. On the contrary animals bearing solid Ehrlich carcinoma, 3H-dopamine uptake was significantly reduced. The tumor tissue itself incorporated only insignificant amount of dopamine. Bone marrow cells, s...

journal_title：Life sciences

authors： Basu S,Dasgupta PS,Lahiri T,Chowdhury JR

更新日期：1993-01-01 00:00:00

abstract：:Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...

journal_title：Life sciences

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2016-08-15 00:00:00

abstract：:The binding of 3H-ouabain to human erythrocytes was analyzed in a population of hospitalized male ethanol addicted patients under long term digitalis treatment. In the non-alcoholic patient group the long term digitalis treatment induced an increase in Bmax and Kd values; such modification was not observed in the alco...

journal_title：Life sciences

authors： Battaini F,Govoni S,Mauri A,Civelli L,Trabucchi M

更新日期：1987-06-29 00:00:00

abstract：:Ischemia-reperfusion of organs such as the kidney produces reactive oxygen and free radical species in tissues and leads to injury of intracellular molecules critical to cell homeostasis. Ischemia-reperfusion affects the NADPH-dependent monooxygenase system including P450 system, which is also a source of reactive oxy...

journal_title：Life sciences

authors： Tamura Y,Imaoka S,Gemba M,Funae Y

更新日期：1997-01-01 00:00:00

abstract：:Effects of emodin (EMD) treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion (I-R) injury were examined in male and female rat hearts. Isolated-perfused hearts prepared from female rats were less susceptible to I-R injury than those of male rat...

journal_title：Life sciences

authors： Du Y,Ko KM

更新日期：2005-10-14 00:00:00

abstract：:Acetyltransferase was isolated by histone-Sepharose affinity chromatography from human cord blood red cells. The enzyme was detected only in very young red cells. The semipurified enzyme and [14C]acetyl-CoA were used to acetylate isolated Hb F tetramer and alpha and gamma subunits. The in vitro acetylated products wer...

journal_title：Life sciences

authors： Qiu CC,Kasten-Jolly J,Abraham EC

更新日期：1988-01-01 00:00:00

abstract：:SDZ PGU 693 acts as a hypoglycemic agent by stimulating glucose utilisation in insulin-sensitive peripheral tissues, such as skeletal muscle and fat. In a 28 day toxicity study the compound was found to induce hepatocellular hypertrophy in Wistar rats treated with 300 mg/kg/day. To gain insights into the pathomechanis...

journal_title：Life sciences

authors： Arce A,Aicher L,Wahl D,Anderson NL,Meheus L,Raymackers J,Cordier A,Steiner S

更新日期：1998-01-01 00:00:00

abstract：AIMS:Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism...

journal_title：Life sciences

authors： Hu,Zeng Z,Xia Q,Liu Z,Feng X,Chen J,Huang M,Chen L,Fang Z,Liu Q,Zeng H,Zhou X,Liu J

更新日期：2019-12-15 00:00:00

abstract：:Three continuous cell lines isolated from small cell carcinoma of the lung (SCCL) have been examined for their ability to take up and metabolize the biogenic amine precursors, L-DOPA and 5-hydroxytryptophane (5-HTP). In two of the three lines formaldehyde-induced fluorescence (FIF) and mass-spectrographic analysis ind...

journal_title：Life sciences

authors： Pettengill OS,Bacopoulos NG,Sorenson GD

更新日期：1982-04-19 00:00:00

abstract：:Semi-purified dog kidney Na+,K+-ATPase cross-linked with ovalbumin was used in batch-wise affinity chromatography for the detection of endogenous Na+,K+-ATPase inhibitor in human plasma and urine. Ammonium acetate 1 M washed off the endogenous inhibitor from the immobilized enzyme. The inhibitory activity of the eluat...

journal_title：Life sciences

authors： Henning G,Cloix JF,Wainer IW,Pernollet MG,Devynck MA,Meyer P

更新日期：1985-05-06 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. The iNOS and COX-2 proteins and their mRNA expressions in cultured vascul...

journal_title：Life sciences

authors： Hirafuji M,Tsunoda M,Machida T,Hamaue N,Endo T,Miyamoto A,Minami M

更新日期：2002-01-11 00:00:00

abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...

journal_title：Life sciences

authors： Fay MJ,Bush MJ,Verlangieri AJ

更新日期：1990-01-01 00:00:00

abstract：:Single unit recordings were obtained from putative dopaminergic neurons in the substantia nigra of awake, freely moving rats. The cells exhibited waveforms, range of firing rates and types of firing patterns identical to those of identified DA neurons of anesthetized or paralyzed rats. Two firing patterns were observe...

journal_title：Life sciences

authors： Freeman AS,Meltzer LT,Bunney BS

更新日期：1985-05-20 00:00:00

abstract：AIMS:Aberrant expression of miRNAs exert the critical roles in carcinogenesis, including cervical cancer. Recent study corroborated the down-regulation of miR424-5p in uterine cervix adenocarcinoma. This research aimed to investigate the function and underlying mechanisms of miR424-5p in cervical cancer cell growth. M...

journal_title：Life sciences

authors： Zhou Y,An Q,Guo RX,Qiao YH,Li LX,Zhang XY,Zhao XL

更新日期：2017-02-15 00:00:00

abstract：:Current treatment of Alzheimer's Disease (AD) requires acetylcholinesterase inhibition to increase acetylcholine (ACh) concentrations in the synaptic cleft. Another mechanism by which ACh levels can be increased is blockade of presynaptic M2 muscarinic autoreceptors that regulate ACh release. An antagonist designed fo...

journal_title：Life sciences

authors： Lachowicz JE,Duffy RA,Ruperto V,Kozlowski J,Zhou G,Clader J,Billard W,Binch H 3rd,Crosby G,Cohen-Williams M,Strader CD,Coffin V

更新日期：2001-04-27 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

journal_title：Life sciences

authors： Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

更新日期：2020-09-15 00:00:00

abstract：:We describe here a nonpeptide neuropeptide Y Y1 receptor antagonist, 2,4-dioxo-1,5-bis(2-oxo-2-orthotolyl-ethyl)-3-[3-[3-([3-[3-(3-p iperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propyl]-car bamoyloxymethyl)-phenyl]-ureido]-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diaz epine (Compound 1), which was previously synthesized as...

journal_title：Life sciences

authors： Shigeri Y,Ishikawa M,Ishihara Y,Fujimoto M

更新日期：1998-01-01 00:00:00

abstract：AIMS:Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of a combination of mitochondrial targeting nutrients on physical activity, mitochondrial function and oxidative stress in exercised ra...

journal_title：Life sciences

authors： Sun L,Shen W,Liu Z,Guan S,Liu J,Ding S

更新日期：2010-01-02 00:00:00

abstract：:Nitric oxide (NO) is generated from L-arginine by different isoforms of the enzyme nitric oxide synthase (NOS) and is known to be involved in mediating several biological functions, some of which are associated with reproduction. In this study, we examined the ability of the prepubertal ovary to express the inducible ...

journal_title：Life sciences

authors： Srivastava V,Jones BJ,Dookwah H,Hiney JK,Dees WL

更新日期：1997-01-01 00:00:00

abstract：:Metalloproteinases (MMP), particularly MMP-9 produced by the intratumor monocyte/macrophages, play an important role in tumor invasion and metastases. Recent clinical trials in patients with primary breast cancer suggest that bisphosphonates (BP), above all clodronate, may reduce bone metastases. The aim of the presen...

journal_title：Life sciences

authors： Valleala H,Hanemaaijer R,Mandelin J,Salminen A,Teronen O,Mönkkönen J,Konttinen YT

更新日期：2003-09-26 00:00:00

abstract：AIMS:Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. We...

journal_title：Life sciences

authors： Rocha-Rodrigues S,Santos-Alves E,Coxito PM,Marques-Aleixo I,Passos E,Guimarães JT,Martins MJ,Oliveira PJ,Magalhães J,Ascensão A

更新日期：2013-09-03 00:00:00

abstract：AIMS:Lipid soluble vitamin E plays a role in several physiological mechanisms, however, the mechanism of this action is controversial. We investigated how tocopherol (α-tocopherol acid succinate) influences the effects of cyclooxygenase inhibitors (COXi) in the smooth muscles. MAIN METHODS:The contractility of the sam...

journal_title：Life sciences

authors： Kothencz A,Hajagos-Tóth J,Csányi A,Gáspár R

更新日期：2018-01-01 00:00:00