Biogenic amine metabolites in human lung tumor cells: histochemical and mass-spectrographic demonstration.

abstract：AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN ...

journal_title：Life sciences

authors： Msoka TF,Van Guilder GP,van Furth M,Smulders Y,Meek SJ,Bartlett JA,Vissoci JRN,van Agtmael MA

更新日期：2019-10-15 00:00:00

abstract：:Recently, single-dose drug packaging systems, allowing the administration of multiple drugs in a single pill, have become popular for the convenience of the patient. The quality of drugs and an accurate measurement of their photostabilities within this system, however, have not been carefully addressed. Drugs that are...

journal_title：Life sciences

authors： Uwai K,Tani M,Ohtake Y,Abe S,Maruko A,Chiba T,Hamaya Y,Ohkubo Y,Takeshita M

更新日期：2005-12-12 00:00:00

abstract：:Behavioral study of pro-opiomelanocortin products indicates that beta-endorphin and corticotrophin-like peptides have antagonistic effects. However, these peptides have similar actions on the rat vas deferens. beta-endorphin, alpha-MSH and ACTH each inhibit electrically evoked contraction of the duct, but the corticot...

journal_title：Life sciences

authors： Smock T

更新日期：1986-11-03 00:00:00

abstract：:The in vivo effect of trazodone on the density of [(3)H]5-HT binding sites and 5-HT(1A) receptors and adenylyl cyclase (AC) response was studied in regions of rat brain. The chronic administration of trazodone (10 mg/Kg body wt, 40 days) resulted in a significant downregulation of [(3)H]5-HT binding sites and 5-HT(1A)...

journal_title：Life sciences

authors： Subhash MN,Srinivas BN,Vinod KY

更新日期：2002-08-16 00:00:00

abstract：:The specific binding of 35S-t-butylbicyclophosphorothionate (TBPS) was studied in synaptosomal membranes of rat cerebral cortex. The displacing potencies of eleven CNS depressants and three convulsants were determined in the presence of 1 microM GABA and 10 nM R 5135. GABA enhanced the displacing potencies of depressa...

journal_title：Life sciences

authors： Maksay G,Ticku MK

更新日期：1988-01-01 00:00:00

abstract：AIMS:This study evaluated the role of cyclophilin A (CyPA) in early phase of atherosclerosis and also examined the atheroprotective effects of melatonin due to its antioxidant properties. MAIN METHODS:APOE null mice at 6 and 15weeks of age were treated with melatonin at a dose of 0.1mg/kg/day or 10mg/kg/day. We evalua...

journal_title：Life sciences

authors： Rezzani R,Favero G,Stacchiotti A,Rodella LF

更新日期：2013-05-20 00:00:00

abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...

journal_title：Life sciences

authors： Tong G,Sun Z,Wei X,Gu C,Kaye AD,Wang Y,Li J,Zhang Q,Guo H,Yu S,Yi D,Pei J

更新日期：2011-01-03 00:00:00

abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

journal_title：Life sciences

authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

更新日期：2004-12-17 00:00:00

abstract：:Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-NG-nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reve...

journal_title：Life sciences

authors： Morley JE,Flood JF

更新日期：1991-01-01 00:00:00

abstract：AIMS:A bridging ligand 2,4,6-pyridine tricarboxylic acid (H(3)ptc) and its manganese(II) complex [Mn(Hptc)(phen)(OH)]n(Hptc=2,4,6-pyridine tricarboxylic acid, phen=1,10-phenanthroline) have been synthesized and characterized. MAIN METHODS:The interaction with DNA (HeLa and KB) was carried out by fluorescence spectrum ...

journal_title：Life sciences

authors： Zhu M,He W,Gao E,Lin L,Zhang Y,Dai L,Wang R,Wang B,Wang M

更新日期：2012-04-09 00:00:00

abstract：:Diltiazem, diazepam, and clonazepam effectively inhibit Na+-induced Ca2+ release from mitochondria isolated from rabbit heart and rat brain. At 10 mM NaCl, the 50% inhibition of the rate of Ca2+ release occurred at 5, 7, 40 and 350 microM of clonazepam d-cis-diltiazem, diazepam and 1-cis-diltiazem, respectively. Ro 15...

journal_title：Life sciences

authors： Matlib MA,Schwartz A

更新日期：1983-06-20 00:00:00

abstract：AIMS:The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model. MAIN METHODS:Rats were randomized to normothermia (n = 10) or ...

journal_title：Life sciences

authors： Shi J,Dai W,Carreno J,Hale SL,Kloner RA,Kay GL

更新日期：2019-07-15 00:00:00

abstract：AIMS:Colorectal cancer (CRC) is one of the most common cancers with poor prognosis worldwide. The advent of immunotherapy has greatly improved survival in refractory patients of CRC. In this study, we aimed to identify reliable immune classification and biomarkers that predict immunotherapeutic responses in CRC patient...

journal_title：Life sciences

authors： Li M,Li W,Yang X,Wang H,Peng Y,Yin J,Lu Y,Liu L,Shang J,Zhao Q

更新日期：2020-11-15 00:00:00

abstract：:Several serotonin (5-HT) receptor antagonists with varying specificities for the 5-HT receptor types, were studied with regard to their effects on blood glucose levels in mice. The non-selective antagonists, metergoline and methysergide, proved to be hyperglycemic at doses commonly used to antagonize 5-HT receptors. I...

journal_title：Life sciences

authors： Wozniak KM,Linnoila M

更新日期：1991-01-01 00:00:00

abstract：AIMS:Cold stress has been shown to produce dramatic increases in 2-fluoro-2-deoxy-D-Glucose ((18)FDG) accumulation by brown adipose tissue (BAT) in rodents. However, neither the effects of other types of stress on (18)FDG accumulation nor the effects of stressors on the accumulation of tracers of other aspects of energ...

journal_title：Life sciences

authors： Carter EA,Bonab AA,Hamrahi V,Pitman J,Winter D,Macintosh LJ,Cyr EM,Paul K,Yerxa J,Jung W,Tompkins RG,Fischman AJ

更新日期：2011-07-18 00:00:00

abstract：:The Ca2+ ionophore A23187 (0.2-5 microM) stimulates the phosphorylation of the substrates of protein kinase C (40,000 dalton protein) and myosin light chain kinase (20,000 dalton protein) in the presence or absence of cyclooxygenase inhibitors. In the presence of cyclooxygenase inhibitors or millimolar Ca2+ there is n...

journal_title：Life sciences

authors： Lapetina EG,Reep B,Watson SP

更新日期：1986-08-25 00:00:00

abstract：:Elevated levels of serum free fatty acids (FFA) may be the metabolic alteration in obesity that leads to insulin resistance (IR) and type 2 diabetes mellitus (DM). The obese Zucker rat (ZR) is a genetic model of juvenile-onset obesity and type 2 DM. Compared with its lean sibling, the obese ZR is hyperinsulinemic, hyp...

journal_title：Life sciences

authors： Abadie JM,Malcom GT,Porter JR,Svec F

更新日期：2001-10-19 00:00:00

abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...

journal_title：Life sciences

authors： Graham D,Langer SZ

更新日期：1992-01-01 00:00:00

abstract：:We investigated whether calcium channel antagonists would alter the induction of nitric oxide (NO) synthesis by bacterial lipopolysaccharide (LPS) alone or in combination with interferon-gamma (IFN gamma) in cultured J774 macrophages, rat vascular smooth muscle cells, rat renal mesangial cells, and rat cardiac myocyte...

journal_title：Life sciences

authors： Hattori Y,Kasai K,So S,Hattori S,Banba N,Shimoda S

更新日期：1995-01-01 00:00:00

abstract：:[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorp...

journal_title：Life sciences

authors： Young E,Walker JM,Houghten R,Akil H

更新日期：1983-01-01 00:00:00

abstract：AIMS:The prognoses of patients with gastric cancer(GC) vary in different stages, which is mainly due to the great differences in tumor and tumor microenvironment. This study is aimed to explore the specific differences. MAIN METHODS:Based on RNAseq-based expression data from The Cancer Genome Atlas database and GSE154...

journal_title：Life sciences

authors： Wan L,Tan N,Zhang N,Xie X

更新日期：2020-11-15 00:00:00

abstract：:The recently discovered highly specific delta opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP) was radiolabelled by catalytic tritiation of its precursor [Tyr (3', 5'-I2)1]TIPP. The tritiated ligand labelled rat brain membrane binding sites with a Kd value of 0.64 nM and a Bmax of 82 fmol/mg protein. Binding competition ...

journal_title：Life sciences

authors： Nevin ST,Toth G,Nguyen TM,Schiller PW,Borsodi A

更新日期：1993-01-01 00:00:00

abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

journal_title：Life sciences

authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

更新日期：2021-02-01 00:00:00

abstract：AIMS:Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in melanoma. MATERIALS AND METHODS:Expression of circ_00840...

journal_title：Life sciences

authors： Chen Z,Chen J,Wa Q,He M,Wang X,Zhou J,Cen Y

更新日期：2020-02-15 00:00:00

abstract：:The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system. Human neutrophilic polymorphon...

journal_title：Life sciences

authors： Yoshida N,Yoshikawa T,Nakamura Y,Takenaka S,Sakamoto K,Manabe H,Nakagawa S,Kondo M

更新日期：1997-01-01 00:00:00

abstract：:Pretreatment with a low dose of 3-nitropropionic acid (3-NPA) has been shown to induce ischemic tolerance in the gerbil hippocampus. It is well known that sublethal (2-min) ischemia also induces ischemic tolerance. To investigate the acquisition of ischemic tolerance with 3-NPA, we examined the protein expression afte...

journal_title：Life sciences

authors： Kato K,Shimazaki K,Kamiya T,Amemiya S,Inaba T,Oguro K,Katayama Y

更新日期：2005-10-21 00:00:00

abstract：:This experiment was designed to assess the role of the septo-hippocampal cholinergic (ACh) system in the deleterious effects produced by systemic benzodiazepine injection on learning processes in rats. Retention of a step through passive avoidance task was analysed after systemic injection of increasing doses of eithe...

journal_title：Life sciences

authors： Anglade F,Chapouthier G,Galey D

更新日期：1999-01-01 00:00:00

abstract：:The ontogeny and regulation by isoproterenol of type II thyroxine 5'-deiodinase, N-acetyltransferase, and hydroxyindole-O-methyltransferase activities were studied in the rat Harderian gland. Both 5'-deiodinase and N-acetyltransferase activities exhibited maximal values at the first week of age. These activities gradu...

journal_title：Life sciences

authors： Osuna C,Rubio A,Goberna R,Guerrero JM

更新日期：1990-01-01 00:00:00

abstract：:Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was a...

journal_title：Life sciences

authors： Carrillo MC,Kanai S,Nokubo M,Kitani K

更新日期：1991-01-01 00:00:00

abstract：:Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...

journal_title：Life sciences

authors： Fariello RG,Ferraro TN,Golden GT,DeMattei M

更新日期：1988-01-01 00:00:00