Abstract：
:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes in adriamycin induced cardiomyopathy was investigated in rats. The rats administered with adriamycin (2.5 mg/kg body wt, i.p) caused myocardial damage that was manifested by the elevation of serum marker (LDH, CPK, GOT and GPT) enzymes and showed significant changes in the antioxidant enzymes (SOD, CAT, GPx, GST). Pre-co-treatment with Centella asiatica(200 mg/kg of body wt/oral) extract significantly prevented these alterations and restored the enzyme activities to near normal levels. These findings demonstrate the cardio protective effect of Centella asiatica on antioxidant tissue defense system during adriamycin induced cardiac damage in rats.
journal_name
Life Scijournal_title
Life sciencesauthors
Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki Tdoi
10.1016/j.lfs.2004.09.009subject
Has Abstractpub_date
2004-12-17 00:00:00pages
585-97issue
5eissn
0024-3205issn
1879-0631pii
S0024-3205(04)00838-0journal_volume
76pub_type
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