Inhibition of peristaltic activity by cannabinoids in the isolated distal colon of mouse.

abstract：AIMS:A growing body of evidence shows the cardiovascular benefits of fish oil ingredients, including eicosapentaenoic acid (EPA), in humans and experimental animals. However, the effects of EPA on endothelin (ET)-1-induced cardiomyocyte hypertrophy and the involved signaling cascade are largely unknown. A previous stud...

journal_title：Life sciences

authors： Shimojo N,Jesmin S,Sakai S,Maeda S,Miyauchi T,Mizutani T,Aonuma K,Kawano S

更新日期：2014-11-24 00:00:00

abstract：:The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compou...

journal_title：Life sciences

authors： Raj P,Louis XL,Thandapilly SJ,Movahed A,Zieroth S,Netticadan T

更新日期：2014-01-30 00:00:00

abstract：AIM:This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats. MAIN METHODS:The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12weeks. Th...

journal_title：Life sciences

authors： Tian YF,Hsia TL,Hsieh CH,Huang DW,Chen CH,Hsieh PS

更新日期：2011-07-18 00:00:00

abstract：:Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge about the multifaceted role of nitric oxide in a variety of disease states has led to the design of multiple treatment strategies involving the nitric oxide sy...

journal_title：Life sciences

authors： Grant MK,El-Fakahany EE

更新日期：2004-02-20 00:00:00

abstract：:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with ...

journal_title：Life sciences

authors： Fang M,Li J,Rudd JA,Wai SM,Yew JC,Yew DT

更新日期：2006-02-09 00:00:00

abstract：:Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and neuroprotective effects. The present study aims to investigate the antidepressant effe...

journal_title：Life sciences

authors： Jiang N,Lv J,Wang H,Huang H,Wang Q,Lu C,Zeng G,Liu XM

更新日期：2020-07-01 00:00:00

abstract：:Elevated total homocysteine concentrations and obesity are both associated with an increased risk of cardiovascular disease. However, previous studies of weight reduction on serum homocysteine concentrations have obtained inconsistent reports. We investigated the effect of folic acid supplementation on serum homocyste...

journal_title：Life sciences

authors： Sheu WH,Chin HM,Lee WJ,Wan CJ,Su HY,Lang HF

更新日期：2005-03-18 00:00:00

abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...

journal_title：Life sciences

authors： Graham D,Langer SZ

更新日期：1992-01-01 00:00:00

abstract：AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...

journal_title：Life sciences

authors： Novaes RD,Gonçalves RV,Penitente AR,Bozi LH,Neves CA,Maldonado IR,Natali AJ,Talvani A

更新日期：2016-05-01 00:00:00

abstract：:Interactions of the synthetic pyrethroid allethrin with the nicotinic acetylcholine (ACh) receptor/channel were studied in membranes from Torpedo electric organ. Allethrin did not inhibit binding of [3H]ACh to the receptor sites, but inhibited noncompetitively binding of [3H]perhydrohistrionicotoxin ([3H]H12-HTX) to t...

journal_title：Life sciences

authors： Abbassy MA,Eldefrawi ME,Eldefrawi AT

更新日期：1982-10-11 00:00:00

abstract：:In order to investigate the action of ethanol on the anterior pituitary gland, the effect of ethanol on prolactin secretion in vitro was studied. Ethanol significantly increased the in vitro incorporation of 3H-leucine into both prolactin contained within the pituitary gland and that released into the medium. The enha...

journal_title：Life sciences

authors： Seilicovich A,Duvilanski BH,Debeljuk L,Díaz MC,Muñoz Maines V,Rettori V

更新日期：1984-11-05 00:00:00

abstract：:Treatment of primary cultured chondrocytes from rabbit articular cartilage with interleukin-1 (IL-1)alpha and plasminogen induced the production of pro-matrix metalloproteinase 1 (proMMP-1/interstitial collagenase), proMMP-3 (stromelysin 1) and proMMP-9 (gelatinase B), as well as their active forms. Human urinary tryp...

journal_title：Life sciences

authors： Hashimoto K,Nagao Y,Kato K,Mori Y,Ito A

更新日期：1998-01-01 00:00:00

abstract：:The binding of norepinephrine (NE) to plasma proteins of fresh human blood obtained from healthy volunteers was studied by ultrafiltration at different NE concentrations and incubation times at 37 degrees C. At 1.7 nM L-[3H]-NE binding was approximately 25%. The binding was rapid and was not influenced by the incubati...

journal_title：Life sciences

authors： de Vera N,Cristófol RM,Rodríguez Farré E

更新日期：1988-01-01 00:00:00

abstract：AIMS:The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. MATERIALS AND METHODS:circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression...

journal_title：Life sciences

authors： Zou J,Liu KC,Wang WP,Xu Y

更新日期：2020-09-01 00:00:00

abstract：:S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....

journal_title：Life sciences

authors： Chabannes B,Sarda N,Cronenberger L,Pacheco H

更新日期：1984-08-06 00:00:00

abstract：:Despite the lack of knowledge of the effects of electronic cigarettes (e-cigarettes, e-cigs) on public health, they have been proposed as a part of smoking cessation efforts. Recently, several basic scientific studies have pointed out how e-cigs can generate carcinogens, such as e-cig liquid thermal degradation by-pro...

journal_title：Life sciences

authors： Vivarelli F,Canistro D,Cirillo S,Cardenia V,Rodriguez-Estrada MT,Paolini M

更新日期：2019-07-01 00:00:00

abstract：:Adenylate cyclase activity in pancreatic acinar cell membranes was determined in rats that had undergone a treatment with pentagastrin (250 micrograms/kg, intraperitoneal three times daily) for 1 week or that had undergone small bowel resection (90%) and were sacrified at 2 weeks, 1 month and 6 months after interventi...

journal_title：Life sciences

authors： Alvaro-Alonso I,Boyano-Adánez MC,Martín-Espinosa A,Arilla E

更新日期：1995-01-01 00:00:00

abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

journal_title：Life sciences

authors： Maccarrone C,Jarrott B

更新日期：1988-01-01 00:00:00

abstract：:Acetylcholine (ACh) may be an ovarian signaling molecule, since ACh is produced by non-neuronal granulosa cells (GCs) derived from the antral follicle, and likely also by their in vivo counterparts in the growing follicle. Furthermore, muscarinic ACh receptors (MR) are present in GC membranes and in cultured human GCs...

journal_title：Life sciences

authors： Kunz L,Roggors C,Mayerhofer A

更新日期：2007-05-30 00:00:00

abstract：:[3H]5-HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus (CN). [3H]5-HT labeled both 5-HT1A and 5-HT1C recognition sites, defined by nanomolar affinity for 8-OH-DPAT and mesulergine respectively; however, these represented only a fraction of total specific [3H]5-HT binding. Saturation...

journal_title：Life sciences

authors： Xiong WC,Nelson DL

更新日期：1989-01-01 00:00:00

abstract：:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...

journal_title：Life sciences

authors： Bhattacharya D,Majrashi M,Ramesh S,Govindarajulu M,Bloemer J,Fujihashi A,Crump BR,Hightower H,Bhattacharya S,Moore T,Suppiramaniam V,Dhanasekaran M

更新日期：2018-02-01 00:00:00

abstract：:The effects of methyl vitamin B12 (5-6 mg/kg, p.o.) on the entrainment of circadian running wheel activity rhythm to a new lighting schedule were measured in rats. After the light-dark (LD) cycle was abruptly reversed, rats given vitamin B12 took less time to entrain their circadian locomotor activity rhythm to the ne...

journal_title：Life sciences

authors： Tsujimaru S,Ida Y,Satoh H,Egami H,Shirao I,Mukasa H,Nakazawa Y

更新日期：1992-01-01 00:00:00

abstract：:A radioreceptor assay using [3H]nitrendipine and rat cerebral cortical membranes, in conjunction with equilibrium dialysis, measures the unbound (free) level of nitrendipine in human sera. The sensitivity of the assay is 0.1-0.2 picomoles/ml and is linear from 4 X 10(-11) to 4 X 10(-9) M nitrendipine. Other dihydropyr...

journal_title：Life sciences

authors： Lee HR,Roeske WR,Yamamura HI

更新日期：1983-10-31 00:00:00

abstract：:Ketamine, used clinically as an intravenous analgetic and dissociative anaesthetic agent, is a racemate with both pharmacokinetic and pharmacodynamic enantioselectivity. S-ketamine has been found have a higher clearance and greater potency than R-ketamine as well as a greater therapeutic index. We performed a study in...

journal_title：Life sciences

authors： Edwards SR,Mather LE

更新日期：2001-09-14 00:00:00

abstract：:There is an augmented platelet intracellular calcium response to serotonin stimulation in major depression. The role that calcium influx has in this process is not known. The objective of this study was to determine platelet calcium influx in response to serotonin by two methods, Mn2+ influx and 45Ca2+ uptake, in orde...

journal_title：Life sciences

authors： Plein H,Berk M,Eppel S,Butkow N

更新日期：2000-01-01 00:00:00

abstract：AIMS:This study evaluated the role of cyclophilin A (CyPA) in early phase of atherosclerosis and also examined the atheroprotective effects of melatonin due to its antioxidant properties. MAIN METHODS:APOE null mice at 6 and 15weeks of age were treated with melatonin at a dose of 0.1mg/kg/day or 10mg/kg/day. We evalua...

journal_title：Life sciences

authors： Rezzani R,Favero G,Stacchiotti A,Rodella LF

更新日期：2013-05-20 00:00:00

abstract：AIMS:High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in diabetic animals and in myotubes in vitro. However, whether puerarin can act...

journal_title：Life sciences

authors： Chen X,Yi L,Song S,Wang L,Liang Q,Wang Y,Wu Y,Gao Q

更新日期：2018-08-01 00:00:00

abstract：:In the present study we compared, in vivo in rats, the hepatobiliary transport of monovalent (silver:Ag) and divalent metals (zinc:Zn; cadmium:Cd) with that of copper (Cu). Cu can have two oxidation states in vivo, i.e. Cu(I) and Cu(II). Studies were performed in normal Wistar (NW) rats and mutant GY Wistar rats. The ...

journal_title：Life sciences

authors： Dijkstra M,Havinga R,Vonk RJ,Kuipers F

更新日期：1996-01-01 00:00:00

abstract：:Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME), deteriorate insulin sensitivity and lipid metabolism, while the addition of L-arginine reverses this deterioration. L-arginine is a precurso...

journal_title：Life sciences

authors： Kawano T,Nomura M,Nisikado A,Nakaya Y,Ito S

更新日期：2003-10-24 00:00:00

abstract：:Infusion of oxytocin (OT) into normal dogs, in doses which produced plasma levels of OT in the physiological range, has been shown to increase plasma levels of glucose, insulin and glucagon and increase rates of glucose production and uptake. This study sought to determine whether there was a correlation between these...

journal_title：Life sciences

authors： Altszuler N,Rosenberg CR,Winkler B,Fuchs AR,Hill PS,Hruby VJ

更新日期：1992-01-01 00:00:00