Human urinary trypsin inhibitor inhibits the activation of pro-matrix metalloproteinases and proteoglycans release in rabbit articular cartilage.

abstract：:The mechanism of spontaneous coronary contractions was investigated in the rabbit. Arteries with intact endothelium did not spontaneously contract. However, spontaneous coronary contractions were generated after the removal of the endothelium. NG-nitro-L-arginine methyl ester and methylene blue, the inhibitors of the ...

journal_title：Life sciences

authors： Omote M,Mizusawa H

更新日期：1994-01-01 00:00:00

abstract：AIMS:We recently reported that acute exposure to nicotine vasodilates the renal vasculature of male rats via facilitation of endothelial nitric oxide synthase (eNOS). In this study, we investigated whether this effect of nicotine is sexually dimorphic and the role of estrogen in modulating the nicotine effect. MAIN ME...

journal_title：Life sciences

authors： el-Mas MM,el-Gowilly SM,Gohar EY,Ghazal AR,Abdel-Rahman AA

更新日期：2011-01-17 00:00:00

abstract：:An in vitro preparation of rabbit thoracic aorta was tested in order to determine whether isometric contractile force induced by endothelin-1 (ET-1) in this preparation is changed when the tissue is exposed to ultraviolet (UV) light. After constriction of an aortic segment to a steady-state level of tension with ET-1,...

journal_title：Life sciences

authors： Nordberg LO,Raffa RB,Tallarida RJ

更新日期：1993-01-01 00:00:00

abstract：:Concanavalin A enhanced the rat rectal absorption of phenol red and cefoxitin at pH 7.4 and the uptake of cefoxitin into brush border membrane vesicles prepared from rat rectal membrane. The enhancing action of concanavalin A demonstrated a sodium ion dependency and was inhibited by the presence of 4,4'-diisothiocyano...

journal_title：Life sciences

authors： Nishihata T,Higuchi T

更新日期：1984-01-30 00:00:00

abstract：:The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred wit...

journal_title：Life sciences

authors： Pickworth WB,Bunker E,Welch P,Cone E

更新日期：1991-01-01 00:00:00

abstract：:Pregnant mice are more susceptible to flurothyl-induced seizures than are non-pregnant controls. The possibility that the well-known increase in beta-endorphin concentration which accompanies pregnancy was involved in this effect was examined by testing whether naloxone administration could block the increased seizure...

journal_title：Life sciences

authors： Smolen A,Smolen TN,van de Kamp JL

更新日期：1986-05-26 00:00:00

abstract：:The effects of the cannabinoid receptor agonist Win 55,212-2 and of the competitive cannabinoid receptor antagonist SR 141716A on the electrically-evoked peristalsis of isolated distal colon of mouse were studied. Intraluminal pressure, longitudinal displacement, ejected fluid volume and changes in morphology of exter...

journal_title：Life sciences

authors： Mancinelli R,Fabrizi A,Del Monaco S,Azzena GB,Vargiu R,Colombo GC,Gessa GL

更新日期：2001-05-25 00:00:00

abstract：:The present study examined the discriminative stimulus and response rate-decreasing effects of kappa opioids in pigeons trained to discriminate a 0.017 mg/kg dose of bremazocine from saline. Bremazocine, spiradoline, CI977, U69,593 and U50,488 substituted completely for the bremazocine stimulus in a dose-dependent and...

journal_title：Life sciences

authors： Picker MJ

更新日期：1994-01-01 00:00:00

abstract：:The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor id...

journal_title：Life sciences

authors： Lötsch J,Darimont J,Skarke C,Zimmermann M,Hummel T,Geisslinger G

更新日期：2001-09-28 00:00:00

abstract：:Virgin, male Sprague-Dawley rats were used to study the production of cardiac failure by a single subcutaneous injection of 85 mg/kg dl-isoproterenol (ISO) and the possible preservation of cardiac function by a pre-treatment of 50 mg/kg verapamil (VER) 5 min prior to 85 mg/kg ISO. At 24 hrs after drug injections cardi...

journal_title：Life sciences

authors： Yeager JC,Whitehurst ME

更新日期：1982-01-18 00:00:00

abstract：:We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...

journal_title：Life sciences

authors： Bousquet P,Feldman J

更新日期：1987-03-16 00:00:00

abstract：:Psychostimulants including amphetamine and cocaine induce locomotion and stereotypy and suppress eating. Although the capacity of cocaine to alter locomotion is usually viewed as related to dopamine neurotransmission, recent studies suggest that norepinephrine, acting through alpha1-adrenergic receptors (alpha1-ARs) c...

journal_title：Life sciences

authors： Clifford PS,Davis KW,Elliott AE,Wellman PJ

更新日期：2007-09-08 00:00:00

abstract：:Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...

journal_title：Life sciences

authors： Calil CM,Marcondes FK

更新日期：2006-07-10 00:00:00

abstract：:The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and CGS 8216, a pyrazoloquinoline, was assessed in two different regions of the rat brain. PK 8165, a compound with reported anxiolytic properties, inhibited [3H]-propyl beta-carboline-3-carboxylate labeled receptors in the...

journal_title：Life sciences

authors： Morelli M,Gee KW,Yamamura HI

更新日期：1982-07-05 00:00:00

abstract：:The role of K+ channels in the relaxations induced by bradykinin, lemakalim, an activator of ATP-sensitive K+ channels and sodium nitroprusside (SNP), a nitric oxide (NO) donor was examined in the isolated mouse trachea precontracted by methacholine (1 microM). 4-aminopyridine (4-AP, 0.1-2 mM), an inhibitor of 4-AP se...

journal_title：Life sciences

authors： Li L,Vaali K,Paakkari I,Vapaatalo H

更新日期：1997-01-01 00:00:00

abstract：:To clarify the mechanism by which Delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, impairs spatial memory in the 8-arm radial maze in rats via the cholinergic system, we used two acetylcholinesterase inhibitors, physostigmine and tetrahydroaminoacridine. Moreover, we examined the effect of Del...

journal_title：Life sciences

authors： Mishima K,Egashira N,Matsumoto Y,Iwasaki K,Fujiwara M

更新日期：2002-12-20 00:00:00

abstract：:In our previous paper (Biochem. Biophys. Res. Commun. 141, 20-26 (1986) we reported the isolation of a 34000-dalton protein (p34K) which binds to calmodulin and F-actin from chicken gizzard smooth muscle. We examined the distribution of the immunoreactive component of gizzard p34K in bovine tissues by immunoblot analy...

journal_title：Life sciences

authors： Takahashi K,Hiwada K,Kokubu T

更新日期：1987-07-20 00:00:00

abstract：:Male Sprague-Dawley rats were given a single electroconvulsive shock (ECS) on alternate days and sacrificed 48 hrs after 1, 3, or 5 seizures. The content of TRH in hippocampus, pyriform cortex and amygdala was increased 2.5-fold, 5.4-fold and 4.3-fold respectively, 48 hrs. after 3 alternate-day electroconvulsive shock...

journal_title：Life sciences

authors： Kubek MJ,Meyerhoff JL,Hill TG,Norton JA,Sattin A

更新日期：1985-01-28 00:00:00

abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

journal_title：Life sciences

authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

更新日期：2020-06-15 00:00:00

abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...

journal_title：Life sciences

authors： Lv H,Yue J,Chen Z,Chai S,Cao X,Zhan J,Ji Z,Zhang H,Dong R,Lai K

更新日期：2016-04-15 00:00:00

abstract：:Dopamine (DA), one of the major sources of reactive oxygen species (ROS), is implicated in neuronal death associated with Parkinson's disease (PD). Preconditioning with oxidative stress has been shown to provide cytoprotection similar to ischemic preconditioning (IPC), against cell apoptosis. In this study, using the ...

journal_title：Life sciences

authors： Xiao-Qing T,Jun-Li Z,Yu C,Jian-Qiang F,Pei-Xi C

更新日期：2005-11-19 00:00:00

abstract：:Flavonoids from the leaves of Diospyros kaki L (FLDK-P70) are main therapeutic components of NaoXingQing, which is a novel and patented Traditional Chinese Medicine drug used for the treatment of syndrome of apoplexy for years in China. The present study investigated the effects of FLDK-P70 on hydrogen peroxide (H2O2)...

journal_title：Life sciences

authors： Bei W,Peng W,Ma Y,Xu A

更新日期：2005-03-11 00:00:00

abstract：:A completely randomized controlled study based on a rabbit model was designed to study the effect of repetitive ischemic preconditioning (IPC) on a spinal cord ischemic reperfusion injury. Twenty four white adult Japanese rabbits were randomly assigned to one of the 3 groups (n = 8 per group): Group I: sham-operation ...

journal_title：Life sciences

authors： Yu QJ,Wang YL,Zhou QS,Huang HB,Tian SF,Duan DM

更新日期：2006-09-05 00:00:00

abstract：:Pretreatment of pancreatic acini with 5-hydroxytryptamine (5-HT) reduced the binding of the labeled somatostatin (SS) analogue 125I-Tyr3-SMS to pancreatic acinar membranes. This effect was dependent of the dose of 5-HT used and length of pretreatment. This inhibitory effect of 5-HT was abolished when pancreatic acini ...

journal_title：Life sciences

authors： Muñoz-Acedo G,Rodríguez-Martin E,Puebla L,Arilla E

更新日期：1997-01-01 00:00:00

abstract：:The thyrotropin receptor is proposed to contain both a glycoprotein and a ganglioside component. Monoclonal antibodies have been developed against soluble thyroid TSH receptor preparations and using Graves' lymphocytes. These show that initial recognition of thyrotropin requires the glycoprotein component, but that mo...

journal_title：Life sciences

authors： Kohn LD,Valente WA,Laccetti P,Cohen JL,Aloj SM,Grollman EF

更新日期：1983-01-03 00:00:00

abstract：:We studied the effects of caffeine on intracellular calcium in a clonal insulin-secreting cell line RINm5F. Caffeine (1-30 mM) induced a dose-dependent intracellular Ca2+ release and Ca2+ influx. Pretreatment with combination of ryanodine (10 microM) and caffeine (10 mM), but not ryanodine alone, abolished subsequent ...

journal_title：Life sciences

authors： Chen TH,Lee B,Yang C,Hsu WH

更新日期：1996-01-01 00:00:00

abstract：:In the present report, the putative effect of a single electrical stimulation (75, 150 or 300 microA) to the baso-lateral amygdala (BLA) nucleus was assessed in shock probe defensive burying behavior test (DB) and elevated plus maze (EPM). These models have been used for measuring anxiety levels and screening putative...

journal_title：Life sciences

authors： Saldívar-González JA,Posadas-Andrews A,Rodríguez R,Gómez C,Hernández-Manjarrez ME,Ortiz-León S,Martínez-Pineda A,Gómez-Laguna D,Salgado V,Manjarrez J,Alvarado R

更新日期：2003-01-03 00:00:00

abstract：:Skeletal muscle viability is crucially dependent on the tissue levels of its high energy phosphates. In this study we investigated the effect of the preservation medium Perfadex and illumination with Singlet Oxygen Energy (SOE). Singlet oxygen can be produced photochemically by energy transfer from an excited photosen...

journal_title：Life sciences

authors： Lindgård A,Lundberg J,Rakotonirainy O,Elander A,Soussi B

更新日期：2003-04-25 00:00:00

abstract：:The concentrations and molecular forms of urinary and plasma gastrin from normal subjects were studied by radioimmunoassays using two region-specific antisera. Urinary concentration of NH2-terminal big gastrin (G-34) immunoreactivity was several hundred times as great as that of COOH-terminal gastrin immunoreactivity....

journal_title：Life sciences

authors： Higashimoto Y,Himeno S,Shinomura Y,Kanayama S,Nagao K,Tarui S

更新日期：1990-01-01 00:00:00

abstract：AIMS:Morus, a member of the family Moraceae and commonly known as the mulberry, comprises a pharmaceutically important plant group whose major constituents are the moracins. Moracin derivatives have received great attention because they exhibit a diverse range of biological functionalities. However, no studies have con...

journal_title：Life sciences

authors： Seong SH,Ha MT,Min BS,Jung HA,Choi JS

更新日期：2018-10-01 00:00:00