Abstract：
:Pregnant mice are more susceptible to flurothyl-induced seizures than are non-pregnant controls. The possibility that the well-known increase in beta-endorphin concentration which accompanies pregnancy was involved in this effect was examined by testing whether naloxone administration could block the increased seizure susceptibility. Pregnant female, control female and male C3H mice were treated with 5-50 mg/kg naloxone 5 min before flurothyl seizure testing. Naloxone markedly increased clonic seizure susceptibility in all three groups at a dose of 50 mg/kg, but had little effect at lower doses. In contrast, naloxone had differential effects on myoclonic seizures in pregnant and control female mice, being anticonvulsant in the controls, but proconvulsant in the pregnant mice. A role for endogenous opiates is unlikely in mediating clonic seizures in pregnant mice, but may be involved in myoclonic seizures.
journal_name
Life Scijournal_title
Life sciencesauthors
Smolen A,Smolen TN,van de Kamp JLdoi
10.1016/0024-3205(86)90218-3subject
Has Abstractpub_date
1986-05-26 00:00:00pages
1899-905issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(86)90218-3journal_volume
38pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：AIMS:Osteoblasts and adipocytes originate from common precursor cells. We examined the effects of bone morphogenetic protein-2 (BMP-2) on the molecular mechanisms governing the diametric actions of BMP-2 on simultaneous mature osteoblast and adipocyte differentiation in a clonal mesenchymal progenitor cell line, ROB-C2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.12.011
更新日期：2009-02-27 00:00:00
abstract：:L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90580-5
更新日期：1983-01-01 00:00:00
abstract：:Although the aging effect of dopamine D2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D2 receptor has not been fully examined. Since the density of extrastriatal dopamine D2 receptor is very low, suitable ligands are limited. In this study, we used [11C]FLB 457 to quanti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01205-x
更新日期：2001-07-20 00:00:00
abstract：:Groups of 35-day-old male C57BL/6 mice were stressed 1 hour per day by immobilization for 1, 2, 3, 5, 8, 11 or 14 consecutive days. Control groups were left undisturbed. The animals were then killed and body weight and the weights of the thymus, spleen and axillary lymph nodes determined. Chronic immobilization stress...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00606-1
更新日期：1997-01-01 00:00:00
abstract：:Aging exerts profound influences on the function of the hypothalamic-pituitary-testicular-axis. This work has been performed in order to verify whether, in male rats, the decreased secretion of LH and testosterone (T) occurring in old animals is reflected by modifications of luteinizing hormone-releasing hormone (LHRH...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90643-1
更新日期：1988-01-01 00:00:00
abstract：:This experiment was designed to assess the role of the septo-hippocampal cholinergic (ACh) system in the deleterious effects produced by systemic benzodiazepine injection on learning processes in rats. Retention of a step through passive avoidance task was analysed after systemic injection of increasing doses of eithe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00092-2
更新日期：1999-01-01 00:00:00
abstract：AIMS:Ischemia-reperfusion (I/R) event in vascular and nervous system has been documented to rising ischemic and vasculitic neuropathic pain, clinically resembles the complex regional pain syndrome (CRPS). The present study evaluated the effect of montelukast, a cysteinyl leukotriene receptor (Cys-LTC(4) and Cys-LTD(4))...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.03.010
更新日期：2012-05-22 00:00:00
abstract：:Three distinct peptidyldipeptidases (exopeptidases releasing carboxyl terminal dipeptide residues) can be solubilized from nerve terminal membrane fractions from whole rat brain or striatum, and separated by ion exchange chromatography. Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90435-6
更新日期：1983-01-01 00:00:00
abstract：AIM:The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective estrogen receptor alpha agonist, propyl-pyrazole-triol (PPT) and a selective estrogen receptor beta agonist, diarylpro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.03.010
更新日期：2011-05-09 00:00:00
abstract：:The effect of adrenergic agents on protein phosphorylation in human adipocytes was examined. Freshly isolated human fat cells were incubated with 32PO4 in order to label intracellular ATP, then treated with a variety of adrenergic and other pharmacologic agents. Treatment with the beta-adrenergic agonist isoproterenol...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90597-k
更新日期：1990-01-01 00:00:00
abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119140
更新日期：2021-01-29 00:00:00
abstract：:The acute natriuretic response to atrial peptides (AP) is highly variable in anesthetized rats, and some rats are unresponsive. To determine if this response to AP was affected by dehydration, we measured hematocrit, plasma volume, and natriuresis (delta UNaV) after intravenous injection of 3 micrograms/kg of rat atri...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90149-9
更新日期：1986-06-02 00:00:00
abstract：:Human uridinediphosphate-glucuronosyltransferase 1A1 (UGT1A1) was expressed in Salmonella typhimurium TA1535 cells by transfection of the cells with plasmids carrying the UGT1A1 cDNA. UGT1A1 cDNA was isolated by a polymerase chain reaction from human liver total RNA and was inserted into the pSE420 plasmid, linked to ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00521-x
更新日期：2000-04-07 00:00:00
abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116884
更新日期：2019-12-15 00:00:00
abstract：:Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany. In the present study, to clarify the pharmacological properties of vasodilation produced by GBE, we examined the effect of GBE and quercetin, one of the ingredients in GBE, on the thoracic aorta isola...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01303-0
更新日期：2001-10-05 00:00:00
abstract：:Oxidative stress (free radical generation exceeds antioxidant defense) occurs in many diseases and after exposure to certain chemicals. We automated assays estimating the antioxidant status of serum and lipid hydroperoxide concentrations using the Syva-30R automated analyzer. In this assay, the antioxidant status of s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00401-3
更新日期：1997-01-01 00:00:00
abstract：:A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00277-d
更新日期：1995-01-01 00:00:00
abstract：AIMS:Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been reported to be a novel marker for the progression of chronic kidney disease (CKD). We have recently found that accumulation of ADMA could trigger peritubular capillary loss, thus contributing to tubulointerstitial ischemia ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.03.018
更新日期：2009-06-05 00:00:00
abstract：:Investigated in this study are the effects and mechanisms of exercise and chlorpromazine (CPZ), a widely used conventional antipsychotic drug, on the hepatic insulin sensitivity of 90% pancreatectomized (Px) male Sprague-Dawley rats. The Px diabetic rats were provided with 0, 5, or 50 mg CPZ per kg of body weight (No-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.04.001
更新日期：2007-06-06 00:00:00
abstract：:Rats were made sensitive to the effects of the opioid antagonist naltrexone by treating them once weekly with cumulative doses of the drug (1, 3, 10, 30 and 100 mg/kg). Sensitization was monitored by measuring salivation following naltrexone administration. During the first week of treatment, no salivation was noted f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90341-l
更新日期：1992-01-01 00:00:00
abstract：:Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weigh...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00069-7
更新日期：1999-01-01 00:00:00
abstract：:The effects of erythropoietin (EPO) on cytosolic free calcium concentration ([Ca2+]i) in platelets of 20 essential hypertensive patients (HT) and of 25 normotensive subjects (NT) were investigated using the fura2 technique. In resting platelets [Ca2+]i were not significantly higher in HT compared to NT (74.3 +/- 7.8 n...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90010-m
更新日期：1992-01-01 00:00:00
abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118080
更新日期：2020-09-15 00:00:00
abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2004.05.034
更新日期：2004-11-05 00:00:00
abstract：AIMS:In this study, we used a cross-junction microfluidic device for preparation of alendronate-loaded chitosan nanoparticles with desired characteristics to introduce a suitable element for bone tissue engineering scaffolds. MAIN METHODS:By controlling the reaction condition in microfluidic device, six types of alend...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117768
更新日期：2020-08-01 00:00:00
abstract：AIMS:Carbon nanotube (CNT) membranes offer an exciting opportunity to mimic natural protein channels due to 1) a mechanism of dramatically enhanced fluid flow 2) ability to place 'gatekeeper' chemistry at the entrance to pores 3) the ability for biochemical reactions to occur on gatekeeper molecules and 4) an ability t...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2009.04.006
更新日期：2010-04-10 00:00:00
abstract：:Aminoalkylindoles (AAIs) are structurally dissimilar from the classical cannabinoids (CCs), however, both AAIs and CCs appear to bind at the same site on the cannabinoid receptor. To obtain better insights on the structural correlation between AAIs and CCs, we have studied the conformational properties of the potent c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00177-8
更新日期：1995-01-01 00:00:00
abstract：:Our recent report demonstrated that apoptosis-specific autoantibodies against granzyme B-induced cleavage fragments of SS-B (La) were found in the sera from patients with primary Sjögren's syndrome. The objective of this study was identified by the intracellular redistribution of La autoantigen during granzyme B-induc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.017
更新日期：2007-10-27 00:00:00
abstract：OBJECTIVE:This study aims to evaluate the effective of azoles and MTX for patients with invasive candidiasis. METHODS:We used the disk diffusion assay and the checkerboard assay to evaluate the in vitro interactions between MTX and antifungals. In addition, we used the transmission electron microscopy to observe the u...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116827
更新日期：2019-10-15 00:00:00
abstract：:The potential effect of maternal caffeine ingestion upon total brain protein and the concentration of two prototype neuropeptides, thyrotropin-releasing hormone (TRH) and its derivative, cyclo (His-Pro) in neonates was examined during the nursing period in the context of variable maternal protein intake. Maternal caff...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90332-6
更新日期：1983-11-21 00:00:00
