A novel bacteristatic action of bovine and porcine serum that is reversed by norepinephrine.


:A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition of norepinephrine.


Life Sci


Life sciences


Lenard J,VanDeroef R




Has Abstract


1995-01-01 00:00:00














  • Membrane immunoglobulin: anti-immunoglobulin interactions mediate the phosphorylation of actin associated proteins in the B-lymphocyte.

    abstract::The binding of membrane immunoglobulin (mIg) by anti-Ig antibodies is known to initiate a mitogenic signal in B lymphocytes. Because in many instances growth control appears to be correlated with phosphokinase activity, as well as with alterations in cytoskeletal architecture, we asked the question whether antibodies ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Rosenspire AJ,Choi YS

    更新日期:1988-01-01 00:00:00

  • Mechanism of intranasal drug delivery directly to the brain.

    abstract::Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Crowe TP,Greenlee MHW,Kanthasamy AG,Hsu WH

    更新日期:2018-02-15 00:00:00

  • Synthetic human adrenomedullin and ADM15-52 have potent short-lasting vasodilator activity in the pulmonary vascular bed of the cat.

    abstract::Responses to synthetic human adrenomedullin, a novel hypotensive peptide localized in several organ systems, including the lung, and the carboxy terminal 15-52 amino acid fragment of adrenomedullin (ADM15-52) were investigated in the pulmonary vascular bed of the intact-chest cat. Under constant flow conditions when b...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Cheng DY,DeWitt BJ,Wegmann MJ,Coy DH,Bitar K,Murphy WA,Kadowitz PJ

    更新日期:1994-01-01 00:00:00

  • Different effects of three kinds of somatostatin (15-28, 1-14, 1-28) on rabbit's platelet aggregation.

    abstract::We studied the different effects of three kinds of somatostatin (somatostatin 1-14, somatostatin 15-28, somatostatin 1-28) on the aggregation of rabbit's platelets. It was clarified that somatostatin 15-28 had inhibitory effects on rabbit's platelet aggregation stronger than somatostatin 1-14 did, and that somatostati...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Fuse I,Ito S,Takagi A,Shibata A

    更新日期:1985-05-27 00:00:00

  • The role of the ventromedial hypothalamic area in periprandial glucoregulation.

    abstract::There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Storlien LH

    更新日期:1985-02-11 00:00:00

  • circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3/ATG7-activated autophagy in a rat model of myocardial infarction.

    abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

    更新日期:2020-09-15 00:00:00

  • Bone morphogenetic protein-2 induces the differentiation of a mesenchymal progenitor cell line, ROB-C26, into mature osteoblasts and adipocytes.

    abstract:AIMS:Osteoblasts and adipocytes originate from common precursor cells. We examined the effects of bone morphogenetic protein-2 (BMP-2) on the molecular mechanisms governing the diametric actions of BMP-2 on simultaneous mature osteoblast and adipocyte differentiation in a clonal mesenchymal progenitor cell line, ROB-C2...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kato S,Kawabata N,Suzuki N,Ohmura M,Takagi M

    更新日期:2009-02-27 00:00:00

  • Differential sensitivity to cocaine in spontaneously hypertensive and Wistar-Kyoto rats.

    abstract::Physiological, pharmacological and toxicological responses to two regimens of cocaine administration were compared between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. An initial experiment examined renal excretory and hemodynamic function in response to an acute volume load in anesthetized SHR and WK...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ishizuka Y,Rockhold RW,Kirchner K,Hoskins B,Ho IK

    更新日期:1989-01-01 00:00:00

  • Essential oils components as a new path to understand ion channel molecular pharmacology.

    abstract::The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, na...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: de Araújo DA,Freitas C,Cruz JS

    更新日期:2011-10-10 00:00:00

  • Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test.

    abstract:AIMS:Recent evidence has shown that systemic administration of sulfonylureas and biguanides block the diclofenac-induced antinociception, but not the effect produced by indomethacin. However, there are no reports about the peripheral interaction between analgesics and the biguanides metformin and phenformin. Therefore,...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ortiz MI

    更新日期:2012-01-02 00:00:00

  • Streptozotocin-induced diabetes increases fructose 2,6-biphosphate levels and glucose metabolism in thymus lymphocytes.

    abstract::Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

    更新日期:1996-01-01 00:00:00

  • Chronic intermittent hypoxia stimulates testosterone production in rat Leydig cells.

    abstract:AIMS:The hypoxia-stimulated response of the endocrine system depends on the kind and duration of hypoxia. Hypoxia has been reported to stimulate testosterone (T) production in rats, but the mechanisms remain to be investigated. MATERIALS AND METHODS:Male rats were divided into two groups. The rats exposed to chronic i...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Cho YM,Chou JC,Fang CM,Hu S,Wang KL,Wang SW,Wang PS

    更新日期:2019-09-15 00:00:00

  • Striatal dopamine release and biphasic pattern of locomotor and motor activity under gas narcosis.

    abstract::Inert gas narcosis is a neurological syndrome appearing when humans or animals are exposed to hyperbaric inert gases (nitrogen, argon) composed by motor and cognitive impairments. Inert gas narcosis induces a decrease of the dopamine release at the striatum level, structure involved in the regulation of the extrapyram...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Balon N,Risso JJ,Blanc F,Rostain JC,Weiss M

    更新日期:2003-05-02 00:00:00

  • Combined effects of aging and in vitro non-steroid anti-inflammatory drugs on kidney and liver mitochondrial physiology.

    abstract:AIMS:Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. We...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Rocha-Rodrigues S,Santos-Alves E,Coxito PM,Marques-Aleixo I,Passos E,Guimarães JT,Martins MJ,Oliveira PJ,Magalhães J,Ascensão A

    更新日期:2013-09-03 00:00:00

  • Hepatic mitochondrial enzyme activity and serum amino acid composition in rats treated with tumor necrosis factor.

    abstract::The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Yasmineh WG,Tsai MY,Theologides A

    更新日期:1995-01-01 00:00:00

  • Enhanced vesiculation exacerbates complement-dependent hemolysis in glucose-6-phosphate dehydrogenase deficient red blood cells.

    abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficien...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Tsai KJ,Shih LY,Hung IJ,Huang SW,Wei JS,Liu TZ,Chiu DT

    更新日期:1996-01-01 00:00:00

  • The benefits of coffee on skeletal muscle.

    abstract::Coffee is consumed worldwide with greater than a billion cups of coffee ingested every day. Epidemiological studies have revealed an association of coffee consumption with reduced incidence of a variety of chronic diseases as well as all-cause mortality. Current research has primarily focused on the effects of coffee ...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Dirks-Naylor AJ

    更新日期:2015-12-15 00:00:00

  • Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors.

    abstract:AIMS:The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by melatonin and serotonin. Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic agonist and ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Yang J,Jin HJ,Mocaër E,Seguin L,Zhao H,Rusak B

    更新日期:2016-06-15 00:00:00

  • Effects of amiodarone on rodent ventricular cardiomyocytes: Novel perspectives from a cellular model of Long QT Syndrome Type 3.

    abstract:AIMS:Amiodarone (AMIO) is currently used in medical practice to reverse ventricular tachycardia. Here we determine the effects of AMIO in the electromechanical properties of isolated left ventricle myocyte (LVM) from mice and guinea pig and in a cellular model of Long QT Syndrome Type 3 (LQTS-3) using anemone neurotoxi...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Beserra SS,Santos-Miranda A,Sarmento JO,Miranda VM,Roman-Campos D

    更新日期:2020-08-15 00:00:00

  • Ergothioneine ameliorates oxaliplatin-induced peripheral neuropathy in rats.

    abstract:AIMS:Oxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect. It is reported that this peripheral neuropathy results from l-OHP accumulation in dorsal root ganglion (DRG) neurons, and that one of the...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Nishida K,Takeuchi K,Hosoda A,Sugano S,Morisaki E,Ohishi A,Nagasawa K

    更新日期:2018-08-15 00:00:00

  • Molecular mechanisms underlying anticancer effects of myricetin.

    abstract::Dietary guidelines published in the past two decades have acknowledged the beneficial effects of myricetin, an important and common type of herbal flavonoid, against several human diseases such as inflammation, cardiovascular pathologies, and cancer. An increasing number of studies have shown the beneficial effects of...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Devi KP,Rajavel T,Habtemariam S,Nabavi SF,Nabavi SM

    更新日期:2015-12-01 00:00:00

  • Neurobiology of opioid withdrawal: Role of the endothelin system.

    abstract::Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Bhalla S,Andurkar SV,Gulati A

    更新日期:2016-08-15 00:00:00

  • Calcium-independent CaMKII activity is involved in ginsenoside Rb1-mediated neuronal recovery after hypoxic damage.

    abstract::Recent studies have indicated that Ginsenoside Rb1, one of the major components of ginseng root, may play an important role in protecting cells from damage. Here, we investigated the neuroprotective activity of Rb1 after hypoxic injury in young rats. About 50% animals were dead by exposing hypoxic condition three time...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Park JK,Namgung U,Lee CJ,Park JO,Jin SH,Kwon OB,Ko SR,Kim SW,Kang EJ,Ko JH,Lee SM,Kim DH,Won MH

    更新日期:2005-01-14 00:00:00

  • Effect of 12, 24 and 72 hours fasting in thermogenic parameters of rat brown adipose tissue mitochondrial subpopulations.

    abstract::The aim of the present work was to study the effects of various durations of fasting (12, 24 and 72 hours) on brown adipose tissue (BAT) thermogenic parameters--cytrochrome-c-oxidase (COX) activity, GDP-binding activity and uncoupling protein (UCP1) content--and also on morphological features of different mitochondria...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Gianotti M,Clapés J,Lladó I,Palou A

    更新日期:1998-01-01 00:00:00

  • Effects of nicotine on proliferation and osteoblast differentiation in human alveolar bone marrow-derived mesenchymal stem cells.

    abstract:AIMS:Nicotine is a risk factor for various diseases, including osteoporosis, oral cancer, and periodontal disease. Numerous studies have elucidated the effects of nicotine on cell proliferation and differentiation. The purpose of this study was to determine the effects of nicotine on the proliferation and osteoblast di...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kim BS,Kim SJ,Kim HJ,Lee SJ,Park YJ,Lee J,You HK

    更新日期:2012-01-16 00:00:00

  • Selective G2/M arrest in a p53(Val135)-transformed cell line induced by lithium is mediated through an intricate network of MAPK and β-catenin signaling pathways.

    abstract:AIMS:Lithium is a common mood stabilizer to treat bipolar disorder. It has a narrow window of therapeutic action and its mechanism of action and possible side effects are still not fully understood. Lithium is a potent inhibitor of glycogen synthase kinase 3β (GSK-3β). Previous studies indicated that lithium can induce...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Tsui MM,Tai WC,Wong WY,Hsiao WL

    更新日期:2012-09-24 00:00:00

  • Effects of all-trans-retinoic acid on the permeability transition and bioenergetic functions of rat liver mitochondria in combination with endoxifen.

    abstract:AIMS:The clinical utilization of the combinations of all-trans-retinoic acid (RA) with antiestrogens, which present synergism of action in breast cancer, has been limited by RA adverse effects, including hepatotoxicity, which may be related with mitochondrial damage. This work evaluated the effects of RA alone and in c...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ribeiro MP,Santos AE,Santos MS,Custódio JB

    更新日期:2013-07-30 00:00:00

  • Dual in vitro effects of cortisol on cell turnover in the medaka esophagus via the glucocorticoid receptor.

    abstract:AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

    更新日期:2011-01-31 00:00:00

  • The appropriate remodeling of extracellular matrix is the key molecular signature in subcutaneous adipose tissue following Roux-en-Y gastric bypass.

    abstract:AIMS:We sought to reveal the key molecular signature in subcutaneous adipose tissue (scAT) following Roux-en-Y gastric bypass (RYGB), through bioinformatics analysis and further verification in vivo. MAIN METHODS:We obtained a transcriptome data of scAT from RYGB and sham-operated rats from the Gene Expression Omnibus...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Chen X,Gong L,Li Q,Hu J,Liu X,Wang Y,Bai J,Ran X,Wu J,Ge Q,Li R,Xiao X,Li X,Zhang J,Wang Z

    更新日期:2019-02-01 00:00:00

  • Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies.

    abstract:BACKGROUND:The prevalence and mortality of the outbreak of the COVID-19 pandemic show marked geographic variation. The presence of several subtypes of the coronavirus and the genetic differences in the populations could condition that variation. Thus, the objective of this study was to propose variants in genes that en...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Vargas-Alarcón G,Posadas-Sánchez R,Ramírez-Bello J

    更新日期:2020-11-01 00:00:00