Abstract：
AIMS:Carbon nanotube (CNT) membranes offer an exciting opportunity to mimic natural protein channels due to 1) a mechanism of dramatically enhanced fluid flow 2) ability to place 'gatekeeper' chemistry at the entrance to pores 3) the ability for biochemical reactions to occur on gatekeeper molecules and 4) an ability to chemically functionalize each side of the membrane independently. MAIN METHODS:Aligned CNT membranes were fabricated and CNT pore entrances modified with gatekeeper chemistry. Pressure driven fluid flow and diffusion experiments were performed to study the mechanisms of transport through CNTs. KEY FINDINGS:The transport mechanism through CNT membranes is primarily 1) ionic diffusion near bulk expectation 2) gas flow enhanced 1-2 orders of magnitude primarily due to specular reflection 3) fluid flow 4-5 orders of magnitude faster than conventional materials due to a nearly ideal slip-boundary interface. The transport can be modulated by 'gatekeeper' chemistry at the pore entrance using steric hindrance, electrostatic attraction/repulsion, or biochemical state. The conformation of charged tethered molecules can be modulated by applied bias setting the stage for programmable drug release devices. SIGNIFICANCE:The membrane structure is mechanically far more robust than lipid bilayer films, allowing for large-scale chemical separations, delivery or sensing based on the principles of protein channels. The performance of protein channels is several orders of magnitude faster than conventional membrane materials. The fundamental requirements of mimicking protein channels are present in the CNT membrane system.
journal_name
Life Scijournal_title
Life sciencesauthors
Majumder M,Stinchcomb A,Hinds BJdoi
10.1016/j.lfs.2009.04.006subject
Has Abstractpub_date
2010-04-10 00:00:00pages
563-8issue
15-16eissn
0024-3205issn
1879-0631pii
S0024-3205(09)00163-5journal_volume
86pub_type
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