Abstract：
:Uptake of serotonin and 3H-imipramine binding in platelets of depressed patients were investigated simultaneously with changes in clinical state. Both Vmax for serotonin uptake and Bmax for 3H-imipramine binding were significantly lower in unmedicated depressed patients with respect to normal subjects. Successful treatment with imipramine led to a significant increase in Bmax for 3H-imipramine binding, without significant change in Vmax for serotonin uptake. Bmax values increased to the normal range following complete, rather than partial clinical improvement. These data indicate that successful antidepressant treatment may increase the density of 3H-imipramine binding sites on platelets by a process which is independent of the uptake of serotonin.
journal_name
Life Scijournal_title
Life sciencesauthors
Suranyi-Cadotte BE,Quirion R,Nair NP,Lafaille F,Schwartz Gdoi
10.1016/0024-3205(85)90201-2subject
Has Abstractpub_date
1985-02-25 00:00:00pages
795-9issue
8eissn
0024-3205issn
1879-0631pii
0024-3205(85)90201-2journal_volume
36pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Definition of the physiological and pharmacological properties of primary afferent neurons by the use of capsaicin and its analogues (e.g. resiniferatoxin) has represented one of the most active areas of research of the last decade (1-4 for reviews). In the past 3 years many important advancements have been made in th...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(91)90169-c
更新日期：1991-01-01 00:00:00
abstract：:Liver fibrosis is a global health issue that causes morbidity and mortality with no currently available treatment. It has been shown that low dose paclitaxel (PTX) can stabilize microtubules and inhibit the profibrotic transforming growth factor-beta 1 (TGF-β1) signaling pathway. In this study the effect of treatment ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.09.037
更新日期：2018-10-15 00:00:00
abstract：AIMS:To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression. MATERIALS AND METHODS:Stereotaxic surgery was performed here to establish a rat model by bi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117828
更新日期：2020-08-15 00:00:00
abstract：:The use of more than one drug to achieve a desired effect has been a common practice in pharmacologic testing and in clinical practice. For example, combinations of analgesics are frequently prescribed with a view to enhancing pain relief and reducing adverse effects. It is also well established that administration of...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(89)90148-3
更新日期：1989-01-01 00:00:00
abstract：:Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2006.05.017
更新日期：2006-09-20 00:00:00
abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90551-4
更新日期：1984-03-26 00:00:00
abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117429
更新日期：2020-04-15 00:00:00
abstract：:A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90220-w
更新日期：1993-01-01 00:00:00
abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00495-e
更新日期：1995-01-01 00:00:00
abstract：:In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90827-5
更新日期：1983-04-11 00:00:00
abstract：:In our previous paper (Biochem. Biophys. Res. Commun. 141, 20-26 (1986) we reported the isolation of a 34000-dalton protein (p34K) which binds to calmodulin and F-actin from chicken gizzard smooth muscle. We examined the distribution of the immunoreactive component of gizzard p34K in bovine tissues by immunoblot analy...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90151-2
更新日期：1987-07-20 00:00:00
abstract：:Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val, melanin concentrating hormone (MCH), is a cyclic hormone possessing both MCH-like (melanin granule aggregating effect) and melanocyte stimulating hormone (MSH)-like (melanin granule dispersing effect) activities. Nine ring-contracted analogues were s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90460-8
更新日期：1989-01-01 00:00:00
abstract：:Previous studies from this laboratory have shown that rats with experimental cirrhosis of the liver induced by the combined administration of oral phenobarbital and inhaled carbon tetrachloride show an hyperdynamic status with enhanced cardiac output (CO), and decreased mean arterial pressure (MAP) and peripheral vasc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90531-x
更新日期：1986-07-21 00:00:00
abstract：:Psoriasis is an inflammatory skin disease with preference for the skin and joints that occurs due to hyper-proliferation and abnormal apoptosis of keratinocytes. DUSP1 expression in dermal mesenchymal stem cells (MSCs) is obviously lower in psoriasis patients than that in healthy individuals. The present study aimed t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.018
更新日期：2019-04-15 00:00:00
abstract：AIMS:We have developed biochemical and cell based assays to characterize small therapeutic molecules that inhibit the DNA damage checkpoint enzyme, Chk1 (Checkpoint kinase 1). MAIN METHODS:To prepare a screen of large chemical libraries, we purified the full-length and the catalytic domain versions of human Chk1. We c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.06.010
更新日期：2011-08-15 00:00:00
abstract：:Synthetic nitric oxide donors are known to protect the gastric mucosa from damage and dietary nitrate is known to release NO in the stomach. Mast cells have been found to be involved in gastric mucosal damage in humans or in rodents, and recent studies have pointed out the possibility of nitric oxide from endogenous o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00480-6
更新日期：2003-08-08 00:00:00
abstract：AIMS:The present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite. MATERIALS AND METHODS:Firstly, the biological activity of rhBMP-2 and rhCXCL13 rele...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116743
更新日期：2019-10-01 00:00:00
abstract：AIMS:Oxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect. It is reported that this peripheral neuropathy results from l-OHP accumulation in dorsal root ganglion (DRG) neurons, and that one of the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.006
更新日期：2018-08-15 00:00:00
abstract：:Studies have reported that taraxasterol (TAR) is effective in the treatment of immune liver injury and alcoholic liver injury. The mechanism of action is mainly related to the inhibition of inflammation. To determine the key molecular mechanisms for the effect of TAR on alleviating ethanol and high-fat diet-induced li...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118546
更新日期：2020-12-01 00:00:00
abstract：:Gloriosaols A-C, isolated from Yucca gloriosa (Agavaceae), are novel phenolic compounds structurally related to resveratrol. In the present study, we show that gloriosaols possess antiproliferative and pro-apoptotic activity on tumor cells of different histogenetic origin and that their cell growth inhibition potentia...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.07.010
更新日期：2007-08-23 00:00:00
abstract：:Peripheral blood cells express the complete non-neuronal cholinergic system. For example synthesis of acetylcholine and nicotinic as well muscarinic receptors have been demonstrated in leucocytes isolated from human peripheral blood. In the present experiments mononuclear cells and granulocytes were isolated from the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.01.010
更新日期：2007-05-30 00:00:00
abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90475-x
更新日期：1989-01-01 00:00:00
abstract：:The beta-endorphin, met5-enkephalin-arg6-phe7 (MEAP) and met5-enkephalin (ME) changes related to age and diurnal rhythms were studied in various regions of rat brain and in the pituitary by specific radioimmunoassays. The contents of MEAP, met5-enkephalin and beta-endorphin were higher in the pituitary of old rats (18...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90667-2
更新日期：1984-08-27 00:00:00
abstract：:Glucocorticoids (GCs) are hormones with anti-inflammatory and immuno-suppressive effects. The use of hormonal medicine like GCs may cause systemic adverse effects. In the present study, the cellular response of murine pre-osteoclast cell line RAW264.7 to dexamethasone (DEX) was investigated and the result demonstrated...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.10.012
更新日期：2008-01-16 00:00:00
abstract：:Although one of the major genes which cause type 1 (insulin-dependent) diabetes mellitus is located in the class II HLA region in humans, its precise location is still unknown. In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00713-6
更新日期：1994-01-01 00:00:00
abstract：:The effect of the three forms (CANP1, CANP2 & CANP3) of calf brain calcium activated neutral protease (CANP) on the hydrolysis of purified neurofilament triplet proteins was investigated. It was observed that: each of the purified neurofilament proteins, was hydrolyzed slowly by CANP2 whereas the hydrolysis of 150 KDa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90331-0
更新日期：1986-10-13 00:00:00
abstract：:In this study we examined if sleep time, caloric intake and energy expenditure are important contributors to development of ovariectomy-induced obesity in mice fed control or high fat diet (HFD). Twelve female mice at 6 weeks of age were divided into 2 groups: Sham (n = 5) and ovariectomized (OVX, n = 7). Mice were fe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.09.034
更新日期：2018-11-01 00:00:00
abstract：AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118749
更新日期：2021-01-15 00:00:00
abstract：:The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90085-6
更新日期：1990-01-01 00:00:00
abstract：:Met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area CA 3-4 in the hippocampus of both young and aged Fisher 344 rats than it did in the CA 1 area. Furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90360-2
更新日期：1987-01-12 00:00:00
