A role for the autonomic nervous system in modulating the immune response during mild emotional stimuli.

abstract：AIMS:The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. MATERIALS AND METHODS:circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression...

journal_title：Life sciences

authors： Zou J,Liu KC,Wang WP,Xu Y

更新日期：2020-09-01 00:00:00

abstract：:The purpose of the present studies was to investigate the activity of the adrenal gland and the pituitary beta-endorphin system in individuals from families with a 3 generation history of alcoholism, High Risk group, or from families without history of alcoholism, Low Risk group. All subjects had a medical examination...

journal_title：Life sciences

authors： Gianoulakis C,Béliveau D,Angelogianni P,Meaney M,Thavundayil J,Tawar V,Dumas M

更新日期：1989-01-01 00:00:00

abstract：AIM:The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective estrogen receptor alpha agonist, propyl-pyrazole-triol (PPT) and a selective estrogen receptor beta agonist, diarylpro...

journal_title：Life sciences

authors： Baraka AM,Korish AA,Soliman GA,Kamal H

更新日期：2011-05-09 00:00:00

abstract：:Human alpha-fetoprotein (AFP) was expressed in Saccharomyces cerevisiae, with a plasmid containing the cDNA sequence for human AFP fused with the rat AFP signal peptide. The recombinant AFP was purified from the yeast lysate by DEAE-cellulose and immunoaffinity chromatography. The amino acid composition and the molecu...

journal_title：Life sciences

authors： Yamamoto R,Sakamoto T,Nishi S,Sakai M,Morinaga T,Tamaoki T

更新日期：1990-01-01 00:00:00

abstract：AIMS:The antihypertensive mechanism (s) of the epigallocatechin-3-gallate (EGCG), a major effective component in green tea, might associate with microRNAs (miRNAs). Here, we aimed to investigate which microRNA in aorta of spontaneously hypertensive rats (SHRs) were modulated by administration of EGCG and its mechanism....

journal_title：Life sciences

authors： Qian BJ,Tian CC,Ling XH,Yu LL,Ding FY,Huo JH,Zhu LC,Wen YL,Zhang JH,Jing P

更新日期：2018-06-15 00:00:00

abstract：:Dose-effect curves were obtained for five specific components of stereotyped behavior (locomotor hyperactivity, rearing, sniffing, grooming and oral activity) elicited by the nonselective dopamine agonists N-propylnorapomorphine (NPA; 0.001-4.5 mg/kg) and apomorphine (APO; 0.3-10.0 mg/kg), the selective D2 agonists LY...

journal_title：Life sciences

authors： Meller E,Bordi F,Bohmaker K

更新日期：1988-01-01 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the ...

journal_title：Life sciences

authors： Duerr GD,Feißt A,Halbach K,Verfuerth L,Gestrich C,Wenzel D,Zimmer A,Breuer J,Dewald O

更新日期：2018-12-15 00:00:00

abstract：:The effects of C-reactive protein (CRP), the prototypical acute-phase reactant were studied on human polymorphonuclear leukocytes (PMNL) challenged with N-formyl-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF). CRP at 8-64 micrograms/ml concentrations inhibited degranulation and superoxide p...

journal_title：Life sciences

authors： Filep J,Földes-Filep E

更新日期：1989-01-01 00:00:00

abstract：:Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA). Tyr metabolism has been studied in users of the new generation combined ...

journal_title：Life sciences

authors： Møller SE,Maach-Møller B,Olesen M,Madsen B,Madsen P,Fjalland B

更新日期：1995-01-01 00:00:00

abstract：:XY99-5038 is a preparation from a specific formula provided by Dr. Yan Xin, a renowned Traditional Chinese Medicine specialist. This formulation has proven to be effective without side effects but has not been studied under rigorous laboratory conditions. In order to investigate the role of XY99-5038 in protecting neu...

journal_title：Life sciences

authors： Xin Y,Fong YT,Wolf G,Wolf D,Cao W

更新日期：2001-06-08 00:00:00

abstract：:Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...

journal_title：Life sciences

authors： Barrios V,Urrutia MJ,Hernández M,Lama R,García-Novo MD,Hernanz A,Arilla E

更新日期：1994-01-01 00:00:00

abstract：:Relationship between in vivo down-regulation of cardiac muscarinic receptors and changes in their encoding mRNA was investigated. Rats were treated either once or for ten days with an irreversible inhibitor of acetylcholinesterase, followed by measurements of cardiac acetylcholinesterase, the density and affinity of m...

journal_title：Life sciences

authors： Zhu SZ,Wang SZ,Abdallah EA,el-Fakahany EE

更新日期：1991-01-01 00:00:00

abstract：:Efficacy of chemotherapy may be maximized and its toxicity can be minimized if drugs would be administered at specified daily times. The present study was aimed to examine if the protection of amifostine against cisplatin toxicity is time dependent. Amifostine is an organic thiophosphate that protects selectively norm...

journal_title：Life sciences

authors： Asna N,Lewy H,Ashkenazi IE,Deutsch V,Peretz H,Inbar M,Ron IG

更新日期：2005-03-04 00:00:00

abstract：:Central administration of neurotensin (NT) results in a variety of neurobehavioral effects which, depending upon the administration site, resemble the effects of antipsychotic drugs (APDs) and psychostimulants. All clinically effective APDs exhibit significant affinities for dopamine D(2) receptors, supporting the hyp...

journal_title：Life sciences

authors： Dobner PR,Deutch AY,Fadel J

更新日期：2003-06-27 00:00:00

abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...

journal_title：Life sciences

authors： Lei Y,Peng X,Li T,Liu L,Yang G

更新日期：2019-01-01 00:00:00

abstract：:Benzodiazepines are frequently used for the treatment of maternal psychiatric disorders during pregnancy. Besides their anxiolytic effect, they are reported to exert a direct relaxing action on several smooth muscle preparations, including the uterus. In the present study, the possibility of the involvement of alpha(1...

journal_title：Life sciences

authors： Zupkó I,Jánossy K,Maul K,Márki A,Falkay G

更新日期：2003-01-24 00:00:00

abstract：:11Beta-hydroxyglucocorticoids (HGCs) are known to induce apoptosis in immature T cells. Here we show that 11-oxoglucocorticoids (OGCs), which are oxidized metabolites of HGCs, counteract the apoptosis-inducing effects of HGC in murine thymocytes in vitro. Corticosterone at concentrations ranging from 0.1-100 microM in...

journal_title：Life sciences

authors： Hirano T,Horigome H,Ishishita H,Uda S,Oka K

更新日期：2001-05-18 00:00:00

abstract：:Recent findings indicate that low concentrations of dopamine (DA) stimulate the secretion of prolactin (PRL) in vitro. In this study, we found that low concentrations of the highly-specific DA D2 receptor agonist, quinpirole hydrochloride (LY) stimulate PRL secretion in female rats, assessed by reverse hemolytic plaqu...

journal_title：Life sciences

authors： Niimi M,Takahara J,Sato M,Murao K,Kawanishi K

更新日期：1993-01-01 00:00:00

abstract：:Respiratory performance, heart rate and blood pressure were studied in halothane anesthetized rats after administration of taurine and the putative taurine antagonist 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1, 1-dioxide hydrochloride (TAG). Intracerebroventricular (i.c.v.) taurine depressed ventilation due to...

journal_title：Life sciences

authors： Wessberg P,Hedner T,Hedner J,Jonason J

更新日期：1983-10-24 00:00:00

abstract：:Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...

journal_title：Life sciences

authors： Zhang Y,Zhu H,Ye G,Huang C,Yang Y,Chen R,Yu Y,Cui X

更新日期：2006-03-20 00:00:00

abstract：:The object of this study was to develop an assay for platelet activating factor (PAF) in rat plasma, and to utilise this to determine the effects of dietary fish oil on PAF in normotensive and spontaneously hypertensive rats. Measurement of platelet activating factor in blood plasma has proved difficult because of its...

journal_title：Life sciences

authors： Croft KD,Sturm MJ,Codde JP,Vandongen R,Beilin LJ

更新日期：1986-05-19 00:00:00

abstract：:Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation. The present study was conducted to confirm that uric acid values in serum could be an efficient marker of ischemic injury of liver parenchyma following...

journal_title：Life sciences

authors： Kogure K,Ishizaki M,Nemoto M,Kuwano H,Tatemoto K,Maruyama Y,Ikarashi Y,Makuuchi M

更新日期：1999-01-01 00:00:00

abstract：:Active uptake of serotonin (5-hydroxytryptamine, 5-HT) into blood platelets from healthy donors exhibited a lower Vmax value in buffer media than in plasma. Also in plasma ultrafiltrate Vmax was reduced, but it returned to the level measured in plasma upon addition of human serum albumin (40 milligrams) containing fat...

journal_title：Life sciences

authors： Breyer-Pfaff U,Fauss C,Böhne HP

更新日期：1989-01-01 00:00:00

abstract：:Dopamine inhibited basal, TRH-, IBMX- and A23187-stimulated prolactin secretion from rat anterior pituitary cells. However, dopamine did not inhibit prolactin secretion stimulated by elevated K+ concentrations. These data are interpreted in terms of dopaminergic inhibition of both cyclic AMP production and Ca2+ influx...

journal_title：Life sciences

authors： Merritt JE,Brown BL

更新日期：1984-08-13 00:00:00

abstract：AIMS:We examined the nature of pharmacological interaction after coadministration of melatonin with clonidine or neostigmine on formalin-induced nociception at the spinal level. Further, the role of melatonin receptor subtypes in melatonin-induced antinociception was clarified. MAIN METHODS:Catheters were inserted int...

journal_title：Life sciences

authors： Yoon MH,Park HC,Kim WM,Lee HG,Kim YO,Huang LJ

更新日期：2008-12-19 00:00:00

abstract：:This study was undertaken to investigate whether or not alpha 2-adrenergic pathways would negatively modulate the hypothalamic somatostatin release in rats. To induce pharmacological changes in SS release, three groups of male Sprague-Dawley rats (n = 30/group) were separately anesthetized by ip administration of uret...

journal_title：Life sciences

authors： Lima L,Arce V,Tresguerres JA,Devesa J

更新日期：1993-01-01 00:00:00

abstract：:We evaluated the effect of several classes of calmodulin inhibitors on the activity of calmodulin prepared from C6 astrocytoma cells and studied the activity of these drugs as inhibitors of the growth of C6 cells in tissue culture. There was a good correlation between the activity of the drugs as inhibitors of calmodu...

journal_title：Life sciences

authors： Lee GL,Hait WN

更新日期：1985-01-28 00:00:00

abstract：AIMS:Obesity is not only associated with metabolic diseases but is also a symptom of menopause in women. To date, there are no effective drugs for the management of obesity, and it is important to find new agents with fewer side effects, for the treatment of obesity. This study aimed to determine the anti-obesity effec...

journal_title：Life sciences

authors： Tsai YC,Leu SY,Chen SY,Kung CW,Lee YM,Liu YP,Yen MH,Cheng PY

更新日期：2019-09-01 00:00:00

abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...

journal_title：Life sciences

authors： Chaudhary SC,Alam MS,Siddiqui MS,Athar M

更新日期：2009-07-31 00:00:00

abstract：:Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...

journal_title：Life sciences

authors： Pan H,Zhao F,Yang Y,Chang N

更新日期：2020-08-01 00:00:00