Abstract:
:Benzodiazepines are frequently used for the treatment of maternal psychiatric disorders during pregnancy. Besides their anxiolytic effect, they are reported to exert a direct relaxing action on several smooth muscle preparations, including the uterus. In the present study, the possibility of the involvement of alpha(1)-adrenergic receptors in this peripheral effect is investigated. The tocolytic potencies of diazepam, midazolam and nitrazepam are assessed in vivo in a postpartum rat model, together with other drugs known to bind to alpha-adrenoceptors (e.g. alpha(1)-antagonists, tricyclic compounds and droperidol). The interactions of some benzodiazepines and norepinephrine were also examined in an isolated in vitro system. The affinities of these agents for the receptor in question were additionally tested by radioligand displacement assay. A correlation was found between the tocolytic potencies and inhibition constants of the tested drugs, suggesting that the smooth muscle-relaxing effect of these benzodiazepines is mediated through modulation of the alpha(1)-adrenergic receptors.
journal_name
Life Scijournal_title
Life sciencesauthors
Zupkó I,Jánossy K,Maul K,Márki A,Falkay Gdoi
10.1016/s0024-3205(02)02306-8subject
Has Abstractpub_date
2003-01-24 00:00:00pages
1093-102issue
10eissn
0024-3205issn
1879-0631pii
S0024320502023068journal_volume
72pub_type
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