Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl ATP, a photoaffinity label.

Abstract:

:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the bladders with visible light during the infusion of ANAPP3 resulted in a blockade of the response for at least 120 minutes. Thus, photoactivation of ANAPP3 in vivo produced an essentially irreversible blockade of P2-purinergic receptors.

journal_name

Life Sci

journal_title

Life sciences

authors

Theobald RJ Jr,Hoffman V

doi

10.1016/0024-3205(86)90498-4

subject

Has Abstract

pub_date

1986-04-28 00:00:00

pages

1591-5

issue

17

eissn

0024-3205

issn

1879-0631

pii

0024-3205(86)90498-4

journal_volume

38

pub_type

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