Abstract:
:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the bladders with visible light during the infusion of ANAPP3 resulted in a blockade of the response for at least 120 minutes. Thus, photoactivation of ANAPP3 in vivo produced an essentially irreversible blockade of P2-purinergic receptors.
journal_name
Life Scijournal_title
Life sciencesauthors
Theobald RJ Jr,Hoffman Vdoi
10.1016/0024-3205(86)90498-4subject
Has Abstractpub_date
1986-04-28 00:00:00pages
1591-5issue
17eissn
0024-3205issn
1879-0631pii
0024-3205(86)90498-4journal_volume
38pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The available preclinical literature on the antihyperlipidemic properties of beta-pyridylcarbinol is reviewed. Similarities between the pharmacological profiles for beta-pyridylcarbinol and nicotinic acid, and evidence for the metabolic conversion of beta-pyridylcarbinol to nicotinic acid are discussed. Several review...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(85)90026-8
更新日期:1985-11-25 00:00:00
abstract:AIMS:The recent outbreak of pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led the world towards a global health emergency. Currently, no proper medicine or effective treatment strategies are available; therefore, repurposing of FDA approved drugs may play an important role in overcoming the ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118169
更新日期:2020-10-15 00:00:00
abstract::Further confirmation that the LHRH/LHRH agonist-induced ovulation in the hypophysectomized (hypx) rat is due to a direct ovarian effect and not mediated by LH release from residual pituitary tissue or other CNS sites is provided by the persistence of this effect despite concomitant median eminence lesion or passive im...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90663-5
更新日期:1984-08-27 00:00:00
abstract:AIMS:Interleukin-1β (IL-1β) is a cytokine that is known to activate the stress axis and suppress the reproductive axis. Different brain areas are involved in the regulation of these two axes. However, they are both under the stimulatory control of the catecholamine, norepinephrine (NE). Here, we hypothesized that IL-1β...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.09.004
更新日期:2012-10-29 00:00:00
abstract::The metabolism of benzene and toluene was investigated in preparations of human bone marrow incubated with S-adenosyl-L-methionine. Benzene undergoes a methyl-substitution reaction to yield toluene as a metabolite. Furthermore, toluene undergoes methyl-substitution in preparations of human bone marrow incubated with S...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90100-p
更新日期:1991-01-01 00:00:00
abstract::There are many studies of the mechanisms of antidepressants; however, most of these studies were conducted on the hippocampus or frontal cortex. In the present study, we hypothesized that the nucleus accumbens and caudate/putamen might be major targets for antidepressant effects. Thus, we focused on G(olf) protein, a ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.01.033
更新日期:2006-06-27 00:00:00
abstract::Almost all diabetic complications are known to be associated with vascular dysfunctions of different tissues. Oxidative stress, on the other hand, has been implicated in the pathogenesis of diabetes mellitus. Therefore in the present study we have investigated the correlation between redox status and oxidative stress ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00662-3
更新日期:2003-10-03 00:00:00
abstract::Significant labelled dopamine uptake was evident in bone marrow, spleen and lymph nodes of normal murine hosts in vivo. On the contrary animals bearing solid Ehrlich carcinoma, 3H-dopamine uptake was significantly reduced. The tumor tissue itself incorporated only insignificant amount of dopamine. Bone marrow cells, s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90645-j
更新日期:1993-01-01 00:00:00
abstract::We examined the effects of cyrneine A, a novel diterpene isolated from the mushroom Sarcodon cyrneus, on morphology of rat pheochromocytoma cells (PC12). In response to cyrneine A, PC12 cells extended their neurites, an effect partially blocked by the extracellular signal-regulated kinase (ERK) kinase inhibitor PD9805...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.01.057
更新日期:2007-04-10 00:00:00
abstract::The best conditions for extractions of free pyrroloquinoline quinone (PQQ) from crude biological samples were investigated with various organic solvents and Sep-Pak C18 cartridges. PQQ was measured with use of its native fluorescence in aqueous solution. PQQ was well extracted into n-butanol under acid conditions, and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90313-g
更新日期:1990-01-01 00:00:00
abstract:AIM:This study aimed to evaluate the effects of Wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), on aortic hyporeactivity to Phenylephrine (Phe) and nitric oxide bioavailability associated with pregnancy in hypertensive rats. MAIN METHODS:The intact aortic rings of pregnant and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.12.014
更新日期:2015-02-01 00:00:00
abstract::Benzodiazepines are frequently used for the treatment of maternal psychiatric disorders during pregnancy. Besides their anxiolytic effect, they are reported to exert a direct relaxing action on several smooth muscle preparations, including the uterus. In the present study, the possibility of the involvement of alpha(1...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02306-8
更新日期:2003-01-24 00:00:00
abstract:AIM:To investigate the cytotoxic effect of Peruvoside and mechanism of action in human cancers. MAIN METHODS:Cell viability was measured by MTT assay and the cell cycle arrest was identified by FACS. Real-time qPCR and western blotting studies were performed to identify important gene and protein expressions in the di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117147
更新日期:2020-01-15 00:00:00
abstract::Cloned human MCF-7 breast tumor cells were prevented from proliferating when grown in charcoal-dextran stripped human female serum (CDFHS)-supplemented media (40% and 10%); this inhibition was maximally cancelled by estradiol-17, cisTamoxifen, and Metabolite E, whereas Tamoxifen, N-desmethylTamoxifen and Metabolite Y ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90510-7
更新日期:1985-07-29 00:00:00
abstract::There is an augmented platelet intracellular calcium response to serotonin stimulation in major depression. The role that calcium influx has in this process is not known. The objective of this study was to determine platelet calcium influx in response to serotonin by two methods, Mn2+ influx and 45Ca2+ uptake, in orde...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00608-6
更新日期:2000-01-01 00:00:00
abstract::Transitory immunosupression is reported after intense exercise, especially after an increase in training overload and in overtraining. The influence of intense exercise on plasma hormones and glutamine concentration may contribute to this effect. However, the effect of such exercise-induced changes upon lymphocyte and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.10.015
更新日期:2007-01-16 00:00:00
abstract::The use of xenon as an almost ideal anesthetic with very little side effects is gaining clinical acceptance, yet its effects on the cellular level are still unclear. It affects intracellular Ca2+-homeostasis but up to now no cellular event or Ca2+-signaling system has been described to be specifically sensitive to xen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00320-3
更新日期:1999-01-01 00:00:00
abstract::A review of the rapidly accumulating data in the literature continues to support the notion that catecholamines regulate ovarian function, and extends the complexity of catecholaminergic effects on the ovary via interactions with pituitary and adrenal hormones. It is clear that catecholamines affect growth and differe...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(86)90088-3
更新日期:1986-11-10 00:00:00
abstract::We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90594-s
更新日期:1993-01-01 00:00:00
abstract:AIMS:Fenofibrate is a peroxisome proliferator-associated receptor alpha agonist (PPARα) used clinically for the management of dyslipidemia and is a myocardial fatty acid oxidation stimulator. It has also been shown to have cardiac anti-hypertrophic properties but the effects of fenofibrate on the development of eccentr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.10.022
更新日期:2013-01-17 00:00:00
abstract::Simultaneously drawn arterial and forearm venous levels of free and sulfate conjugated epinephrine and norepinephrine were measured in 8 subjects in order to study the role of skeletal muscle in catecholamine sulfation. A sensitive radioenzymatic assay was used. The average free epinephrine level was 46% lower in veno...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90758-5
更新日期:1982-11-29 00:00:00
abstract::The time course of regional mouse brain distribution of radioactivity after i.v. injection of a tracer dose of [11C]tetrabenazine ([11C]TBZ) has been determined. Radiotracer uptake into brain is rapid, with 3.2% injected dose in the brain at 2 min. Egress from the brain is also very rapid, with only 0.21% of the injec...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90228-h
更新日期:1992-01-01 00:00:00
abstract::Bufalin, which is one of prominent components of Chinese toad venom, was found to decrease the rate of cell proliferation of mouse melanoma clone B16-F10 cells and a concomitant stimulation of expression of its melanotic phenotype. The effect of bufalin on melanogenesis included stimulation of tyrosinase activity and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90213-9
更新日期:1992-01-01 00:00:00
abstract::Cold acclimation increases the thermogenic capacity of brown adipose tissue (BAT) and this is associated with both a general hypertrophy of the tissue and a selective increase in the proportion of a specific 32,000 molecular weight, GDP-binding protein in the mitochondrial membrane. This protein regulates the activity...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90081-x
更新日期:1984-03-19 00:00:00
abstract::Carbachol (CCH), serotonin (5HT), divalent ionophore A23187, cAMP, and certain neuropeptides, i.e. substance P (SP), inhibit the initial rate of uptake (influx) of 22Na into isolated chicken villus enterocytes. All these agents also increase cytosolic Ca. However, the increases stimulated by CCH, 5HT, and cAMP are not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90506-m
更新日期:1990-01-01 00:00:00
abstract::Glial cells are currently viewed as active partners of neurons in synapse formation. The close proximity of astrocytes to the synaptic cleft implicates that they strongly influence synapse function as well as suggests that these cells might be potential targets for neuronal-released molecules. In this review, we discu...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2011.04.005
更新日期:2011-10-10 00:00:00
abstract::An experimental model which resembles human drug addiction was developed to study the effect of chronic drug (cocaine or morphine) administration on the immune system. As malnutrition has been associated with drug use, a low protein diet has been evaluated for its contribution to the impairment of the immune system du...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90138-2
更新日期:1991-01-01 00:00:00
abstract::Immunization with plasmid DNA encoding antigenic proteins elicits both antibody and cell-mediated immune responses. This method of producing the protein antigens of interest directly in host cells can provide appropriate tertiary structure for the induction of conformationally specific antibodies, and also facilitates...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(96)00502-4
更新日期:1997-01-01 00:00:00
abstract::The mechanism of the antithrombotic effects of heparin and the synthetic antithrombin agent argatroban was evaluated in a dog model. Thrombus formation following balloon injury was evaluated by angioscopy in the right iliac arteries of 20 dogs to serve as a control. After the evaluation of the growth of thrombus on th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.10.084
更新日期:2005-10-07 00:00:00
abstract::More than half of ADAM (a disintegrin and metalloprotease) family members are expressed in mammalian male reproductive organs such as testis and epididymis. The ADAM19 gene identified in mouse is a member of the ADAM family and is highly enriched in testes of a newborn mouse. The present study was performed to determi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.07.002
更新日期:2006-10-26 00:00:00