Radioenzymatic analysis of neurotransmitters.

abstract：:The mouse neuroblastoma x rat glioma hybrid NG108-15 was previously shown to express delta opioid receptors. Because neuroblastoma cells display different phenotypes and cloned cell lines are heterogenous, we studied the characteristics and distribution of human 125I-beta-endorphin (125I-beta E) binding sites in cultu...

journal_title：Life sciences

authors： Cone RI,Rosenfeld S,Lameh J,Sadée W

更新日期：1992-01-01 00:00:00

abstract：:Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that peripar...

journal_title：Life sciences

authors： Kristal MB,Thompson AC,Abbott P,Di Pirro JM,Ferguson EJ,Doerr JC

更新日期：1990-01-01 00:00:00

abstract：AIM:Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated. MATERIALS AND METHODS:Th...

journal_title：Life sciences

authors： Abareshi A,Hosseini M,Beheshti F,Norouzi F,Khazaei M,Sadeghnia HR,Boskabady MH,Shafei MN,Anaeigoudari A

更新日期：2016-12-15 00:00:00

abstract：:The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...

journal_title：Life sciences

authors： Barritt D,Yamamura HI,Roeske WR

更新日期：1982-03-08 00:00:00

abstract：:We have previously reported that metronidazole treatment increases human lymphocyte proliferation showing individual differences. This drug and its metabolites are imidazole compounds like histamine and cimetidine. The first is an endogenous amine that inhibits T-helper lymphocyte proliferation, and the second is a hi...

journal_title：Life sciences

authors： Elizondo G,Ostrosky-Wegman P

更新日期：1996-01-01 00:00:00

abstract：:Increased levels of particulate matter (PM) air pollutants in East Asia have resulted in detrimental health impacts increasing morbidity and mortality. Epidemiological studies suggest a possible relation between the cutaneous exposure of PM and increased oxidative stress and inflammation which lead to skin lesions. Th...

journal_title：Life sciences

authors： Fernando IPS,Jayawardena TU,Kim HS,Vaas APJP,De Silva HIC,Nanayakkara CM,Abeytunga DTU,Lee W,Ahn G,Lee DS,Yeo IK,Jeon YJ

更新日期：2019-09-15 00:00:00

abstract：:Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial DNA (mtDNA), altering inflammatory mediators, and neurodegener...

journal_title：Life sciences

authors： Pal S,Rao GN,Pal A

更新日期：2020-09-01 00:00:00

abstract：AIM:Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildaglip...

journal_title：Life sciences

authors： Nath M,Bhattacharjee K,Choudhury Y

更新日期：2021-02-01 00:00:00

abstract：AIMS:Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still undefined. Lesional apoptotic cells and necrotic core forma...

journal_title：Life sciences

authors： Cong G,Yan R,Huang H,Wang K,Yan N,Jin P,Zhang N,Hou J,Chen D,Jia S

更新日期：2017-03-15 00:00:00

abstract：:Fluorescence spectroscopy was used to examine the biophysical characteristics of human platelet membranes as a function of subject age. The structural order of membrane lipid domains was determined with the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), a fluorescent probe that preferentially localizes in the hydrocarbon...

journal_title：Life sciences

authors： Cohen BM,Zubenko GS

更新日期：1985-10-14 00:00:00

abstract：:A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyr...

journal_title：Life sciences

authors： Subarnas A,Tadano T,Nakahata N,Arai Y,Kinemuchi H,Oshima Y,Kisara K,Ohizumi Y

更新日期：1993-01-01 00:00:00

abstract：:The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...

journal_title：Life sciences

authors： Sugio K,Daly JW

更新日期：1983-07-04 00:00:00

abstract：:Nicotine is the main constituent of tobacco smoke responsible for the elevated risk of the cardiovascular disease and sudden coronary death associated with smoking, presumably by provoking cardiac arrhythmias. The cellular mechanisms may be related to the ability of nicotine to prolong action potentials and to depolar...

journal_title：Life sciences

authors： Wang H,Shi H,Wang Z

更新日期：1999-01-01 00:00:00

abstract：:Hypotensive responses to tryptophan and 5-hydroxytryptophan infusions were studied in normotensive male Sprague-Dawley rats. Results showed that 5-hydroxytryptophan but not tryptophan lowered pressure in a dose dependent way in direct relation to the production of brain serotonin and 5-HIAA. Intrinsic release of serot...

journal_title：Life sciences

authors： Freed CR,Echizen H,Bhaskaran D

更新日期：1985-11-11 00:00:00

abstract：:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten. We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone. However, since the structure of naloxone allows it...

journal_title：Life sciences

authors： Fanciulli G,Dettori A,Demontis MP,Tomasi PA,Anania V,Delitala G

更新日期：2005-02-25 00:00:00

abstract：:Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME), deteriorate insulin sensitivity and lipid metabolism, while the addition of L-arginine reverses this deterioration. L-arginine is a precurso...

journal_title：Life sciences

authors： Kawano T,Nomura M,Nisikado A,Nakaya Y,Ito S

更新日期：2003-10-24 00:00:00

abstract：:Effects of hexamethonium (C6) on the excitability of sympathetic ganglion cells were examined by means of intracellular recording. When DC currents were injected, high concentrations of C6 significantly augmented the repetitive firing of the cells without any change in threshold voltage for initiation of the spike. Th...

journal_title：Life sciences

authors： Kawai T,Oka J,Watanabe M

更新日期：1985-06-17 00:00:00

abstract：:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...

journal_title：Life sciences

authors： Bhattacharya D,Majrashi M,Ramesh S,Govindarajulu M,Bloemer J,Fujihashi A,Crump BR,Hightower H,Bhattacharya S,Moore T,Suppiramaniam V,Dhanasekaran M

更新日期：2018-02-01 00:00:00

abstract：:Sensitivity of brain muscarinic acetylcholine receptors to the agonists was examined in nicotine tolerant animals which were developed by acutely repeated injections of nicotine. In conscious rats, the dose-response curves of muscarinic agonists arecoline and pilocarpine, cholinesterase inhibitors soman and physostigm...

journal_title：Life sciences

authors： Wang H,Cui WY,Liu CG

更新日期：1996-01-01 00:00:00

abstract：:Vascular inflammation induced by the proinflammatory cytokine/NF-kappaB pathway is one of the key mechanisms in the development of atherosclerosis. Peroxisome proliferators-activated receptor-gamma (PPARgamma) plays an important role in the prevention of arterial inflammation and formation of atherogenesis. Herein we ...

journal_title：Life sciences

authors： Park KG,Lee KM,Chang YC,Magae J,Ando K,Kim KB,Kim YN,Kim HS,Park JY,Lee KU,Lee IK

更新日期：2006-12-14 00:00:00

abstract：:The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...

journal_title：Life sciences

authors： Yocca FD,Eison AS,Hyslop DK,Ryan E,Taylor DP,Gianutsos G

更新日期：1991-01-01 00:00:00

abstract：:The effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole (PQQ-glycine adduct) on DNA synthesis were examined using cultured human fibroblasts. Confluent fibroblasts were cultured in serum-free Dulbecco's modified Eagle's media, and various concentrations of PQQ and PQQ-oxazole were added to the media. After incub...

journal_title：Life sciences

authors： Naito Y,Kumazawa T,Kino I,Suzuki O

更新日期：1993-01-01 00:00:00

abstract：:Testosterone propionate, cortisone, or sesame oil vehicle were given to rats during the last week of pregnancy so that effects of the hormones on anogenital distance, breeding capacity and vaginal opening of the female progeny could be contrasted. Testosterone significantly increased anogenital distance and delayed va...

journal_title：Life sciences

authors： McCoy SJ,Shirley BA

更新日期：1992-01-01 00:00:00

abstract：:Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...

journal_title：Life sciences

authors： Zbuzek VK,Cohen B,Wu W

更新日期：1997-01-01 00:00:00

abstract：AIMS:Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been reported to be a novel marker for the progression of chronic kidney disease (CKD). We have recently found that accumulation of ADMA could trigger peritubular capillary loss, thus contributing to tubulointerstitial ischemia ...

journal_title：Life sciences

authors： Ueda S,Yamagishi S,Matsumoto Y,Kaida Y,Fujimi-Hayashida A,Koike K,Tanaka H,Fukami K,Okuda S

更新日期：2009-06-05 00:00:00

abstract：:NMDA receptors are glutamate-regulated ion channels of critical importance for many neurophysiological and neuropathological processes. Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential. We have investigated the effect of NMDA and the required...

journal_title：Life sciences

authors： Liu Y,Hill RH,Arhem P,von Euler G

更新日期：2001-03-09 00:00:00

abstract：:Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal cancer, with a predicted 145,600 new cases to be diagnosed in 2019. Curcuminoids and its synthetic analogs are now of interest due to their bioactive attribute...

journal_title：Life sciences

authors： Selvam C,Prabu SL,Jordan BC,Purushothaman Y,Umamaheswari A,Hosseini Zare MS,Thilagavathi R

更新日期：2019-12-15 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:Autophagy is an essential cellular mechanism which plays "housekeeping" role in normal physiological processes including removing of long lived, aggregated and misfolded proteins, clearing damaged organelles, growth regulation and aging. Autophagy is also involved in a variety of biological functions like development,...

journal_title：Life sciences

authors： Ravanan P,Srikumar IF,Talwar P

更新日期：2017-11-01 00:00:00

abstract：:Tissue-type plasminogen activator (tPA) is a key enzyme in the fibrinolysis system and the regulation of its expression has been extensively studied in cultured vascular endothelial cells. Many kinds of supplements including growth factors are needed, however, to keep endothelial cells viable, which leads the culture ...

journal_title：Life sciences

authors： Yoshino A,Suzuki K,Urano T,Aoki K,Takada Y,Kazui T,Takada A

更新日期：2002-02-08 00:00:00