Brain serotonin and blood pressure regulation: studies using in vivo electrochemistry and direct tissue assay.

Abstract:

:Hypotensive responses to tryptophan and 5-hydroxytryptophan infusions were studied in normotensive male Sprague-Dawley rats. Results showed that 5-hydroxytryptophan but not tryptophan lowered pressure in a dose dependent way in direct relation to the production of brain serotonin and 5-HIAA. Intrinsic release of serotonin from brain was also studied during periods of induced hypertension and hypotension. Brain monoamine responses to blood pressure changes induced by intravenous phenylephrine and nitroprusside were measured in dorsal raphe nucleus and nucleus tractus solitarius by in vivo electrochemistry. Results showed that 5-HIAA was increased during drug induced hypertension and during reflex hypertension which followed a period of hypotension. These changes were blocked by sinoaortic denervation indicating that these central serotonergic neurons are responding to increased pressure sensed by baroreceptors. Therefore, serotonin has a role in blood pressure regulation as a pharmacologic agent and as a neurotransmitter in homeostatic control of pressure.

journal_name

Life Sci

journal_title

Life sciences

authors

Freed CR,Echizen H,Bhaskaran D

doi

10.1016/0024-3205(85)90220-6

subject

Has Abstract

pub_date

1985-11-11 00:00:00

pages

1783-93

issue

19

eissn

0024-3205

issn

1879-0631

pii

0024-3205(85)90220-6

journal_volume

37

pub_type

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