Prolidase and prolidase deficiency.

abstract：:Increased ventricular ANF-mRNA is observed as a compensating mechanism in response to many forms of overload including chronic exercise. It is unknown if exercise-induced increases in ANF expression are mediated at the transcriptional level and whether specific cis-element(s) may be involved. To study this, rats were ...

journal_title：Life sciences

authors： Edwards JG

更新日期：2002-04-26 00:00:00

abstract：:Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, was administered orally for 12 weeks to male rats with prednisolone-induced osteoporosis. Microdensitometric analysis of a roentgenograph of the femurs revealed that ipriflavone increased the density of the distal metaphysis dose-dependently and tended to incre...

journal_title：Life sciences

authors： Yamazaki I,Shino A,Shimizu Y,Tsukuda R,Shirakawa Y,Kinoshita M

更新日期：1986-03-10 00:00:00

abstract：:Novel magnetic resonance imaging sequences have and still continue to play an increasing role in neuroimaging and neuroscience. Among these techniques, diffusion-weighted imaging (DWI) has revolutionized the diagnosis and management of diseases such as stroke, neoplastic disease and inflammation. However, the effects ...

journal_title：Life sciences

authors： Rau PR,Sellner J,Heiland S,Plaschke K,Schellinger PD,Meyding-Lamadé UK,Lamadé WR

更新日期：2006-02-09 00:00:00

abstract：:The bradykinin-induced sensitization of cutaneous nociceptors to heat was previously shown to be abolished by cyclooxygenase blockade suggesting that endogenous prostaglandins exerted a heat-sensitizing action. The present study aimed at investigating the effects of exogenous prostaglandin E(2) (PGE(2)) and I(2) (PGI(...

journal_title：Life sciences

authors： Derow A,Izydorczyk I,Kuhn A,Reeh PW,Petho G

更新日期：2007-12-14 00:00:00

abstract：:The present study investigates the effect of a pituitary hormone (LH) and a thymic factor (Thymosin Fraction 5 = TF5) on in vitro and in vivo spleen cell proliferative response of 2, 6 and 8-month-old Balb/c mice. In vitro experiments showed that the addition of LH at various concentrations (0.5, 5, 50 or 500 ng/ml) t...

journal_title：Life sciences

authors： Rouabhia M,Ghanmi Z,Chakir J,Othmane O,Deschaux P

更新日期：1990-01-01 00:00:00

abstract：:The role of Na+ and Ca2+ channels in glutamate-mediated hypoxic injury was investigated in slices of the rat cerebral cortex. Hypoxic injury was determined by mitochondrial reduction of 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyltetrazolium bromide after exposure of brain slices to 30-min of hypoxia/glucose deprivation fo...

journal_title：Life sciences

authors： Oka M,Itoh Y,Ukai Y

更新日期：2000-09-29 00:00:00

abstract：:Ozone is a highly efficient disinfectant which may have significant advantages in water treatment compared to chlorine. It has, however, been shown that mutagenic and possibly carcinogenic byproducts may be produced under certain conditions of ozonation. Light chlorination following ozonization may meet the highest st...

journal_title：Life sciences

authors： Carmichael NG,Winder C,Borges SH,Backhouse BL,Lewis PD

更新日期：1982-01-11 00:00:00

abstract：:Phenylephrine effect on liver and kidney cortex mitochondrial pyruvate concentration was investigated. While in liver the alpha 1-adrenergic agent produced a decrease in pyruvate content, a significant increase was observed in kidney, even in the presence of 0.5 mM alpha-cyano-4-hydroxy-cinnamate. These changes were n...

journal_title：Life sciences

authors： Oliver J,Sola MM,Salto R,Vargas AM

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bioaccumulate in adipose tissue, disturbing its metabolism and the balance of adipokines, related to obesity. The altering secretion pattern of adipokines from the adipose tissue and the increasing mechanical load in weight-bearing joint...

journal_title：Life sciences

authors： Abella V,Pérez T,Scotece M,Conde J,Pirozzi C,Pino J,Lago F,González-Gay MÁ,Mera A,Gómez R,Gualillo O

更新日期：2016-07-15 00:00:00

abstract：:Mammalian NADPH-ferredoxin reductase (EC 1.18.1.2) functions in the mitochondrial electron transport chain for cytochrome P-450-dependent steroid hydroxylation. Significant homology of three-dimensional structure exists in the surroundings of FAD between NADPH-ferredoxin reductase and NADH-cytochrome b5 reductase. The...

journal_title：Life sciences

authors： Jiang HB,Ichikawa M,Furukawa A,Tomita S,Ohnishi T,Ichikawa Y

更新日期：2001-02-23 00:00:00

abstract：:Ovine fetal renal responses to ANF decrease during the last third of gestation, although circulating fetal plasma atrial natriuretic factor (ANF) levels are higher than in the maternal circulation, and do not change with gestation. This study examined whether previously reported maturational changes in fetal renal res...

journal_title：Life sciences

authors： Dodd A,Kullama LK,Ervin MG,Leake RD,Ross MG

更新日期：1994-01-01 00:00:00

abstract：:Peptide Histidine Isoleucine (PHI) is generally considered a low affinity agonist for Vasoactive Intestinal Peptide (VIP) receptors. In this study, we investigated the presence and characteristics of [125I]PHI binding sites on rat liver membranes. Detergents at nonsolubilizing concentrations (1 mM CHAPS or 0.01% Tween...

journal_title：Life sciences

authors： Paul S,Chou J,Kubota E

更新日期：1987-11-23 00:00:00

abstract：AIMS:High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, the first place of nutrients access, remains unknown. Our aim was to evaluate the intestinal morphology and nutrients transporters content in mice fed standard (LFD) or high f...

journal_title：Life sciences

authors： Losacco MC,de Almeida CFT,Hijo AHT,Bargi-Souza P,Gama P,Nunes MT,Goulart-Silva F

更新日期：2018-06-01 00:00:00

abstract：:Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...

journal_title：Life sciences

authors： Adams A,Jarrott B

更新日期：1982-03-15 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo pr...

journal_title：Life sciences

authors： Molchan SE,Hill JL,Minichiello M,Vitiello B,Sunderland T

更新日期：1994-01-01 00:00:00

abstract：:Changes in the activities of protein kinase A (cAMP-dependent), protein kinase C (Ca2+/phospholipid-dependent), and protein kinase M (Ca2+/calmodulin-dependent) in dog heart and liver were studied 4 hr following endotoxin injection. Protein kinases A and C were extracted and partially purified by DEAE-cellulose chroma...

journal_title：Life sciences

authors： Hsu HK,Tao YP,Chen XY,Huang J,Liu MS

更新日期：1994-01-01 00:00:00

abstract：AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...

journal_title：Life sciences

authors： Cui F,Guan Y,Guo J,Tian YM,Hu HF,Zhang XJ,Zhang Y

更新日期：2018-07-15 00:00:00

abstract：AIMS:With the purpose of exploring combinatorial options that could enhance the bactericide efficacy of linezolid against Gram-negative bacteria, we assessed the extent of combination of nano-silver and linezolid. MAIN METHODS:In this study, we selected Escherichia coli MTCC 443 as a model to study the combinatorial e...

journal_title：Life sciences

authors： Anuj SA,Gajera HP,Hirpara DG,Golakiya BA

更新日期：2019-08-01 00:00:00

abstract：AIMS:Sarcopenia is characterized by muscle mass and strength loss and reduced physical activity. Branched-chain amino acids (BCAAs) were recently described as an activator of protein synthesis via mammalian target of rapamycin (mTOR) signaling for muscle atrophy. In cardiovascular diseases, excessive activation of the ...

journal_title：Life sciences

authors： Yamanashi K,Kinugawa S,Fukushima A,Kakutani N,Takada S,Obata Y,Nakano I,Yokota T,Kitaura Y,Shimomura Y,Anzai T

更新日期：2020-06-01 00:00:00

abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

journal_title：Life sciences

authors： Turner J,Hughes LF,Toth LA

更新日期：2010-01-30 00:00:00

abstract：:Leukocyte interactions with endothelial cell monolayers (ECM) and smooth muscle cells (SMC) play an important role during inflammatory processes. Several studies describe an inhibitory effect of dexamethasone on polymorphonuclear leukocytes (PMNL), endothelial cell function, and interleukin-1 (IL-1) release. Aim of th...

journal_title：Life sciences

authors： Hofbauer R,Gmeiner B,Handler S,Speiser W,Kapiotis S,Frass M

更新日期：1999-01-01 00:00:00

abstract：:Polyamines (spermidine, spermine and putrescine) inhibited the adenylate cyclase activity in a concentration dependent manner in human erythrocyte plasma membranes. Spermidine (Spd) exhibited more inhibitory effect than spermine (Spm) and putrescine (Put). On the contrary, the addition of amino acids (arginine, glutam...

journal_title：Life sciences

authors： Khan NA,Quemener V,Moulinoux P

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...

journal_title：Life sciences

authors： Liu J,Xu Y,Wu Q,Ding Q,Fan W

更新日期：2018-11-01 00:00:00

abstract：:Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...

journal_title：Life sciences

authors： Tu CC,Wan BY,Zeng Y

更新日期：2020-04-15 00:00:00

abstract：:Effects of lithium (Li) deficiency and/or immobilization stress on the thymus weight and differential blood count of rats were studied. The thymus weight of the rats fed a low Li diet were lighter than those of rats fed a Li supplemented diet, whether the rats were exposed to stress or not. Of the rats not exposed to ...

journal_title：Life sciences

authors： Ono T,Iijima M,Shinoda S,Wada O

更新日期：1997-01-01 00:00:00

abstract：:The effect of oral administration of Clostridium butyricum Miyairi on the formation and dissolution of gallstones was examined in a mouse model of cholesterol cholelithiasis, in comparison with that of chenodeoxycholic acid (CDCA). A diet containing cholesterol and sodium cholate was used as a lithogenic diet. The fee...

journal_title：Life sciences

authors： Takeda Y,Itoh H,Kobashi K

更新日期：1983-01-31 00:00:00

abstract：AIMS:Recent evidence has shown that systemic administration of sulfonylureas and biguanides block the diclofenac-induced antinociception, but not the effect produced by indomethacin. However, there are no reports about the peripheral interaction between analgesics and the biguanides metformin and phenformin. Therefore,...

journal_title：Life sciences

authors： Ortiz MI

更新日期：2012-01-02 00:00:00

abstract：OBJECTIVE:We aimed to explore the expression level and biological function of miR-145-5p in preeclampsia (PE). METHODS:The differentially expressed miRNA/mRNA between normal placentas and PE placentas were screened using the GSE84260 and GSE73374 datasets from the Gene Expression Omnibus Database. The expression of mi...

journal_title：Life sciences

authors： Lv Y,Lu X,Li C,Fan Y,Ji X,Long W,Meng L,Wu L,Wang L,Lv M,Ding H

更新日期：2019-12-15 00:00:00

abstract：:The initial stage of atherosclerotic plaque formation involves oxidation of the phosphatidyl-choline moiety of low density lipoprotein (LDL) and subsequent uptake by macrophages. Ongoing uptake in developing plaque also may involve oxidized LDL and would require an oxidizing environment in plaque lipids. Atherosclerot...

journal_title：Life sciences

authors： Piotrowski JJ,Shah S,Alexander JJ

更新日期：1996-01-01 00:00:00

abstract：:Inflammation, inflammatory mediators, cyclooxygenase (COX)-2, and inducible nitric oxide (iNOS) are all influenced by age-related oxidative status. To investigate the effect of dietary fish oil (FO) and calorie restriction (CR) on oxidative stress-related inflammatory status with age, (NZB/NZW) F1 (B/W) mice were fed ...

journal_title：Life sciences

authors： Kim YJ,Kim HJ,No JK,Chung HY,Fernandes G

更新日期：2006-04-18 00:00:00