Lithium deficiency reduces thymus weight and alters differential blood count in rats.

abstract：:Autophagy is a metabolic process that maintains the homeostasis of the intracellular environment by degrading damaged proteins and organelles in lysosomes. Recently, independent studies have indicated that some hepatitis viruses develop abilities to hijack autophagy for their replication, such as hepatitis B (HBV) and...

journal_title：Life sciences

authors： Zhang L

更新日期：2020-02-01 00:00:00

abstract：AIMS:To examine the role of trypsin in the immune response of macrophages and to determine whether protease-activated receptors (PARs) are involved in the effects of trypsin. MAIN METHODS:We used RAW264.7 cells and peritoneal macrophages isolated from C57BL/6 wild-type mice, PAR2 knockout mice, and ddY mice. Macrophag...

journal_title：Life sciences

authors： Komatsu H,Shimose A,Shimizu T,Mukai Y,Kobayashi J,Ohama T,Sato K

更新日期：2012-08-21 00:00:00

abstract：:It has been previously shown that treatment of newborn rats with the polyamines putrescine, spermidine and spermine can rescue sympathetic neurons from naturally occurring cell death and from induced death after axotomy or immunosympathectomy. The present study demonstrates that polyamine treatment can also prevent th...

journal_title：Life sciences

authors： Gilad GM,Gilad VH

更新日期：1989-01-01 00:00:00

abstract：HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...

journal_title：Life sciences

authors： Yue J,Zhu T,Yang J,Si Y,Xu X,Fang Y,Fu W

更新日期：2020-07-15 00:00:00

abstract：:Pulmonary fibrosis (PF), which is characterized by excessive matrix formation, may ultimately lead to irreversible lung damage and thus death. Fibroblast activation has been regarded as a central event during PF pathogenesis. In our previous study, we confirmed that the miR-627/high-mobility group box protein 1 (HMGB1...

journal_title：Life sciences

authors： Li J,Zhang X,Wang T,Li J,Su Q,Zhong C,Chen Z,Liang Y

更新日期：2021-01-20 00:00:00

abstract：:The potency of six antimuscarinic oxotremorine analogs at sympathetic ganglionic M1 and brainstem M2 muscarinic receptors was compared in the rat. Inhibition of the pressor effects of McNA343 or physostigmine was used as functional indicators of M1 and M2 blockade, respectively. 50% inhibitory doses (ID50) were calcul...

journal_title：Life sciences

authors： Vargas HM,Ringdahl B

更新日期：1990-01-01 00:00:00

abstract：:Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced ...

journal_title：Life sciences

authors： Sakuma Y,Hagihara H,Nagayoshi A,Ohne K,Mutoh S,Ito Y,Nakahara K,Notsu Y,Okuhara M

更新日期：1997-01-01 00:00:00

abstract：:The tumor promoter okadaic acid (OKA), is a marine toxin of algal origin, identified as a potent inhibitor of protein phosphatases 1 and 2A, and possibly enhancing calcium influx through voltage dependent calcium channels (VSSC). We now report that OKA at concentrations as low as 0.5 nM produced neurotoxicity, charact...

journal_title：Life sciences

authors： Fernández MT,Zitko V,Gascón S,Novelli A

更新日期：1991-01-01 00:00:00

abstract：:The binding characteristics of the sigma-1 selective benzomorphan [3H]-(+)-pentazocine were determined in human cerebellar membranes. Saturation binding analysis revealed two affinity sites with a KDH of 1.4 +/- 0.7 nM and a KDL of 33.6 +/- 11.9 nM. Kinetic studies performed at 25 degrees C demonstrated reversible bin...

journal_title：Life sciences

authors： Zabetian CP,Staley JK,Flynn DD,Mash DC

更新日期：1994-01-01 00:00:00

abstract：:The purpose of the this study was to characterize the putative anxiolytic-like effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before beh...

journal_title：Life sciences

authors： Kim WK,Jung JW,Ahn NY,Oh HR,Lee BK,Oh JK,Cheong JH,Chun HS,Ryu JH

更新日期：2004-10-22 00:00:00

abstract：:Atherosclerosis (AS) is a chronic inflammatory disease that results from Oxidized low-density lipoprotein (Ox-LDL) induced endothelial dysfunction. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is closely related to the development of epithelial cells, but the role of CPEB1 in AS remains unknown. The R...

journal_title：Life sciences

authors： Xu K,Xiwen Liu,Ren G,Yin D,Guo S,Zhao Y

更新日期：2019-12-15 00:00:00

abstract：:The hypocholesterolemic effect of taurine was examined in mice fed a high-cholesterol diet containing 1% cholesterol and 0.25% sodium cholate. Male C57BL/6 mice were divided into 3 groups: control group (HC), 1% taurine-supplemented group (HCT+), and taurine-deficient group (HCT-) produced by supplying 0.5% guanidinoe...

journal_title：Life sciences

authors： Chen W,Matuda K,Nishimura N,Yokogoshi H

更新日期：2004-02-27 00:00:00

abstract：AIM:Beta asarone is the major constituent of oil obtained from Acorus calamus, the Indian traditional medicine plant. Several studies have shown that beta asarone causes liver and cardiac damages but the reproductive toxicity is not well understood. The present study was initiated to investigate whether beta asarone ha...

journal_title：Life sciences

authors： Benny B,George Priya Doss C,Thirumal Kumar D,Asha Devi S

更新日期：2017-03-15 00:00:00

abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...

journal_title：Life sciences

authors： Olgiati V,Quirion R,Bowen WD,Pert CB

更新日期：1982-10-18 00:00:00

abstract：:Phospholipase C (PLC), an enzyme involved in the hydrolysis of membrane phospholipid- phosphatidylinositol-bisphosphate to inositol triphosphate and diacylglycerol, and Phorbol 12, myristate 13, acetate (PMA), a tumor promoting agent, could significantly stimulate testosterone (T) secretion from Leydig cells. Arachido...

journal_title：Life sciences

authors： Didolkar AK,Sundaram K

更新日期：1987-07-27 00:00:00

abstract：:It has been reported that nitric oxide (NO) is involved in the relaxation mechanism of ginsenoside saponin in various smooth muscle in experimental animals. Although ginsenoside Rg(3) showed both endothelium-dependent and -independent component relaxation in vascular smooth muscle, the action mechanism of the relaxati...

journal_title：Life sciences

authors： Kang YJ,Sohn JT,Chang KC

更新日期：2005-05-20 00:00:00

abstract：:We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabeti...

journal_title：Life sciences

authors： Zarzuelo A,Jiménez I,Gámez MJ,Utrilla P,Fernadez I,Torres MI,Osuna I

更新日期：1996-01-01 00:00:00

abstract：:In this paper, we describe the characterization of the expression of monoamine oxidase (MAO) in whole pancreas and in isolated islets of Langerhans from human. Classical monamine oxidase activity assays reveal that both isoforms A & B are present in human pancreas. Two complementary approaches indicated that both MAO ...

journal_title：Life sciences

authors： Pizzinat N,Chan SL,Remaury A,Morgan NG,Parini A

更新日期：1999-01-01 00:00:00

abstract：:The modulation of Ca2+ release by synthetic bee venom melittin was examined in equine and human terminal cisternae-containing fractions. Melittin (0.1 microM) decreased the threshold of Ca(2+)-induced Ca2+ release by 20% in equine muscle and by 36% in human muscle. If terminal cisternae fractions were first preloaded ...

journal_title：Life sciences

authors： Fletcher JE,Tripolitis L,Beech J

更新日期：1992-01-01 00:00:00

abstract：:Alpha adrenergic receptors are identified on basolateral plasma membranes derived from proximal tubular epithelial cells. The density of alpha 2 receptors was over two-fold greater than alpha 1 receptors. The basolateral membranes were devoid of beta receptors. These results support previous demonstrations of alpha ad...

journal_title：Life sciences

authors： Jensen RE,Berndt WO

更新日期：1988-01-01 00:00:00

abstract：:Kainic acid (KA) is a potent convulsant which, when administered subcutaneously, induces sustained limbic seizures and a pattern of limbic brain damage that is thought to be seizure-mediated. Diazepam suppresses and morphine enhances both the seizures and brain damage induced by KA. Here we show that morphine enhancem...

journal_title：Life sciences

authors： Fuller TA,Olney JW,Conboy VT

更新日期：1982-07-19 00:00:00

abstract：:Amyloid beta protein (Abeta) alters signal transduction systems, including increases in the cytosolic free calcium ([Ca2+]i) response which have pathophysiological significance in Alzheimer's disease (AD). The purposes of this study were to elucidate the mechanism involved in Abeta's effect on the Ca2+ signal and to e...

journal_title：Life sciences

authors： Huang HM,Ou HC,Hsieh SJ,Chiang LY

更新日期：2000-01-01 00:00:00

abstract：:Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and synovial tissues from patients with rheumatoid arthritis (RA). To investigate the role of IL-18 in rheumatoid synovitis, the levels of IL-18 and serum amyloid A (SAA) were measured in synovial fluids from 24 patie...

journal_title：Life sciences

authors： Tanaka F,Migita K,Kawabe Y,Aoyagi T,Ida H,Kawakami A,Eguchi K

更新日期：2004-02-13 00:00:00

abstract：:Using a two-lever drug discrimination procedure, six rats were trained to discriminate 0.5 mg/kg of racemic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) from saline. Once trained, the animals demonstrated a dose-related decrease in discriminative performance upon administration of lower doses of DOI (ED50 = 0.1...

journal_title：Life sciences

authors： Glennon RA

更新日期：1986-09-01 00:00:00

abstract：:Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...

journal_title：Life sciences

authors： Berrettini WH,Nurnberger JI Jr,Gold PW,Chretien M,Chrousos GP,Chan JS,Goldin LR,Gershon ES

更新日期：1985-09-30 00:00:00

abstract：AIMS:Oxidative stress has been largely implicated in the pathogenesis of anoxia/reoxygenation injury. Ganoderma atrum polysaccharide (PSG-1), the most abundant component extracted from the fruiting bodies of G. atrum, has been shown to possess potent antioxidant activity. In this study, we investigated whether PSG-1 at...

journal_title：Life sciences

authors： Li WJ,Nie SP,Yan Y,Zhu SB,Xie MY

更新日期：2009-10-21 00:00:00

abstract：AIMS:Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring. Because LPS ind...

journal_title：Life sciences

authors： Galvão MC,Chaves-Kirsten GP,Queiroz-Hazarbassanov N,Carvalho VM,Bernardi MM,Kirsten TB

更新日期：2015-01-01 00:00:00

abstract：:Mycobacterium tuberculosis is the most successful pathogen with multiple mechanisms to subvert host immune response, resulting in insidious disease. There are few studies on whether the bacteria undergo antigenic variation in response to host immune pressure. Studies on T cell epitopes of M. tuberculosis can help us f...

journal_title：Life sciences

authors： Jiang Y,Liu H,Dou X,Zhao X,Li M,Li G,Bai Y,Zhang W,Lian L,Yu Q,Zhang J,Wan K

更新日期：2018-09-15 00:00:00

abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

journal_title：Life sciences

authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

更新日期：2004-12-17 00:00:00

abstract：AIMS:The p53 protein, also called guardian of the genome, has a key role in cell cycle regulation. It is activated under stressful circumstances, such as DNA damage which results in permanent arrest or cell death. The protein is disabled in several types of human cancer due to over-expression of the two regulators, Mdm...

journal_title：Life sciences

authors： Golestanian S,Sharifi A,Popowicz GM,Azizian H,Foroumadi A,Szwagierczak A,Holak TA,Amanlou M

更新日期：2016-01-15 00:00:00