Abstract：
:Autophagy is a metabolic process that maintains the homeostasis of the intracellular environment by degrading damaged proteins and organelles in lysosomes. Recently, independent studies have indicated that some hepatitis viruses develop abilities to hijack autophagy for their replication, such as hepatitis B (HBV) and C (HCV); these two viruses are structurally unrelated, but both of them can cause hepatitis, liver cirrhosis, and even hepatocellular carcinoma (HCC). In this review, we will summarize the current knowledge about the mechanism of autophagy induction in HBV- and HCV-infected hepatocytes, discuss how induced autophagy promotes HBV and HCV replication and describe some autophagy-related therapeutic strategies, which may provide perspective with which to cure HBV and HCV infections and their related liver diseases.
journal_name
Life Scijournal_title
Life sciencesauthors
Zhang Ldoi
10.1016/j.lfs.2019.117206subject
Has Abstractpub_date
2020-02-01 00:00:00pages
117206eissn
0024-3205issn
1879-0631pii
S0024-3205(19)31134-8journal_volume
242pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:Although several reports imply that anticoagulants and preservatives contain zinc, the quantity of zinc in heparin, if any, has not been documented. Zinc concentration was determined by flame atomic absorption spectroscopy in varying dilutions of multiple commercially obtained samples of purified sodium heparin N = 15...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90348-x
更新日期：1983-12-26 00:00:00
abstract：:A heterogeneous particulate fraction of mouse brain homogenates binds NRDC 157 (3-phenoxybenzyl [1R, cis]-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate), a potent pyrethroid insecticide, stereospecifically and with high affinity. Stereospecific binding is a minor component of total binding (2.8%); the remai...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90385-5
更新日期：1983-07-18 00:00:00
abstract：:Acute post-ischemic cardiac failure was studied in isolated rat hearts. Xylitol, glutamine, aspartic acid and glycine were added during reperfusion, resulting in no inotropic effect. Concanavalin A had a moderate inotropic effect. When concanavalin A added with xylitol, glutamine, aspartic acid and glycine, a rapid re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90705-8
更新日期：1993-01-01 00:00:00
abstract：:Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90139-0
更新日期：1985-09-30 00:00:00
abstract：:The extract of Crataegus, a mixture of flavonoids and procyanidins extracted from hawthorn, Crataegus oxyacantha, L. and C. monogyna Jacq., relaxed vascular tone or increased production of cyclic GMP in the rat aorta, but flavonoid components of Crataegus extract, hyperoside, rutin and vitexin, did not affect the vasc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00608-1
更新日期：2000-01-01 00:00:00
abstract：:Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2017.12.025
更新日期：2018-02-15 00:00:00
abstract：:Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.047
更新日期：2005-12-12 00:00:00
abstract：AIMS:Mild traumatic brain injury (mTBI) is an important risk factor for cognitive impairment. Despite intense efforts to develop efficient treatments, the current therapies are not often effective and far from satisfactory. Silymarin has been suggested as a therapeutic agent in the treatment of traumatic brain injury. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118049
更新日期：2020-09-15 00:00:00
abstract：:In the early 1970's, some papers appeared reporting an immune response to opiates in animals treated with morphine and in heroin addicts, but further researches failed to confirm these results in humans. The aim of the present work is investigating with a newly developed enzyme immunoassay the existence of specific an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90656-n
更新日期：1993-01-01 00:00:00
abstract：:Myelin basic protein and phosphatidylinositol-4-phosphate are phosphorylated in vitro by ATP and solubilized rat brain myelin. When both substrates are present together, the rate of phosphorylation of each is increased about eight-fold. It appears likely that the phosphate turnover of myelin basic protein and of phosp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90597-6
更新日期：1984-01-16 00:00:00
abstract：:Brief electrical pulses applied to the rat tail elicit a complex vocal response which includes audible (peeps, chatters) and ultrasonic (USV) components. Aspirin and amitriptyline had no effect on the vocal responses. Morphine showed a dose-dependent and naloxone reversible antinociceptive effect on the 1st and 2nd au...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00450-0
更新日期：1998-01-01 00:00:00
abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90594-s
更新日期：1993-01-01 00:00:00
abstract：AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118391
更新日期：2020-10-15 00:00:00
abstract：:We have investigated the possible involvement of arachidonic acid metabolites in dopamine-induced inhibition of adrenocortical steroidogenesis. Administration of dopamine (5 x 10(-5) M) for 20 min to perifused frog adrenal slices caused a marked reduction of the release of both prostaglandin E2 (PGE2) and 6-keto-PGF1 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90292-0
更新日期：1989-01-01 00:00:00
abstract：:11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors have been shown to treat type 2 diabetes (T2D). Since gossypol is an 11β-HSD1 inhibitor, the objective of the present study was to treat T2D and T2D-related liver fibrosis in rat model using low-dose gossypol. T2D was induced by feeding with high fat diet plus i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.044
更新日期：2016-03-15 00:00:00
abstract：:Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients. Carben...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01362-5
更新日期：2001-11-02 00:00:00
abstract：:Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and suli...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.028
更新日期：2006-11-10 00:00:00
abstract：AIMS:Two natural alkaloids, methyl (M) and isopropyl (I) N-methylanthranilates, with recently demonstrated significant pharmacological activities, were assayed for their possible overall effect on intact gastric mucosa and their protective properties towards the onset of gastric lesions induced by diclofenac (a non-ste...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.10.002
更新日期：2013-11-19 00:00:00
abstract：:Recent studies have indicated that Ginsenoside Rb1, one of the major components of ginseng root, may play an important role in protecting cells from damage. Here, we investigated the neuroprotective activity of Rb1 after hypoxic injury in young rats. About 50% animals were dead by exposing hypoxic condition three time...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.011
更新日期：2005-01-14 00:00:00
abstract：:There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00097-1
更新日期：1999-01-01 00:00:00
abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00053-9
更新日期：1995-02-17 00:00:00
abstract：:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90436-u
更新日期：1990-01-01 00:00:00
abstract：:The changes in the energy charge (ATP + 0.5 ADP)/(ATP + ADP + AMP) levels of the remnant liver were studied in relation to changes in the incorporation rate of methyl-3H-thymidine into DNA, the blood ratio of acetoacetate/beta-hydroxybutyrate and indocyanine green (ICG) clearance in 70% hepatectomized rabbits. The ene...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90765-2
更新日期：1982-08-16 00:00:00
abstract：:We proposed that the circadian rhythm of corticosterone in diabetic rats would have a different pattern than that in non-diabetic control rats. To test this hypothesis, 20 male Sprague-Dawley rats were given ad libitum access to a stock diet and housed individually in a light and temperature controlled room. Ten rats ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90536-x
更新日期：1988-01-01 00:00:00
abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.11.011
更新日期：2005-04-01 00:00:00
abstract：AIMS:Osteoblasts and adipocytes originate from common precursor cells. We examined the effects of bone morphogenetic protein-2 (BMP-2) on the molecular mechanisms governing the diametric actions of BMP-2 on simultaneous mature osteoblast and adipocyte differentiation in a clonal mesenchymal progenitor cell line, ROB-C2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.12.011
更新日期：2009-02-27 00:00:00
abstract：:The effects of agents that modulate intracellular release of calcium and protein kinase C (PKC) activation on noradrenaline (NA)-induced contractions of epididymal vas deferens in calcium-free/EGTA (1 mM) medium were investigated. NA (100 microM) or methoxamine (100 microM) evoked repeatable contractions. Clonidine (1...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00231-3
更新日期：1999-01-01 00:00:00
abstract：:Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02106-9
更新日期：2002-10-18 00:00:00
abstract：:Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90210-7
更新日期：1982-10-18 00:00:00
abstract：AIMS:This study sought to determine the impact of in vitro exposure to the herbicide atrazine (ATR) or its major mammalian metabolite diaminochlorotriazine (DACT) on dopaminergic cell differentiation. MAIN METHODS:N27 dopaminergic cells were exposed for 24 or 48 h to ATR or DACT (12-300 μM) and their effects on cell v...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.10.027
更新日期：2013-01-17 00:00:00
