Abstract：
:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki values were between 10(-6) and 10(-3) M. Hill coefficients were about 1. No correlation was found between mAChR inhibiting capacity of these drugs and their activity on alpha adrenergic receptors. In contrast, other transmitters, as dopamine, GABA, glutamic acid, histamine, serotonin, isoproterenol and platelet activating factor (PAF) did not affect the QNB binding.
journal_name
Life Scijournal_title
Life sciencesauthors
Simon G,Filep J,Zelles Tdoi
10.1016/0024-3205(90)90436-usubject
Has Abstractpub_date
1990-01-01 00:00:00pages
2021-5issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(90)90436-Ujournal_volume
47pub_type
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