The effects of noribogaine and harmaline in rats trained with ibogaine as a discriminative stimulus.

abstract：AIM:MicroRNAs (miRNAs) function as oncogenes or tumor suppressors in an extensive variety of human cancers, including prostate cancer (PCa). Herein, the aim of this study is to investigate the effect of miR-381 on autophagy and apoptosis of PCa cells through the reelin (RELN)-mediated the PI3K/AKT/mTOR signaling pathwa...

journal_title：Life sciences

authors： Liao W,Zhang Y

更新日期：2020-08-01 00:00:00

abstract：:Amyloid beta-protein (A beta), the major protein of cerebrovascular and plaque amyloid in Alzheimer disease, is considered a primary factor in the pathology of this disease. The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar ass...

journal_title：Life sciences

authors： Chauhan A,Chauhan VP,Brockerhoff H,Wisniewski HM

更新日期：1991-01-01 00:00:00

abstract：AIM:Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activati...

journal_title：Life sciences

authors： Mazur-Bialy AI

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Quercetin is a major flavonoid in various plants. It possesses the multiple pharmacological actions like vascular integrity and regulatory action of the blood-brain barrier. AIMS:The present study is focused on evaluating the role of solid lipid nanoparticle of quercetin in pentylenetetrazole (PTZ) induced ...

journal_title：Life sciences

authors： Rishitha N,Muthuraman A

更新日期：2018-04-15 00:00:00

abstract：:Sensitivity of brain muscarinic acetylcholine receptors to the agonists was examined in nicotine tolerant animals which were developed by acutely repeated injections of nicotine. In conscious rats, the dose-response curves of muscarinic agonists arecoline and pilocarpine, cholinesterase inhibitors soman and physostigm...

journal_title：Life sciences

authors： Wang H,Cui WY,Liu CG

更新日期：1996-01-01 00:00:00

abstract：:Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...

journal_title：Life sciences

authors： Crowe TP,Greenlee MHW,Kanthasamy AG,Hsu WH

更新日期：2018-02-15 00:00:00

abstract：:Nitric oxide (NO) plays a critical role in the pathogenesis of endotoxin-induced uveitis (EIU). Since NO is a labile free radical, it is difficult to examine the dynamics of NO directly in vivo. In this study, we established a system for direct monitoring of the dynamics of NO and partial pressure of oxygen (pO(2)) in...

journal_title：Life sciences

authors： Yomura Y,Shoji Y,Asai D,Murakami E,Ueno S,Nakashima H

更新日期：2007-03-27 00:00:00

abstract：:The novel guanidines N-(3,4-dimethoxy-2-chlorobenzylideneamino)-guanidine (ME 10092) and N-(3,4-dimethoxy-2-chlorobenzylideneamino)-N1-hydroxyguanidine (PR5) were recently reported to exhibit promising cardioprotective activities in myocardial ischaemia and reperfusion in rats. The current study investigated for the f...

journal_title：Life sciences

authors： Oliver DW,Dormehl IC,Wikberg JE,Louw WK,Dambrova M,van Gelder A,Kilian E,van Rensburg EJ

更新日期：2004-09-10 00:00:00

abstract：:We examined, in young adult women, the association between current low dose oral contraceptive (OC) use and plasma levels of C-reactive protein (CRP), an acute phase reactant predictive of cardiovascular disease risk. We conducted a cross-sectional analysis of 30 healthy, non-smoking, non-obese women (18 OC users and ...

journal_title：Life sciences

authors： Dreon DM,Slavin JL,Phinney SD

更新日期：2003-07-25 00:00:00

abstract：:LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...

journal_title：Life sciences

authors： Tsuchiya M,Inoue K,Matsuda H,Nakamura K,Mizutani T,Miyamoto K,Minegishi T

更新日期：2003-10-17 00:00:00

abstract：PURPOSE:HDAC4/5 and Smad7 are potential therapeutic targets for the onset and progression of B-cell acute lymphocytic leukemia (B-ALL) and indices for clinical prognosis. In contrast, HO-1 (heat shock protein 32) plays a key role in protecting tumor cells from apoptosis. METHODS:HDAC4/5, HO-1 and Smad7 expressions in ...

journal_title：Life sciences

authors： Guo Y,Fang Q,Ma D,Yu K,Cheng B,Tang S,Lu T,Wang W,Wang J

更新日期：2018-08-15 00:00:00

abstract：:The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and CGS 8216, a pyrazoloquinoline, was assessed in two different regions of the rat brain. PK 8165, a compound with reported anxiolytic properties, inhibited [3H]-propyl beta-carboline-3-carboxylate labeled receptors in the...

journal_title：Life sciences

authors： Morelli M,Gee KW,Yamamura HI

更新日期：1982-07-05 00:00:00

abstract：:Even though conventional systemic doses of cimetidine and other histamine H(2) antagonists display minimal brain penetration, central nervous system (CNS) effects (including seizures and analgesia) have been reported after administration of these drugs in animals and man. To test the hypothesis that cimetidine-like dr...

journal_title：Life sciences

authors： Cannon KE,Fleck MW,Hough LB

更新日期：2004-10-08 00:00:00

abstract：:Stability and distribution of orally administered epidermal growth factor (EGF) were examined in newborn and 5-day-old pigs. Forty-five minutes after oral administration of iodine-125 labeled EGF, 60 and 50% of the radioactivity administered were recovered from the internal organs in newborn and 5-day-old pigs, respec...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1998-01-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Regulation of SSAT gene transcription requires the additional interaction of Nr...

journal_title：Life sciences

authors： Stephenson AH,Seidel ER

更新日期：2006-08-22 00:00:00

abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...

journal_title：Life sciences

authors： Olgiati V,Quirion R,Bowen WD,Pert CB

更新日期：1982-10-18 00:00:00

abstract：:The aim of this study was to investigate the effects of cyclosporin (CyA) treatment on biliary glutathione efflux in rats of different ages (1, 2, 4, and 24 months). CyA treatment reduced the liver content of total glutathione in 1-, 2- and 24 month old rats (-30%, -43% and -30%, respectively). By contrast, oxidized g...

journal_title：Life sciences

authors： Palomero J,Galán AI,Muñoz ME,Tuñón MJ,González-Gallego J,Jiménez R

更新日期：2003-11-14 00:00:00

abstract：:NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of exper...

journal_title：Life sciences

authors： Vissers KC,Hoffmann VL,Adriaensen HF,Heylen RJ,Meert TF

更新日期：2005-06-10 00:00:00

abstract：:Studies were performed to compare in vitro and in vivo effects of morphine on the phagocytic function of murine peritoneal macrophages. Macrophage monolayers were incubated with Candida albicans for 30 min in the absence of autologous serum. Morphine added in vitro was found to decrease both the phagocytic activity (p...

journal_title：Life sciences

authors： Rojavin M,Szabo I,Bussiere JL,Rogers TJ,Adler MW,Eisenstein TK

更新日期：1993-01-01 00:00:00

abstract：:Deficiencies in cellular cyclic AMP (cAMP) and nitric oxide (NO) production are thought to be involved in the pathogenesis of diabetic neuropathy. We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific cAMP phosphodiesterase inhibitor, on NO production and Na+, K+-ATPase ...

journal_title：Life sciences

authors： Inada H,Shindo H,Tawata M,Onaya T

更新日期：1999-01-01 00:00:00

abstract：:We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. In the present study the effe...

journal_title：Life sciences

authors： Medvede AE,Abakumova OYu,Podobed OV,Tsvetkova TA,Sandler M,Glover V

更新日期：2001-08-31 00:00:00

abstract：:Because ethanol elicits a dose-dependent hydrolysis of brain sialogangliosides, we tested the possibility that injected gangliosides might antagonize intoxicating doses of ethanol. Clear anti-intoxication effects were seen at 24 hr post-injection of mixed mouse-brain gangliosides at 125-130 mg/kg, but not at lower or ...

journal_title：Life sciences

authors： Klemm WR,Boyles R,Mathew J,Cherian L

更新日期：1988-01-01 00:00:00

abstract：:The kinetics of lymphocyte function associated antigen 1 (LFA-1) expression on spleen cells (SPC) and liver non-parenchymal cells (NPC), and intercellular adhesion molecule 1 (ICAM-1) expression on hepatocytes (HC) was examined in acute liver injury mice induced by a DTH reaction to picryl chloride (PCl). The peak exp...

journal_title：Life sciences

authors： Xu Q,Jiang J,Cao J,Wu F,Fujii H,Saiki I

更新日期：1998-01-01 00:00:00

abstract：:To determine whether rat retinal photoreceptor cells produce inhibin, a molecule closely related to activin, a multifunctional growth factor in the transforming growth factor beta superfamily (TGF beta), we have conducted immunohistochemistry using specific antibodies for inhibin which were raised against a synthetic ...

journal_title：Life sciences

authors： Ying SY,Li SQ,Zhang Z

更新日期：1995-01-01 00:00:00

abstract：:A response in heat shock protein 70 (hsp 70) expression in the beta-naphthoflavone (BNF) treated rainbow trout (Oncorhynchus mykiss) corresponded to altered metabolic status of the liver as evidenced by the lower phosphoenolpyruvate carboxykinase (PEPCK), lactate dehydrogenase and 3-hydroxyacylcoA dehydrogenase activi...

journal_title：Life sciences

authors： Vijayan MM,Pereira C,Forsyth RB,Kennedy CJ,Iwama GK

更新日期：1997-01-01 00:00:00

abstract：:The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely us...

journal_title：Life sciences

authors： Sadeghi S,Soudi S,Shafiee A,Hashemi SM

更新日期：2020-12-01 00:00:00

abstract：:The new Coronavirus (SARS-CoV-2) is the cause of a serious infection in the respiratory tract called COVID-19. Structures of the main protease of SARS-CoV-2 (Mpro), responsible for the replication of the virus, have been solved and quickly made available, thus allowing the design of compounds that could interact with ...

journal_title：Life sciences

authors： Hage-Melim LIDS,Federico LB,de Oliveira NKS,Francisco VCC,Correia LC,de Lima HB,Gomes SQ,Barcelos MP,Francischini IAG,da Silva CHTP

更新日期：2020-09-01 00:00:00

abstract：AIMS:The steroid and xenobiotic receptor (SXR) regulates the transcription of its target genes by interacting with various nuclear receptor cofactors. We have previously shown that silencing mediator for retinoid and thyroid receptors (SMRT) interacts with SXR even in the presence of rifampicin on cytochrome P450 monoo...

journal_title：Life sciences

authors： Hirooka-Masui K,Lesmana R,Iwasaki T,Xu M,Hayasaka K,Haraguchi M,Takeshita A,Shimokawa N,Yamamoto K,Koibuchi N

更新日期：2013-05-20 00:00:00

abstract：:Leucogenenol a heterocyclic enolic thymothyroid hormone (MW 383) whose concentration in the serum regulates the rate at which already committed cells of the bone marrow develop into functional cells, was found to be associated in the thymus with a carrier protein. The carrier protein for leucogenenol is not precipitat...

journal_title：Life sciences

authors： Rice FA,McCurdy JD,Heath JR

更新日期：1984-07-30 00:00:00

abstract：:The potential effect of maternal caffeine ingestion upon total brain protein and the concentration of two prototype neuropeptides, thyrotropin-releasing hormone (TRH) and its derivative, cyclo (His-Pro) in neonates was examined during the nursing period in the context of variable maternal protein intake. Maternal caff...

journal_title：Life sciences

authors： Mori M,Wilber JF,Nakamoto T

更新日期：1983-11-21 00:00:00