Abstract:
:NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of experiments to study the role of spinal NMDA injection on existing cold allodynia, as a measurement of neuropathic pain behavior in rodents. Intrathecal injection of NMDA resulted in an enhanced neuropathic pain behavior in CCI rats on a cold plate. The activity was present from a dose of 5 ng/rat onward and could selectively be reversed by intraperitoneal injections of doses of > or = 0.01 mg/kg MK801. These results support the regulatory role of NMDA receptors in the hypersensitivity to cold observed in neuropathic pain behavior in rodents.
journal_name
Life Scijournal_title
Life sciencesauthors
Vissers KC,Hoffmann VL,Adriaensen HF,Heylen RJ,Meert TFdoi
10.1016/j.lfs.2004.10.068subject
Has Abstractpub_date
2005-06-10 00:00:00pages
414-22issue
4eissn
0024-3205issn
1879-0631pii
S0024-3205(05)00183-9journal_volume
77pub_type
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