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Characterization of the hepatic alpha 1B-adrenoceptors of rats, mice and hamsters.

Abstract：

:The alpha 1-adrenoceptors present in liver membranes from rats, hamsters and mice were characterized using [3H]prazosin. In the liver membranes from the three species a relatively large number of receptors was observed (500-900 fmol/mg of protein) and the affinities for [3H]prazosin were very similar (0.2-0.3 nM). Membrane preincubation with 10 microM chloroethylclonidine markedly decreased [3H]prazosin binding and higher concentrations essentially abolished specific binding of this radioligand. Binding competition experiments indicated the following orders of potency: a) for agonists: oxymetazoline > epinephrine > or = norepinephrine > methoxamine and b) for antagonists: prazosin > WB 4101 > or = phentolamine = benoxathian > 5-methyl urapidil. The affinity for (+)niguldipine was also low but there was variation between the three species. Total RNA obtained from the liver of these species hybridized with the alpha 1B-adrenergic cDNA probe. The data suggest that these receptors correspond to the alpha 1B subtype.

journal_name

Life Sci

journal_title

Life sciences

authors

García-Sáinz JA,Casas-González P,Romero-Avila MT,González-Espinosa C

doi

10.1016/0024-3205(94)90134-1

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

1995-2003

issue

25

eissn

0024-3205

issn

1879-0631

pii

0024-3205(94)90134-1

journal_volume

54

pub_type

杂志文章

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