Abstract:
:Quetiapine, a new atypical antipsychotic drug, has beneficial effects on cognitive impairment and neuropathological changes in treating chronic neurodegenerative diseases. Our previous studies have demonstrated that quetiapine may have neuroprotective properties. In the present study, we investigated the effects of a 2-week pre-administration of quetiapine (10 mg/kg/day, i.p.) on spatial memory impairment and hippocampal neurodegeneration induced by 60-minute bilateral common carotid artery occlusion (CCAO). Following a 7-day recovery phase from CCAO, the spatial memory of the mice was tested using a modified water maze test. After the behavioural test, the mice were sacrificed and brain sections were stained with NeuN (a neuron-specific soluble nuclear antigen), cresyl violet (Nissl), and Fluoro-Jade B. CCAO significantly induced spatial memory impairment and caused neurodegeneration in the hilus of hippocampus, while quetiapine significantly attenuated these changes. This is the first study showing that quetiapine significantly attenuates CCAO-induced spatial memory impairment and this improvement parallels the alleviative effects of quetiapine on CCAO-induced neurodegeneration in the hilus of hippocampus. The results suggest that quetiapine may have defending effects on the impairments induced by cerebral ischemia, which enhances our understanding about the mechanisms of quetiapine.
journal_name
Life Scijournal_title
Life sciencesauthors
Yan B,Bi X,He J,Zhang Y,Thakur S,Xu H,Gendron A,Kong J,Li XMdoi
10.1016/j.lfs.2007.05.020subject
Has Abstractpub_date
2007-07-12 00:00:00pages
353-61issue
5eissn
0024-3205issn
1879-0631pii
S0024-3205(07)00415-8journal_volume
81pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. MAIN METHODS:25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the prima...
journal_title:Life sciences
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.lfs.2020.117962
更新日期:2020-09-01 00:00:00
abstract:AIMS:Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration after partial hepatectomy. While the mechanism of splenectomy promotes liver regeneration by the improvement of the formation of tight junction and the establishment of hepatocyte polarity is still unknown. MA...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.11.032
更新日期:2018-01-01 00:00:00
abstract::A number of studies have been made on the role played by endogenous opioid peptides in the secretion of LH in humans. However no previous studies have compared the effects of the most potent pharmacological agonist and antagonist, morphine and naloxone, in the same subjects. The present study examined the acute effect...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90209-2
更新日期:1986-06-09 00:00:00
abstract::Microvascular changes in the brain are significant causes of cerebral edema and ischemia injury. A number of studies suggest that angiotensin (Ang) II may be involved in the initiation and regulation of processes occurring in brain ischemia. We recently reported that Ang II injures brain microvascular endothelial cell...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.06.049
更新日期:2006-02-16 00:00:00
abstract::Simultaneously drawn arterial and forearm venous levels of free and sulfate conjugated epinephrine and norepinephrine were measured in 8 subjects in order to study the role of skeletal muscle in catecholamine sulfation. A sensitive radioenzymatic assay was used. The average free epinephrine level was 46% lower in veno...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90758-5
更新日期:1982-11-29 00:00:00
abstract::Proteinaceous inhibitors with high inhibitory activities against human neutrophil elastase (HNE) were found in seeds of the Tamarind tree (Tamarindus indica). A serine proteinase inhibitor denoted PG50 was purified using ammonium sulphate and acetone precipitation followed by Sephacryl S-300 and Sephadex G-50 gel filt...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.10.053
更新日期:2005-05-06 00:00:00
abstract::Neurotensin (NT) administered intracerebroventricularly (i.c.v.) to rats, blocks intestinal transit (tested by charcoal meal) in linear relation to the log of the doses within the range of 0.6-2.5 nmoles/rat. NT in this test is about 40 times more active than morphine (M) and 6 times less active than dermorphin (DM) o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90547-7
更新日期:1983-01-01 00:00:00
abstract::The effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue was investigated and compared with other a-adrenergic antagonists. Moxisylyte produced a concentration-dependent relaxation of a norepinephrine-induced (1 x 10(-5) M) contraction of the corpus cavernosum tissue. Pretreatment with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90194-x
更新日期:1989-01-01 00:00:00
abstract::Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(95)00068-2
更新日期:1995-03-03 00:00:00
abstract::Vanilloid spice principles, including capsaicin, stimulate vasoconstriction in the rat hindlimb perfused at constant flow and, depending on dose, either stimulate or inhibit oxygen consumption by this vascular bed. We now present metabolic and functional evidence for two different vanilloid (VN1 and VN2) receptor type...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00250-a
更新日期:1995-01-01 00:00:00
abstract:AIMS:The clinical utilization of the combinations of all-trans-retinoic acid (RA) with antiestrogens, which present synergism of action in breast cancer, has been limited by RA adverse effects, including hepatotoxicity, which may be related with mitochondrial damage. This work evaluated the effects of RA alone and in c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.027
更新日期:2013-07-30 00:00:00
abstract::Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2010.06.001
更新日期:2010-07-17 00:00:00
abstract::Persistent neurochemical changes consistent with parkinsonism have been reported in brains of mice treated with repeated high doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We now report that ethanol or acetaldehyde potentiate MPTP-induced damage to mouse striatum. One hour after the combined treatments...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90030-0
更新日期:1987-03-02 00:00:00
abstract::We recently labeled with carbon-11, a high affinity, selective, 5-HT3 receptor (5-HT3R) ligand, S21007, for potential positron emission tomography (PET) applications. To evaluate the in vivo binding properties of [11C]S21007, its brain regional distribution, tissue and plasma pharmacokinetics and plasma metabolisation...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01058-8
更新日期:1998-01-01 00:00:00
abstract::Single unit recordings were obtained from putative dopaminergic neurons in the substantia nigra of awake, freely moving rats. The cells exhibited waveforms, range of firing rates and types of firing patterns identical to those of identified DA neurons of anesthetized or paralyzed rats. Two firing patterns were observe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90448-5
更新日期:1985-05-20 00:00:00
abstract::The effects of pretreatment with selective mu-, delta- and kappa-opioid receptor antagonists on the enhancement of the pentobarbital-induced loss of the righting reflex by morphine were examined in mice. Mice injected with pentobarbital (50 mg/kg, i.p.) showed an increased duration for the loss of the righting reflex ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(96)00540-1
更新日期:1996-01-01 00:00:00
abstract::Tissue copper levels of brindled (Mobr) mice and normal litter-mates after single and repeated dosing with CuCl2 and/or D-penicillamine are examined, together with a study of the cytosol distribution of copper after CuCl2 treatment. The results confirm that the mutant mouse kidney is capable of extensive copper accumu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90326-5
更新日期:1982-08-02 00:00:00
abstract::Nociceptin/orphanin FQ (=N/OFQ), the endogenous ligand of ORL1 receptor (=NOP), has been reported to induce, in rodents, after intracerebroventricular (i.c.v.) administration, anti-stress and anxiolytic effects. We have observed that the handling of mice followed by an i.c.v. injection of saline, induced a marked incr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02218-x
更新日期:2002-11-29 00:00:00
abstract:AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118749
更新日期:2021-01-15 00:00:00
abstract:AIMS:Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS:Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118521
更新日期:2020-12-01 00:00:00
abstract::The effects of cannabinoid receptor agonists WIN 55,212-2, delta9-tetrahydrocannabinol (delta9-THC), arachidonoylethanolamide (anandamide) and palmitoylethanolamide on lipopolysaccharide (LPS) -induced bronchopulmonary inflammation in mice were investigated. WIN 55,212-2 and delta9-THC induced a concentration-dependen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00324-5
更新日期:1998-01-01 00:00:00
abstract::As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90494-1
更新日期:1985-03-18 00:00:00
abstract::The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or intrathecal (IT) routes. In ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90537-l
更新日期:1991-01-01 00:00:00
abstract::Nitric oxide (NO) is a key mediator in many physiological processes and one of the major receptors through which NO exerts its effects is soluble guanylyl cyclase. Guanylyl cyclase converts GTP to cyclic GMP as part of the cascade that results in physiological processes such as smooth muscle relaxation, neurotransmiss...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02361-5
更新日期:2003-01-17 00:00:00
abstract:AIMS:The aim of the study was to identify key miRNAs related to hepatocellular carcinoma (HCC) and then to explore their potential function and clinical significance. MATERIALS AND METHODS:The miRNA expression profiles of 387 HCC and 62 normal liver tissues were obtained from the Gene Expression Omnibus (GEO) and The ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116596
更新日期:2019-09-01 00:00:00
abstract::A 21 amino acid peptide containing the prepropendothelin sequence from amino acids 110 to 130 and two intrachain disulfide bonds was synthesized and tested for biological activity in the following endothelin assays: 1.) a competition binding assay using [125I]ET-1 and dog heart membranes, 2.) three RIA's using 125I-ET...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90308-e
更新日期:1990-01-01 00:00:00
abstract::Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val, melanin concentrating hormone (MCH), is a cyclic hormone possessing both MCH-like (melanin granule aggregating effect) and melanocyte stimulating hormone (MSH)-like (melanin granule dispersing effect) activities. Nine ring-contracted analogues were s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90460-8
更新日期:1989-01-01 00:00:00
abstract::The concentrations and molecular forms of urinary and plasma gastrin from normal subjects were studied by radioimmunoassays using two region-specific antisera. Urinary concentration of NH2-terminal big gastrin (G-34) immunoreactivity was several hundred times as great as that of COOH-terminal gastrin immunoreactivity....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90112-5
更新日期:1990-01-01 00:00:00
abstract::We have investigated the effect of calcitonin (CT) on adenylate cyclase in membranes from different rat brain areas. Salmon calcitonin (sCT) dose-dependently inhibited the enzyme activity in midbrain, hypothalamus, medulla, pons and caudate nucleus, but was ineffective in adenohypophysis. The inhibitory effect was enh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90404-2
更新日期:1986-12-08 00:00:00
abstract::Clonidine, when administered for prolonged period showed no tolerance to its analgesic activity. Prior exposure to clonidine attenuated the tolerance development to morphine-induced analgesia and the supersensitivity to acetylcholine (ACh) in ileum during chronic morphine treatment. Further, acute administration of lo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90021-8
更新日期:1983-09-19 00:00:00