Abstract：
:We have investigated the effect of calcitonin (CT) on adenylate cyclase in membranes from different rat brain areas. Salmon calcitonin (sCT) dose-dependently inhibited the enzyme activity in midbrain, hypothalamus, medulla, pons and caudate nucleus, but was ineffective in adenohypophysis. The inhibitory effect was enhanced by GTP. Comparison of calcitonins of different origin indicated that sCT was the most potent in inhibiting the enzyme in hypothalamic membranes, eel CT (eCT) was slightly less potent, and human CT (hCT) was ineffective. Chronic I.C.V. pretreatment with sCT did not modify the subsequent in vitro sensitivity of adenylate cyclase to sCT. It is concluded that some of CNS actions of CT might involve modulation of intracellular cAMP levels.
journal_name
Life Scijournal_title
Life sciencesauthors
Nicosia S,Guidobono F,Musanti M,Pecile Adoi
10.1016/0024-3205(86)90404-2subject
Has Abstractpub_date
1986-12-08 00:00:00pages
2253-62issue
23eissn
0024-3205issn
1879-0631pii
0024-3205(86)90404-2journal_volume
39pub_type
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