Inhibitory effects of calcitonin on adenylate cyclase activity in different rat brain areas.

abstract：:A completely randomized controlled study based on a rabbit model was designed to study the effect of repetitive ischemic preconditioning (IPC) on a spinal cord ischemic reperfusion injury. Twenty four white adult Japanese rabbits were randomly assigned to one of the 3 groups (n = 8 per group): Group I: sham-operation ...

journal_title：Life sciences

authors： Yu QJ,Wang YL,Zhou QS,Huang HB,Tian SF,Duan DM

更新日期：2006-09-05 00:00:00

abstract：:The characteristics and distribution of putative thyrotropin releasing hormone (TRH) receptors were studied in rat central nervous system using the TRH analogue 3H-(3MeHis2)TRH as a radiolabeled ligand. The analogue had a dissociation constant of 2.3 +/- 0.2 nM and a receptor density of 34 +/- 2 fm/mg protein in whole...

journal_title：Life sciences

authors： Simasko SM,Horita A

更新日期：1982-05-24 00:00:00

abstract：AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...

journal_title：Life sciences

authors： Zhang M,Xie Y,Yan R,Shan H,Tang J,Cai Y,Yin J,Chen M,Zhang J,Yang X,Zhang Q,Li Y

更新日期：2016-11-01 00:00:00

abstract：:Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...

journal_title：Life sciences

authors： Henriksen SJ,Chouvet G,Bloom FE

更新日期：1982-10-18 00:00:00

abstract：:Previous studies have shown that cytochrome P450-Arachidonic Acid (P450-AA) metabolites modify the vascular tone of several vessels and that vasopressin (AVP) stimulates P450-AA metabolism. Thus, in the present study, we decided to investigate if the vasoconstrictor effect of AVP is related to activation of P450-AA me...

journal_title：Life sciences

authors： Vazquez B,Rios A,Escalante B

更新日期：1995-01-01 00:00:00

abstract：AIMS:Cyclooxygenase-2 (COX-2)-controlled production of prostaglandin E(2) (PGE(2)) has been implicated in cell growth and metastasis in many cancers. Recent studies have found that COX-2 is co-expressed with survivin in many cancers. Survivin is a member of the inhibitor-of-apoptosis protein family. Some COX-2 inhibito...

journal_title：Life sciences

authors： Bai XM,Jiang H,Ding JX,Peng T,Ma J,Wang YH,Zhang L,Zhang H,Leng J

更新日期：2010-01-30 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...

journal_title：Life sciences

authors： Irwin I,Langston JW

更新日期：1985-01-21 00:00:00

abstract：:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean ar...

journal_title：Life sciences

authors： Wang YX,Crofton JT,Liu H,Sato K,Share L

更新日期：1996-01-01 00:00:00

abstract：:Artemisinin is a promising and a potent antimalarial drug, which meets the dual challenge posed by drug-resistant parasites and rapid progression of malarial illness. This review article focuses on the progress achieved during the last years in the production of artemisinin from Artemisia annua. The structure, biosynt...

journal_title：Life sciences

authors： Dhingra V,Vishweshwar Rao K,Lakshmi Narasu M

更新日期：2000-01-01 00:00:00

abstract：AIMS:The hypoxia-stimulated response of the endocrine system depends on the kind and duration of hypoxia. Hypoxia has been reported to stimulate testosterone (T) production in rats, but the mechanisms remain to be investigated. MATERIALS AND METHODS:Male rats were divided into two groups. The rats exposed to chronic i...

journal_title：Life sciences

authors： Cho YM,Chou JC,Fang CM,Hu S,Wang KL,Wang SW,Wang PS

更新日期：2019-09-15 00:00:00

abstract：:We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...

journal_title：Life sciences

authors： Bousquet P,Feldman J

更新日期：1987-03-16 00:00:00

abstract：:Bile duct ligation (BDL) in rats induces portal fibrosis. This process has been linked to changes in the oxidative state of the hepatic cells and in the production of nitric oxide. Our objective was to find possible temporal connections between hepatic redox state, NO synthesis and liver injury. In this work we have c...

journal_title：Life sciences

authors： Vázquez-Gil MJ,Mesonero MJ,Flores O,Criado M,Hidalgo F,Arévalo MA,Sánchez-Rodríguez A,Tuñón MJ,López-Novoa JM,Esteller A

更新日期：2004-06-25 00:00:00

abstract：:Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for thei...

journal_title：Life sciences

authors： Yu WH,Riedel M,Yamashiro D,Ramasharma K,McCann SM

更新日期：1994-01-01 00:00:00

abstract：:Ro41-0960 is a potent, fluorine containing COMT inhibitor which has be en reported to cross the blood brain barrier and to inhibit COMT in the brain. It is structurally similar to Ro40-7592 which is currently undergoing clinical trials in Parkinson's disease. Positron emission tomographic (PET) studies in baboon using...

journal_title：Life sciences

authors： Ding YS,Gatley SJ,Fowler JS,Chen R,Volkow ND,Logan J,Shea CE,Sugano Y,Koomen J

更新日期：1996-01-01 00:00:00

abstract：:Patients with neurogenic orthostatic hypotension due to multiple system atrophy (MSA) or pure autonomic failure (PAF) excrete lower amounts of homovanillic acid (HVA) than do normal subjects. There is a highly significant correlation between the rates of excretion of HVA and norepinephrine metabolites. The regression ...

journal_title：Life sciences

authors： Kopin IJ,Oliver JA,Polinsky RJ

更新日期：1988-01-01 00:00:00

abstract：:The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic re...

journal_title：Life sciences

authors： Yano T,Nakagawa A,Tsuji M,Noda K

更新日期：1986-09-22 00:00:00

abstract：HEADING AIMS:MicroRNA-27b (miR-27b) has been shown to play a role in the progression of many different forms of cancer, but its specific relevance in the context of non-small cell lung cancer (NSCLC) remains uncertain. As such, this study sought to explore the role of miR-27b in NSCLC and the mechanisms whereby it func...

journal_title：Life sciences

authors： Zhang J,Hua X,Qi N,Han G,Yu J,Yu Y,Wei X,Li H,Chen X,Leng C,Liu Q,Lu Y,Li Y

更新日期：2020-08-01 00:00:00

abstract：:The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...

journal_title：Life sciences

authors： McDougall SA,Neisewander JL,Bardo MT,Zolman JF

更新日期：1989-01-01 00:00:00

abstract：:The aim of the present study was to investigate the existence of aging- and sex-related alterations in the permeability of the blood-brain barrier (BBB) in the rat, by calculating a unidirectional blood-to-brain transfer constant (Ki) for the circulating tracer [14C]-alpha-aminoisobutyric acid. We observed that: a) th...

journal_title：Life sciences

authors： Saija A,Princi P,D'Amico N,De Pasquale R,Costa G

更新日期：1990-01-01 00:00:00

abstract：:The role of extracellular acidosis in inflammatory airway diseases is not well known. One consequence of tissue acidification is the stimulation of sensory nerves via the polymodal H(+)-gated transmembrane channels ASICs and TRPV1 receptor. The present study investigated the effect of acidosis on airway basal tone and...

journal_title：Life sciences

authors： Faisy C,Planquette B,Naline E,Risse PA,Frossard N,Fagon JY,Advenier C,Devillier P

更新日期：2007-09-08 00:00:00

abstract：:The kinetic parameters of serotonin (5-HT) uptake and imipramine binding of the synaptosomes and blood platelets of male Fawn-hooded rats, which have a 5-HT storage abnormality, and normal Sprague-Dawley rats were compared. The Vmax for 5-HT uptake of synaptosomes from Fawn-hooded rats was significantly greater than t...

journal_title：Life sciences

authors： Arora RC,Tong C,Jackman HL,Stoff D,Meltzer HY

更新日期：1983-08-01 00:00:00

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：:The circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been determined in male and female rats at 3 weeks and at 2, 8, 14 and 20 months of age. All animals have a pronounced circadian pattern of aMT6s excretion under a 12 hour dark: 12 hour light cycle. A significant increase in aMT6s excretion is observe...

journal_title：Life sciences

authors： Yie SM,Liu GY,Johansson E,Brown C,Brown GM

更新日期：1992-01-01 00:00:00

abstract：:Activation of polyamine metabolism may be important to initiation of pancreatic cell growth. We are reporting that such activation did occur during pancreatic growth initiation by caerulein, a cholecystokinin analog. Maximal increases in total putrescine (319%), spermidine (63%) and spermine (50%) were observed 12, 96...

journal_title：Life sciences

authors： Morisset J,Benrezzak O

更新日期：1984-12-10 00:00:00

abstract：:The reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (DAT). Though cocaine and methylphenidate have similar in vitro affinities for DAT the abuse of methylphenidate in humans is substantially lower than of cocaine. To test if differences in in vivo pot...

journal_title：Life sciences

authors： Volkow ND,Wang GJ,Fowler JS,Fischman M,Foltin R,Abumrad NN,Gatley SJ,Logan J,Wong C,Gifford A,Ding YS,Hitzemann R,Pappas N

更新日期：1999-01-01 00:00:00

abstract：:The effects of t-butylhydroperoxide (TBH) and cigarette smoke on lung mechanics (CDYN and RL) and glutathione status (GSH) were studied using an isolated perfused and ventilated rat lung preparation. TBH (200, 400, 1000 microM) infused via the pulmonary circulation caused a dose-related bronchoconstriction. The lung G...

journal_title：Life sciences

authors： Ryrfeldt A,Kröll F,Berggren M,Moldéus P

更新日期：1988-01-01 00:00:00

abstract：:The inhibitory activity of methylguanidine, guanidine and their precursors, creatine and creatinine, on both the neuronal constitutive and lung inducible isoforms of nitric oxide synthase were examined in this study. Methylguanidine and guanidine (0.01-3 mM) significantly (P<0.01) inhibited in a concentration-dependen...

journal_title：Life sciences

authors： Sorrentino R,Sautebin L,Pinto A

更新日期：1997-01-01 00:00:00

abstract：:Biphasic cutaneous reaction with peak response at 1 (early phase) and 24 to 48 hour (late phase) was elicited by epicutaneous challenge with antigen in actively and passively sensitized mice. Mice were actively immunized with dinitrophenylated (DNP) ascaris antigen and challenged with dinitrofluorobenzene (DNFB). Pass...

journal_title：Life sciences

authors： Sakurai T,Inagaki N,Nagai H

更新日期：1994-01-01 00:00:00

abstract：:Somatostatin (SS) acts as a universal endocrine off-swich, and also inhibits the growth of neuroendocrine tumors through its specific receptors. Small cell lung cancer (SCLC) demonstrates some neuroendocrine characteristics and has been proposed as a candidate for treatment with SS and its analogues. In the present st...

journal_title：Life sciences

authors： Fujita T,Yamaji Y,Sato M,Murao K,Takahara J

更新日期：1994-01-01 00:00:00

abstract：:The activation of cholinergic pathways by nicotine elicits various physiological and pharmacological effects in mammals. For example, the stimulation of nicotinic acetylcholine receptors (nAChRs) leads to an antinociceptive effect. However, it remains to be elucidated which subtypes of nAChR are involved in the antino...

journal_title：Life sciences

authors： Abdin MJ,Morioka N,Morita K,Kitayama T,Kitayama S,Nakashima T,Dohi T

更新日期：2006-12-03 00:00:00