Abstract:
:Patients with neurogenic orthostatic hypotension due to multiple system atrophy (MSA) or pure autonomic failure (PAF) excrete lower amounts of homovanillic acid (HVA) than do normal subjects. There is a highly significant correlation between the rates of excretion of HVA and norepinephrine metabolites. The regression line relating excretion of the dopamine and norepinephrine metabolites suggests that about one third of dopamine formed in noradrenergic neurons is converted to norepinephrine and the remainder metabolized, mainly to HVA. About one fourth of urinary HVA appears to be derived from a source independent of norepinephrine; this source is probably brain dopaminergic neurons.
journal_name
Life Scijournal_title
Life sciencesauthors
Kopin IJ,Oliver JA,Polinsky RJdoi
10.1016/0024-3205(88)90289-5subject
Has Abstractpub_date
1988-01-01 00:00:00pages
125-31issue
2eissn
0024-3205issn
1879-0631pii
0024-3205(88)90289-5journal_volume
43pub_type
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