Abstract:
:The aim of the present study was to assess the effects of peanut (Arachis hypogaea L.) shell extracts (PSE) on lipases and to evaluate its potential development for the treatment of obesity. The peanut shells were extracted in 95% ethanol, and the extracts were screened for inhibitory effects on pancreatic lipase (PL) and lipoprotein lipase (LPL) activities as well as on lipolysis of 3T3-L1 adipocytes. We also examined in vivo whether PSE could prevent the body weight gain induced by feeding a high-fat diet to male Wistar rats for 12 weeks. PSE inhibits a number of lipases, including PL, LPL and, possibly, hormone sensitive lipase (HSL). PSE-treated Wistar rats showed increased fecal lipid excretion respect to the control group. Body weight and body weight gain, and liver size, were significantly lower in rats fed the high-fat diet with 1% of PSE (w:w diet) than in those fed the high-fat diet alone. The rats treated with PSE showed reduced triacylglycerol content in the liver, as well as the serum glucose and insulin. The inhibitory activity of PSE on the lipid metabolic enzymes and the increase in fecal fat excretion suggests that PSE might be useful as a treatment to reduce the dietary fat absorption. The observed reduction in intracellular lipolytic activity of cultured 3T3-L1 adipocytes may reduce the levels of circulating free fatty acids. The observed effects are likely induced by more than one bioactive component of PSE. The PSE actions may, at least in part, be attributed to the inhibition of fat absorption in the digestive tract and the reduction of the adipocyte lipolysis.
journal_name
Life Scijournal_title
Life sciencesauthors
Moreno DA,Ilic N,Poulev A,Raskin Idoi
10.1016/j.lfs.2005.11.012subject
Has Abstractpub_date
2006-05-08 00:00:00pages
2797-803issue
24eissn
0024-3205issn
1879-0631pii
S0024-3205(05)01200-2journal_volume
78pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Cardiovascular risk factors associated with hypertension include alterations in arterial compliance and an increased tendency to thrombosis. In this study we examined the relationship between arterial compliance and endothelial derived components of the hemostatic system: von Willebrand factor (vWF) and tissue plasmin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90192-6
更新日期:1993-01-01 00:00:00
abstract::The ontogeny of endothelin (ET) system in rats was studied in preterm (18 days of gestation), term (21 days of gestation) and 1 week post term rats. Brains were dissected out and (1) processed for the estimation of endogenous ET-1 by RIA and (2) membranes were prepared for radioreceptor binding. Receptor characteristi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90300-e
更新日期:1992-01-01 00:00:00
abstract::In rat brain microvessels, tetrahydroaminoacridine (THA) caused a significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, in a dose-dependent manner. THA resulted to be a more potent inhibitor of BuChE than AChE. Lineweaver-Burk plots showed that Km (app) and V were alt...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90553-f
更新日期:1993-01-01 00:00:00
abstract::Cannabinoid agonists such as Delta9-tetrahydrocannabinol (THC) produce a wide range of pharmacological effects both in the central nervous system and in the periphery. One of the most striking features of cannabinoids such as THC is the magnitude to tolerance that can be produced upon repetitive administration of this...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2005.05.005
更新日期:2005-08-19 00:00:00
abstract:AIMS:MicroRNA-1 (miR-1) has been demonstrated as a tumor-suppressive miRNA, which shows a down-regulated pattern in several human malignancies including hepatocellular carcinoma (HCC). However, the pathophysiologic roles of miR-1 and their mechanisms in HCC tumorigenesis are still not totally elucidated. MAIN METHODS:...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.08.015
更新日期:2012-10-05 00:00:00
abstract::The effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue was investigated and compared with other a-adrenergic antagonists. Moxisylyte produced a concentration-dependent relaxation of a norepinephrine-induced (1 x 10(-5) M) contraction of the corpus cavernosum tissue. Pretreatment with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90194-x
更新日期:1989-01-01 00:00:00
abstract::Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00024-0
更新日期:1996-01-01 00:00:00
abstract::The enkephalin analogs, [D-Pen2,L-Cys5]- and [D-Pen2,D-Cys5]-enkephalin are cyclic compounds, conformationally constrained by virtue of their 14-membered, disulfide containing rings and by the rigidizing effect of the beta, beta dimethyl substituents of the penicillamine side chain. The analogs exhibit profound delta ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90239-4
更新日期:1983-05-30 00:00:00
abstract::Psoriasis is an inflammatory skin disease with preference for the skin and joints that occurs due to hyper-proliferation and abnormal apoptosis of keratinocytes. DUSP1 expression in dermal mesenchymal stem cells (MSCs) is obviously lower in psoriasis patients than that in healthy individuals. The present study aimed t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.03.018
更新日期:2019-04-15 00:00:00
abstract:AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.12.015
更新日期:2017-03-01 00:00:00
abstract::Although one of the major genes which cause type 1 (insulin-dependent) diabetes mellitus is located in the class II HLA region in humans, its precise location is still unknown. In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00713-6
更新日期:1994-01-01 00:00:00
abstract::5-Bromo-2'-deoxyuridine (BrdU) has been recently found to enhance adrenal glucocorticoid secretion in rats. Since BrdU-labeling is today the most employed technique for assessing cell proliferation, we have investigated whether this side-effect of BrdU may influence mitotic activity (as evaluated by metaphase-arrested...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00439-6
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117173
更新日期:2020-01-15 00:00:00
abstract:AIMS:We investigated the effects of chemical stimulation of cerebellum fastigial nucleus (FN) on the chronic visceral hypersensitivity (CVH) and its possible mechanism in rats. MAIN METHODS:We stimulated the FN by microinjecting glutamate into the FN, in order to explore whether the cerebellum fastigial nucleus played...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.04.043
更新日期:2018-06-15 00:00:00
abstract::Release of alpha-MSH from the pars intermedia melanotrope cells of Xenopus laevis is regulated by various classical neurotransmitters and neuropeptides. We have examined the effect of two of these regulatory substances, the neurotransmitter GABA and the CRF-related peptide sauvagine, on the adenylate cyclase system of...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90123-s
更新日期:1991-01-01 00:00:00
abstract::The present study was planned to determine the mechanisms involved in the renal vasodilation caused by insulin. Changes in flow caused by the intravenous infusion of 0.004 IU/kg/min of insulin at constant heart rate, aortic blood pressure, left ventricular contractility and blood levels of glucose and potassium in the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01257-7
更新日期:2001-08-24 00:00:00
abstract::Four Rhesus monkeys were subjected to daily administration of 2.5 mg of tetrahydrocannabinol (THC)/kg body wt, after establishing the norms for complete blood count, T- and B-cell concentrations, and the dose response of thymidine incorporation after PHA stimulation. THC was administered daily for 3 weeks, the treatme...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90642-7
更新日期:1982-01-04 00:00:00
abstract::In view of the toxicity of cocaine and recent reports on the antimuscarinic properties of cocaine, the present study evaluated the effects of manipulations in cholinergic neurotransmission on the lethal effects of cocaine. Physostigmine pretreatment significantly altered the lethality of cocaine, increasing the LD 50 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90111-2
更新日期:1989-01-01 00:00:00
abstract::Dialyzed aqueous extracts of plant pollen are widely used in the clinical practice of allergy for diagnostic and therapeutic purposes. The present investigation shows that such allergenic extracts are capable of consuming complement in every human serum, independent of the clinical condition. Complement is engaged by ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00101-x
更新日期:1997-01-01 00:00:00
abstract::Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00411-1
更新日期:1998-01-01 00:00:00
abstract::Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00170-2
更新日期:1998-01-01 00:00:00
abstract::The purpose of the this study was to characterize the putative anxiolytic-like effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before beh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.05.024
更新日期:2004-10-22 00:00:00
abstract::The Thirteenth International Conference on Endothelin (ET-13) was held from September 8-11, 2013 in Tokyo, Japan chaired by Noriaki Emoto, Kobe Pharmaceutical University, Japan, and Takashi Miyauchi, University of Tsukuba, Japan and held on the Tokyo Campus of Tsukuba University. The International Conferences on Endot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.09.020
更新日期:2014-11-24 00:00:00
abstract::To characterize the pharmacokinetics of protein-free granisetron in blood and brain we implanted microdialysis probes into the jugular vein and cerebral frontal cortex of the rat. Granisetron (3 or 6 mg/kg, i.v., n=6) was then administered, and microdialysates from blood and brain were collected from both sites and as...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00143-5
更新日期:1999-01-01 00:00:00
abstract:AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118268
更新日期:2020-10-15 00:00:00
abstract::Dopaminergic agents ameliorate experimentally induced gastroduodenal mucosal injury, but there is no information about their effect on small intestinal mucosa. We studied the effect of L-dopa and related substances on indomethacin-induced intestinal ulceration in the rat. Ulceration was produced by s.c. injection of 3...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90517-s
更新日期:1992-01-01 00:00:00
abstract:UNLABELLED:Isolation of meiotic arrested oocytes from mammalian ovaries involves a resumption of the meiosis. Studying the effect of FSH on this process it was found that doses up to of 0.1 IU/ml did not maintain the meiotic arrest in hamster oocytes in pre-antral follicles during static incubation conditions. However,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90045-0
更新日期:1994-01-01 00:00:00
abstract:AIM:The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. MAIN METHODS:The data obtained from MTT assays, performed on cells treated with protolichester...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.023
更新日期:2016-08-01 00:00:00
abstract::Several cryopreservation methods for precision-cut rat liver slices (PCLS) have been proposed, allowing a short-term (a few hours) maintainance of viability and functionality upon thawing. The aim of the present study was to test the metabolic capacity of PCLS cryopreserved by an ultrarapid method. The biotransformati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01031-1
更新日期:2001-04-13 00:00:00
abstract::We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimmin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01206-1
更新日期:2001-07-27 00:00:00