Abstract：
PURPOSE:Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decrease in the cardiotoxic effect induced by doxorubicin. The aim of this review was to evaluate the potential role of melatonin in the prevention of doxorubicin-induced cardiotoxicity. METHODS:This review was conducted by a full systematic search strategy based on PRISMA guidelines for the identification of relevant literature in the electronic databases of PubMed, Web of Science, Embase, and Scopus up to January 2019 using search terms in the titles and abstracts. 286 articles were screened in accordance with our inclusion and exclusion criteria. Finally, 28 articles were selected in this systematic review. RESULTS:The findings demonstrated that doxorubicin-treated groups had increased mortality, decreased body weight and heart weight, and increased ascites compared to the control groups; the co-administration of melatonin revealed an opposite pattern compared to the doxorubicin-treated groups. Also, this chemotherapeutic agent can lead to biochemical and histopathological changes; as for most of the cases, these alterations were reversed near to normal levels (control groups) by melatonin co-administration. Melatonin exerts these protection effects through mechanisms of anti-oxidant, anti-apoptosis, anti-inflammatory, and mitochondrial function. CONCLUSION:The results of this systematic review indicated that co-administration of melatonin ameliorates the doxorubicin-induced cardiotoxicity.
journal_name
Life Scijournal_title
Life sciencesauthors
Najafi M,Hooshangi Shayesteh MR,Mortezaee K,Farhood B,Haghi-Aminjan Hdoi
10.1016/j.lfs.2019.117173subject
Has Abstractpub_date
2020-01-15 00:00:00pages
117173eissn
0024-3205issn
1879-0631pii
S0024-3205(19)31101-4journal_volume
241pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Based on the finding of decreased mitochondrial complex I activity in the substantia nigra of patients with Parkinson's disease, we propose that the consequent reduction of ATP synthesis and increased generation of reactive oxygen species may be a possible cause of nigrostriatal cell death. Since sulfhydryl groups are...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(98)00472-x
更新日期：1999-01-01 00:00:00
abstract：:The effects of the novel anticonvulsant felbamate, which binds to the 5-7 dichlorokynurenic binding sites, were tested towards the CA1 epileptiform activity induced in rat hippocampal slices by kainic acid. The effects of the kynurenic acid derivatives 7-chlorokynurenic acid and 5-7 dichlorokynurenic acid and of the N...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00251-2
更新日期：1996-05-24 00:00:00
abstract：:The melanocortins are a family of bioactive peptides derived from proopiomelanocortin. Those peptides, included among hormones and comprising ACTH, alpha-MSH, beta-MSH and gamma-MSH, are best known mainly for their physiological effects, such as the control of skin pigmentation by alpha-MSH, and ACTH effects on pigmen...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(03)00349-7
更新日期：2003-07-04 00:00:00
abstract：AIM:To compare embryonic developmental competence and clinical outcomes of oocytes matured in vivo (IVF oocytes) and those matured in vitro (IVM oocytes) from the same IVM/IVF cycles, and to analyze the clinical efficiency of a melatonin-supplemented in vitro maturation system combined with a modified IVM/IVF protocol....
journal_title：Life sciences
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.lfs.2020.118706
更新日期：2021-01-01 00:00:00
abstract：:We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00363-3
更新日期：1996-01-01 00:00:00
abstract：:Maintenance of the cellular calcium homeostasis plays an important role for neuronal cell function and interneuronal cell to cell communication. Therefore, alterations of the neuronal Ca2+ homeostasis may play a crucial role for brain aging in general and for age-related deficits in cognitive functions particularly. N...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)00381-5
更新日期：1994-01-01 00:00:00
abstract：:Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90137-3
更新日期：1988-01-01 00:00:00
abstract：:The relative affinities of nortriptyline (NT) and its 10-hydroxymetabolites to rat brain muscarinic acetylcholine receptors have been determined by competition with 3H-quinuclidinyl benzilate binding. It is shown that the major NT metabolite, E-10-OH-NT, has only 1/18 the affinity of NT for the muscarinic receptor. Si...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90395-3
更新日期：1984-09-24 00:00:00
abstract：:Platelet functions are becoming the useful tool for delineating the etiology of pregnancy induced hypertension. Electronmicroscopic studies, efflux and content of 5-HT in platelets and platelet aggregation responses towards various aggregating agents have been measured in 25 normotensive pregnant subjects and 31 PIH s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00735-7
更新日期：1994-01-01 00:00:00
abstract：:Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118509
更新日期：2020-12-01 00:00:00
abstract：AIMS:Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.011
更新日期：2019-04-15 00:00:00
abstract：:Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.08.015
更新日期：2007-09-08 00:00:00
abstract：:The effects of chronic treatment with piracetam (100 mg/Kg) plus choline (100 mg/Kg) on rabbits' hippocampal electrical activity and behavior have been studied. Animals were exposed to a neutral environment, in the absence of any external stimulus, and then to an object and a stuffed sparrow-hawk. Results show a drug ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90189-9
更新日期：1984-09-10 00:00:00
abstract：:Different receptors mediating the release of endothelium-derived nitric oxide (EDNO) have been identified at endothelial level. In the present study we aimed to characterise, on rabbit aorta by means of pharmacological tools, the generation of EDNO by receptors located on endothelial cell membrane (M3, P2u, P2y) and b...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01144-2
更新日期：1998-01-01 00:00:00
abstract：:We have previously shown that transforming growth factor-beta1 (TGF-beta1) is involved in the fibroblast-induced organization and differentiation of transformed phenotypically crypt-like T84 intestinal epithelial cells into absorptive enterocyte-like cells, when cultured within a three-dimensional collagen gel. We hav...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01216-4
更新日期：2001-08-10 00:00:00
abstract：:We previously demonstrated that tissue-type plasminogen activator (t-PA) specifically bound to its receptor (t-PAR) on human umbilical vein endothelial cells (HUVEC). In addition to analyses of t-PA binding to plasminogen activator inhibitor-1 (PAI-1) in the extracellular matrix (ECM) and to the t-PAR, we further eval...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)80007-7
更新日期：2000-01-01 00:00:00
abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90609-f
更新日期：1991-01-01 00:00:00
abstract：:Nitric oxide (NO) is a potent regulator in the cardiovascular system; it is generated by the nitric oxide synthase (NOS) family of proteins. NO produced in endothelial cells plays a crucial role in vascular functions. The aim of this study was to clarify the effect of diabetes on aortic NO synthesis in a model of gene...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.02.010
更新日期：2005-07-15 00:00:00
abstract：:The effect of oral administration of Clostridium butyricum Miyairi on the formation and dissolution of gallstones was examined in a mouse model of cholesterol cholelithiasis, in comparison with that of chenodeoxycholic acid (CDCA). A diet containing cholesterol and sodium cholate was used as a lithogenic diet. The fee...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90149-2
更新日期：1983-01-31 00:00:00
abstract：:According to recent epidemiological reports, almost 40% of American population use complimentary and alternative medicine (CAM) during their lifetime. Patients detected with HIV or cancer often consume herbal products especially St. John's wort (SJW) for antidepressants in combination with prescription medicines. Such...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2005.12.010
更新日期：2006-03-27 00:00:00
abstract：:The potential photoaffinity ligand 14-beta-(o-nitro, p-azido)-cinnamoyl-amino-N-cyclopropylmethylnormorphinone (NAM) and its derivative NOM, lacking the p-azido function, were synthesised and their opiate receptor activity determined in isolated tissue preparations. The ligands showed slow receptor kinetics. NAM was a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90536-2
更新日期：1983-01-01 00:00:00
abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.05.008
更新日期：2009-07-31 00:00:00
abstract：AIMS:Oxidative stress emerges after reperfusion of an organ following an ischemic period and results in tissue damage. In the heart, an amplified generation of reactive oxygen species and a significant Ca(2+) accumulation cause ventricular arrhythmias and mitochondrial dysfunction. This occurs in consequence of increas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.12.026
更新日期：2014-02-06 00:00:00
abstract：:Polyamines (spermidine, spermine and putrescine) inhibited the adenylate cyclase activity in a concentration dependent manner in human erythrocyte plasma membranes. Spermidine (Spd) exhibited more inhibitory effect than spermine (Spm) and putrescine (Put). On the contrary, the addition of amino acids (arginine, glutam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90055-v
更新日期：1990-01-01 00:00:00
abstract：:The validity of a photoelectric method for continuous cerebral blood volume (CBV) measurement was tested and modified for the rat's brain. A new way of introducing a miniature light source between the two hemispheres and fixing a light sensitive silicone blue cell to the outer surface of the parietal bone was develope...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90163-3
更新日期：1986-11-03 00:00:00
abstract：:Bufalin, which is one of prominent components of Chinese toad venom, was found to decrease the rate of cell proliferation of mouse melanoma clone B16-F10 cells and a concomitant stimulation of expression of its melanotic phenotype. The effect of bufalin on melanogenesis included stimulation of tyrosinase activity and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90213-9
更新日期：1992-01-01 00:00:00
abstract：:In the present study we compared, in vivo in rats, the hepatobiliary transport of monovalent (silver:Ag) and divalent metals (zinc:Zn; cadmium:Cd) with that of copper (Cu). Cu can have two oxidation states in vivo, i.e. Cu(I) and Cu(II). Studies were performed in normal Wistar (NW) rats and mutant GY Wistar rats. The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00447-x
更新日期：1996-01-01 00:00:00
abstract：AIMS:Diabetic nephropathy is a growing health concern, which is reported to be associated with inflammation. Luteolin has been explored for the treatment of some diabetic complications. Although several studies have verified the effect of luteolin on diabetic nephropathy, the mechanism by which the therapeutic effects ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.073
更新日期：2019-05-15 00:00:00
abstract：:The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90626-1
更新日期：1988-01-01 00:00:00
abstract：:Because ethanol elicits a dose-dependent hydrolysis of brain sialogangliosides, we tested the possibility that injected gangliosides might antagonize intoxicating doses of ethanol. Clear anti-intoxication effects were seen at 24 hr post-injection of mixed mouse-brain gangliosides at 125-130 mg/kg, but not at lower or ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90284-6
更新日期：1988-01-01 00:00:00
