当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Effects of felbamate, kynurenic acid derivatives and NMDA antagonists on in vitro kainate-induced epileptiform activity.

Effects of felbamate, kynurenic acid derivatives and NMDA antagonists on in vitro kainate-induced epileptiform activity.

Abstract：

:The effects of the novel anticonvulsant felbamate, which binds to the 5-7 dichlorokynurenic binding sites, were tested towards the CA1 epileptiform activity induced in rat hippocampal slices by kainic acid. The effects of the kynurenic acid derivatives 7-chlorokynurenic acid and 5-7 dichlorokynurenic acid and of the NMDA antagonists CGS 19755, MK-801 and ketamine were also studied for comparison. Slice perfusion with 1 microM kainic acid produced within 30 min the development of an evoked CA1 epileptiform bursting made up by an increase in amplitude of the primary population spikes followed by the appearance of secondary epileptiform population spikes. Slice perfusion with CGS 19755 (100 microM) or MK-801 (100 microM) or ketamine (100 microM) failed to affect within 30 min the CA1 epileptiform activity due to kainic acid. On the contrary, slice perfusion with felbamate (1.3-1.6 mM) or 7-chlorokynurenic acid (100 microM) or 5-7-dichlorokynurenic acid (100 microM) produced within 30 min a significative (p < 0.05) decrease of the kainate-induced epileptiform bursting duration. The results indicate that felbamate and kynurenic acid derivatives but not NMDA antagonists present an inhibitory effect against the epileptiform activity due to kainic acid.

journal_name

Life Sci

journal_title

Life sciences

authors

Domenici MR,Marinelli S,Sagratella S

doi

10.1016/0024-3205(96)00251-2

subject

Has Abstract

pub_date

1996-05-24 00:00:00

pages

PL391-6

issue

26

eissn

0024-3205

issn

1879-0631

pii

0024320596002512

journal_volume

58

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Age-associated changes and sex differences in urinary 6-sulphatoxymelatonin circadian rhythm in the rat.

    abstract：:The circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been determined in male and female rats at 3 weeks and at 2, 8, 14 and 20 months of age. All animals have a pronounced circadian pattern of aMT6s excretion under a 12 hour dark: 12 hour light cycle. A significant increase in aMT6s excretion is observe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90323-h

    authors： Yie SM,Liu GY,Johansson E,Brown C,Brown GM

    更新日期：1992-01-01 00:00:00

  • Characterization of type 2 opiate receptors.

    abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90183-7

    authors： Olgiati V,Quirion R,Bowen WD,Pert CB

    更新日期：1982-10-18 00:00:00

  • Hepatoprotective effect of celecoxib against tamoxifen-induced liver injury via inhibiting ASK-1/JNK pathway in female rats.

    abstract：:Hepatotoxicity is a common side effect encountered with tamoxifen (TAM) administration. Due to the great value of TAM in breast cancer treatment, hepato-protection is seriously recommended. AIMS:The present study investigated the hepato-protective effect of celecoxib (CX) against TAM-induced hepatotoxicity in rats. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116573

    authors： El-Kashef DH,El-Sheakh AR

    更新日期：2019-08-15 00:00:00

  • Skin permeability of various non-steroidal anti-inflammatory drugs in man.

    abstract：:The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic re...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90195-5

    authors： Yano T,Nakagawa A,Tsuji M,Noda K

    更新日期：1986-09-22 00:00:00

  • Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes.

    abstract：:[3H]5-HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus (CN). [3H]5-HT labeled both 5-HT1A and 5-HT1C recognition sites, defined by nanomolar affinity for 8-OH-DPAT and mesulergine respectively; however, these represented only a fraction of total specific [3H]5-HT binding. Saturation...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90033-7

    authors： Xiong WC,Nelson DL

    更新日期：1989-01-01 00:00:00

  • Deglycation of glycated proteins with hydrazine analogues.

    abstract：:Glycated human serum albumin (glc HSA) and glc proteins in back hairs from diabetic rats were deglycated by incubation with hydrazine or aminoguanidine (guanylhydrazine) at physiological temperature (37 degrees C). Glc HSA decreased by 35% with 0.2 M hydrazine at day 20 and by 56% with 0.1 M aminoguanidine at day 10. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90681-r

    authors： Kobayashi K,Yoshimoto K,Hirauchi K,Uchida K

    更新日期：1993-01-01 00:00:00

  • Separation of rabbit ileum mucus secretion from electrolyte and water secretion by cholera enterotoxin, verapamil and A23187.

    abstract：:Net water, Na+, Cl- and HCO3- fluxes were measured in in vivo rabbit ileal loops, while mucus secretion was assessed by measuring the glycoprotein or total sialic acid secreted into the lumen, or by measuring the luminal fluid viscosity. Inoculating loops with cholera enterotoxin (CT) produced a sustained secretion of...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90220-5

    authors： George MH,Leitch GJ

    更新日期：1983-02-21 00:00:00

  • Impact of treadmill exercise on early apoptotic cells in mouse thymus and spleen.

    abstract：:Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00551-7

    authors： Hoffman-Goetz L,Zajchowski S,Aldred A

    更新日期：1999-01-01 00:00:00

  • Flavonoids from the leaves of Diospyros kaki reduce hydrogen peroxide-induced injury of NG108-15 cells.

    abstract：:Flavonoids from the leaves of Diospyros kaki L (FLDK-P70) are main therapeutic components of NaoXingQing, which is a novel and patented Traditional Chinese Medicine drug used for the treatment of syndrome of apoplexy for years in China. The present study investigated the effects of FLDK-P70 on hydrogen peroxide (H2O2)...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.09.031

    authors： Bei W,Peng W,Ma Y,Xu A

    更新日期：2005-03-11 00:00:00

  • Pulmonary toxicity caused by acute exposure to mercury vapor is enhanced in metallothionein-null mice.

    abstract：:This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00129-0

    authors： Yoshida M,Satoh M,Shimada A,Yasutake A,Sumi Y,Tohyama C

    更新日期：1999-01-01 00:00:00

  • Effect of angiotensin II on a spinal nociceptive reflex in the rat: receptor and mechanism of action.

    abstract：:The effect on thermonociceptive threshold of intrathecally (i.t.) administered angiotensin II (Ang II) was assessed in the rat tail-flick test. Rats were pretreated, 15 min earlier, with i.t. naloxone (opiate antagonist), losartan (Ang II selective antagonist at AT1 receptor) or [Sar1, Leu8] Ang II (non selective Ang ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00410-4

    authors： Toma N,Sgambato V,Couture R

    更新日期：1997-01-01 00:00:00

  • Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats.

    abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00241-6

    authors： Matsuda H,Li Y,Yoshikawa M

    更新日期：1999-01-01 00:00:00

  • Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia.

    abstract：AIMS:Smokers have lower plasma concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) compared with nonsmokers. To determine the molecular basis of this observation, the effect of activation of the aryl hydrocarbon receptor (AhR) on apo A-I gene expression was examined. MAIN METH...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2012.06.002

    authors： Naem E,Alcalde R,Gladysz M,Mesliniene S,Jaimungal S,Sheikh-Ali M,Haas MJ,Wong NC,Mooradian AD

    更新日期：2012-07-26 00:00:00

  • Apoptosis-like cell death of human breast cancer cell line MCF-7 induced by buprenorphine hydrochloride.

    abstract：:The analgesic buprenorphine hydrochloride (Bph) induced apoptosis-like cell death in the caspase-3-deficient human breast cancer cell line, MCF-7. This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6. Bph caused the release of ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.11.032

    authors： Kugawa F,Matsumoto K,Aoki M

    更新日期：2004-06-04 00:00:00

  • A novel 2,3-benzodiazepine-4-one derivative AMPA antagonist inhibits G2/M transition and induces apoptosis in human leukemia Jurkat T cell line.

    abstract：:It has been shown that the antagonism of glutamate receptors activity was able inhibit proliferation and induce apoptosis in several neuronal and non-neuronal cancer cell lines. In addition, it has been shown that glutamate might facilitate the spread and growth of leukemia T cells through interactions with AMPA recep...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.03.051

    authors： Parenti S,Casagrande G,Montanari M,Espahbodinia M,Ettari R,Grande A,Corsi L

    更新日期：2016-05-01 00:00:00

  • Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2.

    abstract：:Using a dipole tracing method based on the two-dipole model, the purpose of the present study was to investigate alcohol-induced changes in the alpha band of electroencephalogram (EEG) and its equivalent current dipoles (ECDs) in 12 healthy male volunteers, who were genetically typed for mitochondrial aldehyde dehydro...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00707-4

    authors： Hara K,Terasaki O,Okubo Y

    更新日期：2000-01-01 00:00:00

  • The level of effort, rather than muscle exercise intensity determines strength gain following a six-week training.

    abstract：AIM:This study investigated the effect of voluntary motor effort during a low-intensity (30% maximal voluntary contraction [MVC]) muscle exercise training program on increasing muscle strength. MATERIALS AND METHODS:Eighteen young and healthy individuals were randomly assigned to one of three groups: high mental effor...

    journal_title：Life sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.lfs.2017.04.003

    authors： Jiang CH,Ranganathan VK,Siemionow V,Yue GH

    更新日期：2017-06-01 00:00:00

  • Pressor and cardioaccelerator effects of gamma MSH and related peptides.

    abstract：:We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90197-3

    authors： Klein MC,Hutchins PM,Lymangrover JR,Gruber KA

    更新日期：1985-02-25 00:00:00

  • Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats.

    abstract：:The effect of resveratrol, a polyphenolic compound present in grapes and other plants, on proteinuria, hypoalbuminemia and hyperlipidemia was studied in rats with glomerulonephritis. The nephritis was induced by an intravenous injection of anti-rat kidney glomerular basement membrane rabbit antiserum. Nephritic rats w...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01061-x

    authors： Nihei T,Miura Y,Yagasaki K

    更新日期：2001-05-11 00:00:00

  • Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels.

    abstract：:After 7 years from its cloning, the transient receptor potential vanilloid type-1 (TRPV1) channel remains the sole membrane receptor mediating the pharmacological effects of the hot chilli pepper pungent component, capsaicin, and of the Euphorbia toxin, resiniferatoxin. Yet, this ion channel represents one of the most...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2005.05.021

    authors： De Petrocellis L,Di Marzo V

    更新日期：2005-08-19 00:00:00

  • Improvement of the isoprenaline infusion test by plasma concentration measurements.

    abstract：:A simple and sensitive method for the determination of isoprenaline (ISO) in plasma by high performance liquid chromatography (HPLC) with electrochemical detection is presented. Blood pressure and heart rate responses to i.v. infusion of ISO (15, 38 and 76 ng/kg/min) were studied in 15 subjects. Blood samples for ISO ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90044-5

    authors： Hjemdahl P,Martinsson A,Larsson K

    更新日期：1986-08-18 00:00:00

  • Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer.

    abstract：:Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensi...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2006.07.036

    authors： Stuart EC,Scandlyn MJ,Rosengren RJ

    更新日期：2006-11-17 00:00:00

  • Chlorpromazine exacerbates hepatic insulin sensitivity via attenuating insulin and leptin signaling pathway, while exercise partially reverses the adverse effects.

    abstract：:Investigated in this study are the effects and mechanisms of exercise and chlorpromazine (CPZ), a widely used conventional antipsychotic drug, on the hepatic insulin sensitivity of 90% pancreatectomized (Px) male Sprague-Dawley rats. The Px diabetic rats were provided with 0, 5, or 50 mg CPZ per kg of body weight (No-...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.04.001

    authors： Park S,Hong SM,Lee JE,Sung SR

    更新日期：2007-06-06 00:00:00

  • Possible involvement of activation of P53/P21 and demethylation of RUNX 3 in the cytotoxicity against Lovo cells induced by 5-Aza-2'-deoxycytidine.

    abstract：AIMS:In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms. MAIN METHODS:After Lovo cells were treated with 5-Aza-CdR at different concentrations for different periods of time, the cell viability...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.12.015

    authors： Deng T,Zhang Y

    更新日期：2009-02-27 00:00:00

  • Intravenous buprenorphine reduces pupil size and the light reflex in humans.

    abstract：:The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred wit...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90026-8

    authors： Pickworth WB,Bunker E,Welch P,Cone E

    更新日期：1991-01-01 00:00:00

  • Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus.

    abstract：:Although one of the major genes which cause type 1 (insulin-dependent) diabetes mellitus is located in the class II HLA region in humans, its precise location is still unknown. In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which a...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00713-6

    authors： Kawaguchi Y,Ikegami H,Fukuda M,Takekawa K,Fujioka Y,Fujisawa T,Ueda H,Ogihara T

    更新日期：1994-01-01 00:00:00

  • Phosphorylation: a molecular switch in opioid tolerance.

    abstract：:Protein phosphorylation is a key posttranslational modification mechanism controlling the conformation and activity of many proteins. Increasing evidence has implicated an essential role of phosphorylation by several major protein kinases in promoting and maintaining opioid tolerance. We review some of the most recent...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2006.05.023

    authors： Wang ZJ,Wang LX

    更新日期：2006-09-27 00:00:00

  • Functional and metabolic evidence for two different vanilloid (VN1 and VN2) receptors in perfused rat hindlimb.

    abstract：:Vanilloid spice principles, including capsaicin, stimulate vasoconstriction in the rat hindlimb perfused at constant flow and, depending on dose, either stimulate or inhibit oxygen consumption by this vascular bed. We now present metabolic and functional evidence for two different vanilloid (VN1 and VN2) receptor type...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00250-a

    authors： Colquhoun EQ,Eldershaw TP,Bennett KL,Hall JL,Dora KA,Clark MG

    更新日期：1995-01-01 00:00:00

  • Stimulation of the Na+,K(+)-ATPase activity of K562 human erythroleukemia cells by triiodothyronine.

    abstract：:The effect of triiodothyronine (T3) on Na+,K(+)-ATPase activity of K562 human erythroleukemic cell was studied to understand why the erythrocyte sodium pump activity is decreased in hyperthyroidism. Na+,K(+)-ATPase activity of K562 cell lysates was assayed by measuring the release of inorganic phosphate (Pi) from ATP....

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90107-z

    authors： Arumanayagam M,Swaminathan R

    更新日期：1992-01-01 00:00:00

  • Effect of extracellular matrix on adhesion, viability, actin cytoskeleton and K+ currents of cells expressing human ether à go-go channels.

    abstract：:Ether à go-go (EAG) potassium channels possess oncogenic properties and have gained great interest as research tools for cancer detection and therapy. Besides, EAG electrophysiological properties are regulated through the cell cycle and determined by cytoskeletal interactions. Thus, because of the pivotal role of extr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.05.014

    authors： Toral C,Mendoza-Garrido ME,Azorín E,Hernández-Gallegos E,Gomora JC,Delgadillo DM,Solano-Agama C,Camacho J

    更新日期：2007-06-27 00:00:00