Abstract：
:This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to over 60% of MT-null mice but did not kill any wild-type mice. More severe pulmonary damage was found by histopathological observation in MT-null mice than in wild-type mice. MT levels in the lung were elevated in wild-type mice after Hg0 vapor exposure, and gel filtration of the lung cytosol revealed that most of the mercury was associated with MT. In MT-null mice, MT levels were below the limit of detection (0.2 microg/g tissue) for the MT assay even after exposure. After exposure to Hg0 vapor for 3 consecutive days, the pulmonary mercury levels in wild-type mice were significantly higher than in MT-null mice. These findings suggest that MT plays a protective role against the acute pulmonary toxicity of Hg0 vapor.
journal_name
Life Scijournal_title
Life sciencesauthors
Yoshida M,Satoh M,Shimada A,Yasutake A,Sumi Y,Tohyama Cdoi
10.1016/s0024-3205(99)00129-0subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1861-7issue
20eissn
0024-3205issn
1879-0631pii
S0024320599001290journal_volume
64pub_type
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