Metoclopramide decreases baroreflex sensitivity in patients with essential hypertension.

abstract：AIMS:With the purpose of exploring combinatorial options that could enhance the bactericide efficacy of linezolid against Gram-negative bacteria, we assessed the extent of combination of nano-silver and linezolid. MAIN METHODS:In this study, we selected Escherichia coli MTCC 443 as a model to study the combinatorial e...

journal_title：Life sciences

authors： Anuj SA,Gajera HP,Hirpara DG,Golakiya BA

更新日期：2019-08-01 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...

journal_title：Life sciences

authors： Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

更新日期：1984-05-07 00:00:00

abstract：:Corticotropin releasing factor (CRF), one of the major effectors of stress, plays a major role in the natural course of drug addiction by accelerating the acquisition of psychostimulant self-administration and increasing incentive motivation for the drug itself and for drug-associated stimuli. Stress-induced CRF is al...

journal_title：Life sciences

authors： Corominas M,Roncero C,Casas M

更新日期：2010-01-02 00:00:00

abstract：AIMS:To assess the relationship between endothelial dysfunction, endothelin 1 (ET-1) plasma levels and subclinical inflammation in primary open angle glaucoma (POAG) patients. MAIN METHODS:We enrolled 40 POAG patients with progressive visual field damage, although well controlled intraocular pressure (IOP) and compare...

journal_title：Life sciences

authors： Cellini M,Strobbe E,Gizzi C,Balducci N,Toschi PG,Campos EC

更新日期：2012-10-15 00:00:00

abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was d...

journal_title：Life sciences

authors： Margareto J,Aguado M,Osés-Prieto JA,Rivero I,Monge A,Aldana I,Marti A,Martínez JA

更新日期：2000-11-24 00:00:00

abstract：:In this study, we have identified the E-NTPDase family members and ecto-5'-nucleotidase/CD73 in rat heart left ventricle. Moreover, we characterize the biochemical properties and enzyme activities from synaptosomes of the nerve terminal endings of heart left ventricle. We observe divalent cation-dependent enzymes that...

journal_title：Life sciences

authors： Rücker B,Almeida ME,Libermann TA,Zerbini LF,Wink MR,Sarkis JJ

更新日期：2008-02-27 00:00:00

abstract：:Cardiovascular effects of the essential oil of Croton zehntneri (EOCZ) were investigated in conscious rats. In these preparations, intravenous (i.v.) injections of EOCZ (1-20 mg kg(-1)) and its main constituents anethole and estragole (both at 1-10 mg kg(-1)) elicited brief and dose-dependent hypotension and bradycard...

journal_title：Life sciences

authors： de Siqueira RJ,Magalhães PJ,Leal-Cardoso JH,Duarte GP,Lahlou S

更新日期：2006-04-11 00:00:00

abstract：:Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium-dependent calcium-stimulated adenosine triphosphatase ( ( Ca + Mg)-ATPase, EC 3.6.1.3.) of the red cell plasma membrane was not significantly changed. Maximal ...

journal_title：Life sciences

authors： Cameron BF,Green L

更新日期：1983-08-29 00:00:00

abstract：AIMS:Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. MAIN METH...

journal_title：Life sciences

authors： Lobato NS,Filgueira FP,Hagihara GN,Akamine EH,Pariz JR,Tostes RC,Carvalho MH,Fortes ZB

更新日期：2012-01-30 00:00:00

abstract：AIMS:Gastrointestinal cancers are a kind of deadly malignancy afflicting close to a million peoples worldwide. 5-Fluorouracil (5-Fu) is a main chemotherapeutic agent for cancer treatment. However, prolonged exposure of 5-Fu to cancer cells may cause chemoresistance and decrease the therapeutic potential of 5-Fu. MAIN ...

journal_title：Life sciences

authors： Zhu Y,Yi Y,Bai B,Li L,You T,Sun W,Yu Y

更新日期：2018-05-15 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO) directly infused into a brain-lateral ventricle (12.5, 25 and 50 micrograms/rat) dose- and time-dependently inhibited brain ODC activity. While having no influence per se on pain threshold, DFMO significantly inhibited the analgesic activity of morphine (15 mg/kg i.p.), this effect...

journal_title：Life sciences

authors： Genedani S,Bernardi M,Tagliavini S,Bertolini A

更新日期：1989-01-01 00:00:00

abstract：:The impact of exposure to lead on gut cytokine gene expression and oral tolerance was analyzed. Oral tolerization with ovalbumin (OVA) increased levels of IL-10 and TGF-beta in gut tissue while IFN-gamma mRNA levels remained unchanged in both autoimmune diabetes prone NOD and normal C57BL/6 mice. This shift towards Th...

journal_title：Life sciences

authors： Goebel C,Kirchhoff K,Wasmuth H,Flohé S,Elliott RB,Kolb H

更新日期：1999-01-01 00:00:00

abstract：:Changes in AMP-activated protein kinase (AMPK) activity contribute to the regulation of insulin secretion. Troglitazone has been shown to lower serum insulin levels and protect beta cell function. The aim of the present study was to examine the effects of troglitazone on AMPK activity and insulin secretion in beta cel...

journal_title：Life sciences

authors： Wang X,Zhou L,Shao L,Qian L,Fu X,Li G,Luo T,Gu Y,Li F,Li J,Zheng S,Luo M

更新日期：2007-06-20 00:00:00

abstract：:Inositol hexaphosphate (InsP6 or IP6) is ubiquitous. At 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) as well as inositol (Ins) are contained in most mammalian cells, wherein they are important in regulating vital cellular functions such as signal transduction, cell proliferation a...

journal_title：Life sciences

authors： Shamsuddin AM,Vucenik I,Cole KE

更新日期：1997-01-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP...

journal_title：Life sciences

authors： Fuzii HT,da Silva Dias GA,de Barros RJ,Falcão LF,Quaresma JA

更新日期：2014-05-28 00:00:00

abstract：:We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, an...

journal_title：Life sciences

authors： Crabbe JC,Kosobud A,Young ER

更新日期：1983-09-05 00:00:00

abstract：HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...

journal_title：Life sciences

authors： Yue J,Zhu T,Yang J,Si Y,Xu X,Fang Y,Fu W

更新日期：2020-07-15 00:00:00

abstract：AIMS:Acetylcholine (ACh) has been shown to increase ion and water excretion in the kidneys, resulting in hypotension. However, no evidence of renal parasympathetic innervation has been shown, and the source of ACh acting on nephrons is still unknown. The aim of the present study was to identify ACh-producing cells in t...

journal_title：Life sciences

authors： Maeda S,Jun JG,Kuwahara-Otani S,Tanaka K,Hayakawa T,Seki M

更新日期：2011-09-12 00:00:00

abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...

journal_title：Life sciences

authors： Miller KE,Brooks RR,Bonk KR,Carpenter JF

更新日期：1991-01-01 00:00:00

abstract：:The purpose of this study was to examine whether the adhesion of polymorphonuclear leukocytes (PMNs) to endothelial cells and/or reactive oxygen species (ROS) released from PMNs are responsible for inducing angiogenesis. Angiogenesis was assessed by tube formation using endothelial cells obtained from bovine thoracic ...

journal_title：Life sciences

authors： Yasuda M,Shimizu S,Tokuyama S,Watanabe T,Kiuchi Y,Yamamoto T

更新日期：2000-04-14 00:00:00

abstract：AIMS:We have developed biochemical and cell based assays to characterize small therapeutic molecules that inhibit the DNA damage checkpoint enzyme, Chk1 (Checkpoint kinase 1). MAIN METHODS:To prepare a screen of large chemical libraries, we purified the full-length and the catalytic domain versions of human Chk1. We c...

journal_title：Life sciences

authors： Ferry G,Studeny A,Bossard C,Kubara PM,Zeyer D,Renaud JP,Casara P,de Nanteuil G,Wierzbicki M,Pfeiffer B,Prudhomme M,Leonce S,Pierré A,Boutin JA,Golsteyn RM

更新日期：2011-08-15 00:00:00

abstract：:The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus in vitro has been investigated. Of the compounds tested, only trans-[(NO)(P(OEt)3)(NH3)4Ru](PF6)3 (1-2.5 mM) exerted a strong facilitatory action on the population spik...

journal_title：Life sciences

authors： Wieraszko A,Clarke MJ,Lang DR,Lopes LG,Franco DW

更新日期：2001-02-16 00:00:00

abstract：:Epinephrine (E) infusions raise blood pressure and there is an excess incidence of hypertension among males and blacks. However, reports of E levels by ethnicity, gender, and blood pressure status are inconsistent. Insensitive assays, variability in plasma E levels within individuals, and the small size of most studie...

journal_title：Life sciences

authors： González-Trápaga JL,Nelesen RA,Dimsdale JE,Mills PJ,Kennedy B,Parmer RJ,Ziegler MG

更新日期：2000-05-05 00:00:00

abstract：:Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA). Tyr metabolism has been studied in users of the new generation combined ...

journal_title：Life sciences

authors： Møller SE,Maach-Møller B,Olesen M,Madsen B,Madsen P,Fjalland B

更新日期：1995-01-01 00:00:00

abstract：AIMS:Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and red...

journal_title：Life sciences

authors： Khalilzadeh M,Abdollahi A,Abdolahi F,Abdolghaffari AH,Dehpour AR,Jazaeri F

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been found to contribute to the failure of ovarian carcinoma treatment. Oridonin is a natural en-kaurane tetracyclic diterpenoid compound discovered in Rabdosia rubescene (Henmsl.) Hara. Herein, we tested whether oridonin could exert chemo-sensitization activity on cisplatin-resistan...

journal_title：Life sciences

authors： Zhao Y,Xia H

更新日期：2019-09-15 00:00:00

abstract：AIMS:Clostridium difficile is an important pathogen in nosocomial infections. Although C. difficile toxins are considered to be major virulence factors, pathogenesis of C. difficile associated diseases remains to be determined. In this study, we investigated whether C. difficile flagellin is involved in the pathogenesi...

journal_title：Life sciences

authors： Yoshino Y,Kitazawa T,Ikeda M,Tatsuno K,Yanagimoto S,Okugawa S,Yotsuyanagi H,Ota Y

更新日期：2013-02-27 00:00:00

abstract：:The effect of anti beta adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after beta adrenoceptor blockade or after the absorption of...

journal_title：Life sciences

authors： Pascual J,Borda E,Sterin-Borda L

更新日期：1987-01-26 00:00:00

abstract：:alpha-lactorphin (Tyr-Gly-Leu-Phe) lowers blood pressure in conscious adult SHR. This tetrapeptide is originally released from milk protein alpha-lactalbumin by enzymatic hydrolysis. In order to evaluate the antihypertensive mechanisms of alpha-lactorphin, the effects of the tetrapeptide on vascular function were inve...

journal_title：Life sciences

authors： Sipola M,Finckenberg P,Vapaatalo H,Pihlanto-Leppälä A,Korhonen H,Korpela R,Nurminen ML

更新日期：2002-08-02 00:00:00