Abstract:
:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte associated beta-ir is authentic beta-endorphin (beta-EP) was confirmed by high performance liquid chromatography (HPLC). Analysis of blood samples from rabbits, rats and mice revealed the presence of beta-ir in erythrocytes from these species as well. These results suggest that there are two pools of beta-endorphin-like immunoreactivity in blood: plasma and erythrocytes.
journal_name
Life Scijournal_title
Life sciencesauthors
Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee ABdoi
10.1016/0024-3205(84)90677-5subject
Has Abstractpub_date
1984-05-07 00:00:00pages
1839-46issue
19eissn
0024-3205issn
1879-0631pii
0024-3205(84)90677-5journal_volume
34pub_type
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