Two pools of beta-endorphin-like immunoreactivity in blood: plasma and erythrocytes.

Abstract:

:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte associated beta-ir is authentic beta-endorphin (beta-EP) was confirmed by high performance liquid chromatography (HPLC). Analysis of blood samples from rabbits, rats and mice revealed the presence of beta-ir in erythrocytes from these species as well. These results suggest that there are two pools of beta-endorphin-like immunoreactivity in blood: plasma and erythrocytes.

journal_name

Life Sci

journal_title

Life sciences

authors

Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

doi

10.1016/0024-3205(84)90677-5

subject

Has Abstract

pub_date

1984-05-07 00:00:00

pages

1839-46

issue

19

eissn

0024-3205

issn

1879-0631

pii

0024-3205(84)90677-5

journal_volume

34

pub_type

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