Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP).

Abstract:

:Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP is the most common clinical manifestation of the virus. HAM/TSP is an inflammatory disease of the central nervous system (CNS); however, the mechanism by which HTLV-1 induces HAM/TSP is not yet clear. CD4(+) T lymphocytes are the main reservoirs of HTLV-1 in vivo and perform an important role in the immunological response to this retrovirus. This virus-host interaction may provoke changes in the immunological response, such as the enhanced production of inflammatory cytokines and the spontaneous proliferation of T CD4(+) lymphocytes, which are implicated in the pathogenesis of HAM/TSP.

journal_name

Life Sci

journal_title

Life sciences

authors

Fuzii HT,da Silva Dias GA,de Barros RJ,Falcão LF,Quaresma JA

doi

10.1016/j.lfs.2014.03.025

subject

Has Abstract

pub_date

2014-05-28 00:00:00

pages

9-14

issue

1-2

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(14)00366-X

journal_volume

104

pub_type

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