Abstract:
:Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP is the most common clinical manifestation of the virus. HAM/TSP is an inflammatory disease of the central nervous system (CNS); however, the mechanism by which HTLV-1 induces HAM/TSP is not yet clear. CD4(+) T lymphocytes are the main reservoirs of HTLV-1 in vivo and perform an important role in the immunological response to this retrovirus. This virus-host interaction may provoke changes in the immunological response, such as the enhanced production of inflammatory cytokines and the spontaneous proliferation of T CD4(+) lymphocytes, which are implicated in the pathogenesis of HAM/TSP.
journal_name
Life Scijournal_title
Life sciencesauthors
Fuzii HT,da Silva Dias GA,de Barros RJ,Falcão LF,Quaresma JAdoi
10.1016/j.lfs.2014.03.025subject
Has Abstractpub_date
2014-05-28 00:00:00pages
9-14issue
1-2eissn
0024-3205issn
1879-0631pii
S0024-3205(14)00366-Xjournal_volume
104pub_type
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