Oridonin elevates sensitivity of ovarian carcinoma cells to cisplatin via suppressing cisplatin-mediated autophagy.

abstract：AIMS:Endoplasmic reticulum stress (ERS) as an emerging factor is involved in insulin resistance (IR), which is the pathological basis of diabetes mellitus. Accumulation of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase is associated with IR, but the underlying mechanisms have not b...

journal_title：Life sciences

authors： Qiu N,Wei XM,Zhang ZJ,He YL,Zhou XK,Xiong Y

更新日期：2020-11-01 00:00:00

abstract：:The involvement of atriopeptin in hypertension was investigated in spontaneously hypertensive rats (SHR). It was found that intravenous injection of atriopeptin III (20-80 nmol/kg) markedly decreased the mean arterial pressure in anesthetized SHR in a dose dependent manner. The heart rate was not significantly affecte...

journal_title：Life sciences

authors： Xie CW,Song DL,Ding JF,Chang JK,Chang D,Tang J

更新日期：1986-03-17 00:00:00

abstract：:This investigation was designed to determine whether St. John's wort (SJW)(435 mg/kg/d), a readily available antidepressant, or its purported active constituents hypericin (1 mg/kg/d) and hyperforin (10 mg/kg/d) were able to induce various hepatic cytochrome P450 (CYP450) isoforms. SJW, hypericin and hyperforin were a...

journal_title：Life sciences

authors： Bray BJ,Brennan NJ,Perry NB,Menkes DB,Rosengren RJ

更新日期：2002-02-01 00:00:00

abstract：:Nitric oxide (NO) is generated from L-arginine by different isoforms of the enzyme nitric oxide synthase (NOS) and is known to be involved in mediating several biological functions, some of which are associated with reproduction. In this study, we examined the ability of the prepubertal ovary to express the inducible ...

journal_title：Life sciences

authors： Srivastava V,Jones BJ,Dookwah H,Hiney JK,Dees WL

更新日期：1997-01-01 00:00:00

abstract：:In this study we analyzed the N-formyl-Met-Leu-Phe (fMLP)-induced calcium signal in alveolar macrophages (AM) isolated from ovalbumin-sensitized (OA-sensitized AM) and naive (naive AM) guinea-pigs. Guinea-pigs were sensitized by subcutaneous injection of OA and AM were isolated by bronchoalveolar lavage 6 weeks therea...

journal_title：Life sciences

authors： Failli P,Bindi D,Franceschelli F,Tanini A,Ciuffi M,Mazzetti L,Zilletti L

更新日期：2001-08-24 00:00:00

abstract：AIMS:To potentiate the well-documented tumor protecting ability of paullones, literatures demand for rational modifications in paullone ring structure and exploration of a precise mechanism underlying their antitumor effects. Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-...

journal_title：Life sciences

authors： Singh AK,Bhadauria AS,Kumar U,Raj V,Maurya V,Kumar D,Maity B,Prakash A,De A,Samanta A,Saha S

更新日期：2018-05-15 00:00:00

abstract：:The subcellular distribution of Gamma-aminobutyric acid (GABA) was studied in the rat oviduct. The highest content of GABA was found in the soluble fraction. The effect of chemical stimulation of the endogenous GABA efflux from the rat oviduct was examined. High K+ concentrations could not induce elevation of the GABA...

journal_title：Life sciences

authors： Forray MI,Hidalgo P,Díaz F,Belmar J

更新日期：1993-01-01 00:00:00

abstract：:Definition of the physiological and pharmacological properties of primary afferent neurons by the use of capsaicin and its analogues (e.g. resiniferatoxin) has represented one of the most active areas of research of the last decade (1-4 for reviews). In the past 3 years many important advancements have been made in th...

journal_title：Life sciences

authors： Amann R,Maggi CA

更新日期：1991-01-01 00:00:00

abstract：:The flavonoid quercetin exhibited a biphasic effect on calcium and phospholipid-dependent protein kinase (protein kinase C) activity from rat brain and pig thyroid. At a low concentration (10(-7) M) quercetin stimulated the enzyme activity whereas at higher concentrations quercetin was inhibitory. By contrast the synt...

journal_title：Life sciences

authors： Picq M,Dubois M,Munari-Silem Y,Prigent AF,Pacheco H

更新日期：1989-01-01 00:00:00

abstract：:Nitric oxide (NO) plays a critical role in the pathogenesis of endotoxin-induced uveitis (EIU). Since NO is a labile free radical, it is difficult to examine the dynamics of NO directly in vivo. In this study, we established a system for direct monitoring of the dynamics of NO and partial pressure of oxygen (pO(2)) in...

journal_title：Life sciences

authors： Yomura Y,Shoji Y,Asai D,Murakami E,Ueno S,Nakashima H

更新日期：2007-03-27 00:00:00

abstract：:Prolidase deficiency seems to be a rather rare metabolic disorder. However, many new cases can be detected because screening is easy to perform and enzymatic confirmation allows the differentiation from other iminodipeptidurias . Clinical symptoms are briefly reviewed, while biological considerations and prolidase pro...

journal_title：Life sciences

authors： Myara I,Charpentier C,Lemonnier A

更新日期：1984-05-21 00:00:00

abstract：OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...

journal_title：Life sciences

authors： Ma Z,Dong Q,Lyu B,Wang J,Quan Y,Gong S

更新日期：2019-02-01 00:00:00

abstract：:The effect of polyamines on the catalytic domain of protein kinase C from rat brain was investigated. It was found that the addition of spermine strongly inhibited phosphorylation activity toward histone H1 as substrate. This tetramine, at millimolar concentrations, was most potently effective while triamines and diam...

journal_title：Life sciences

authors： Mezzetti G,Monti MG,Moruzzi MS

更新日期：1988-01-01 00:00:00

abstract：AIMS:Transforming growth factor-β1 (TGF-β1) plays a significant role in epithelial-mesenchymal transition (EMT). Furthermore, endoplasmic reticulum (ER) stress also can induce EMT. However, the relationship among TGF-β1, ER stress and EMT in podocytes is still unclear. Consequently, this study examines the crosstalk ef...

journal_title：Life sciences

authors： Chen CA,Chang JM,Chang EE,Chen HC,Yang YL

更新日期：2018-09-15 00:00:00

abstract：:Pretreatment of pancreatic acini with 5-hydroxytryptamine (5-HT) reduced the binding of the labeled somatostatin (SS) analogue 125I-Tyr3-SMS to pancreatic acinar membranes. This effect was dependent of the dose of 5-HT used and length of pretreatment. This inhibitory effect of 5-HT was abolished when pancreatic acini ...

journal_title：Life sciences

authors： Muñoz-Acedo G,Rodríguez-Martin E,Puebla L,Arilla E

更新日期：1997-01-01 00:00:00

abstract：:The cellular electrophysiology of left ventricular preparations from guinea pig hearts was studied 1 hour, 24 hours, and 4-6 weeks after myocardial infarction produced by 6-8 single ties of the distal left coronary artery system or after sham operation. Microelectrode recordings were used to monitor cells from the end...

journal_title：Life sciences

authors： Gaide MS,Cameron JS,Altman CB,Myerburg RJ,Bassett AL

更新日期：1985-06-24 00:00:00

abstract：:Bromopride (BRO) and domperidone (DOMP) are dopamine D2 blocking agents used in gastroenterology clinics because of their anti emetic effect as well as their central and peripheral actions of increasing gastrointestinal motor activity. The rationale for these experiments was to compare BRO- and DOMP-effects on plasma,...

journal_title：Life sciences

authors： Nasello AG,Gidali D,de Sá-Rocha LC,Felicio LF

更新日期：1995-01-01 00:00:00

abstract：:A laboratory mouse can be partially restrained by placing it inside a cage with its tail protruding through a hole in one wall and taped to a surface outside of the cage. The mouse maintains enough mobility to perform an operant response yet its movements are limited to the extent that electrical or chemical stimulati...

journal_title：Life sciences

authors： Criswell HE

更新日期：1982-11-15 00:00:00

abstract：:Thalidomide (Thd) was given in two trials (total daily dose: 5 or 8 mg Thd/kg body weight, respectively) for five and three days to a healthy male volunteer, and various receptors were analyzed on white blood cells before, during and after (up to 30 days) the treatment period. There were neither marked deviations in t...

journal_title：Life sciences

authors： Neubert R,Nogueira AC,Neubert D

更新日期：1992-01-01 00:00:00

abstract：:Recent studies suggest that protein kinase C and, thus, possibly the rate of inositol phospholipid hydrolysis may regulate the function and distribution of the asialoglycoprotein (or galactosyl) receptor on isolated rat hepatocytes (Takahashi et al., Biochem. Biophys. Res. Commun., 1985, 126, 1054; Fallon and Schwartz...

journal_title：Life sciences

authors： Medh JD,Haynes PA,Weigel PH,LaBelle EF

更新日期：1989-01-01 00:00:00

abstract：AIMS:DNA methylation and hydroxymethylation are significantly related to the occurrence and development of coronary heart disease (CHD) and atherosclerosis (AS). 5-Methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) are used to assess DNA methylation and hydroxymethylation levels, respectively. However, 5-mC and ...

journal_title：Life sciences

authors： Jiang D,Sun M,You L,Lu K,Gao L,Hu C,Wu S,Chang G,Tao H,Zhang D

更新日期：2019-05-01 00:00:00

abstract：:Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...

journal_title：Life sciences

authors： Osadchii O,Woodiwiss A,Alves N,Norton G

更新日期：2005-12-12 00:00:00

abstract：:Ro 15-1788 (10 mg/kg, ip) and CGS 8216 (10 mg/kg, ip) significantly reversed the inhibitory effect of diazepam (5 mg/kg, ip) on electrically induced head-turning in rats. Neither antagonist alone, at the dose level which blocked diazepam, had any intrinsic activity in this model. The specificity of the interaction bet...

journal_title：Life sciences

authors： Goldstein JM,Sutton EB,Malick JB

更新日期：1986-02-03 00:00:00

abstract：:Cilostazol(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone) selectively inhibits cGMP-inhibited phosphodiesterase (PDE3) and is a potent inhibitor of platelet aggregation induced by various agonists. Effect of cilostazol on shear stress-induced human platelet aggregation (SIPA) was examined...

journal_title：Life sciences

authors： Minami N,Suzuki Y,Yamamoto M,Kihira H,Imai E,Wada H,Kimura Y,Ikeda Y,Shiku H,Nishikawa M

更新日期：1997-01-01 00:00:00

abstract：AIM:To compare embryonic developmental competence and clinical outcomes of oocytes matured in vivo (IVF oocytes) and those matured in vitro (IVM oocytes) from the same IVM/IVF cycles, and to analyze the clinical efficiency of a melatonin-supplemented in vitro maturation system combined with a modified IVM/IVF protocol....

journal_title：Life sciences

authors： Li X,Mu Y,Elshewy N,Ding D,Zou H,Chen B,Chen C,Wei Z,Cao Y,Zhou P,Zhang Z

更新日期：2021-01-01 00:00:00

abstract：:The retina contains three catecholamine neurotransmitters: dopamine (DA); norepinephrine (NE); and epinephrine (EPI). DA and EPI appear to be associated with separate amacrine neurons that directly participate in the visual process. NE, in contrast, appears to be associated primarily with the sympathetic nerves that i...

journal_title：Life sciences

authors： Hadjiconstantinou M,Neff NH

更新日期：1984-09-10 00:00:00

abstract：:Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...

journal_title：Life sciences

authors： Pan H,Zhao F,Yang Y,Chang N

更新日期：2020-08-01 00:00:00

abstract：:The potential role of exercise in preventing the age-related spontaneous peripheral neuropathy has not been studied. We examined the effects of long-term aerobic exercise training on lipid peroxidation, Schwann cell (SC) apoptosis and ultrastructural changes in the sciatic nerve of rats during aging. Three groups of 1...

journal_title：Life sciences

authors： Shokouhi G,Tubbs RS,Shoja MM,Roshangar L,Mesgari M,Ghorbanihaghjo A,Ahmadi N,Sheikhzadeh F,Rad JS

更新日期：2008-04-09 00:00:00

abstract：AIMS:Prior work suggests that ischemic preconditioning increases the level of CD39 in the heart and contributes to cardiac protection. Therefore, we examined if targeted cardiac expression of CD39 protects against myocardial injury. MAIN METHODS:Mice with cardiac-specific expression of human CD39 (αMHC/hCD39-Tg) were ...

journal_title：Life sciences

authors： Smith SB,Xu Z,Novitskaya T,Zhang B,Chepurko E,Pu XA,Wheeler DG,Ziolo M,Gumina RJ

更新日期：2017-06-15 00:00:00

abstract：:Matrikines, peptides originating from the fragmentation of extracellular matrix proteins are identified to play important role in both health and disease. They possess biological activities, much different from their parent protein. Identification of such bioactive cryptic regions in the extracellular matrix proteins ...

journal_title：Life sciences

authors： Sivaraman K,Shanthi C

更新日期：2018-12-01 00:00:00