Ovalbumin sensitization of guinea-pigs reduces fMLP-induced calcium signal in alveolar macrophages.

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：:CGS 10746B, a benzothiadiazepine, has a behavioral profile in mice and monkeys similar to the atypical antipsychotic clozapine. Unlike clozapine, CGS 10746B suppresses dopamine neuron firing rates and, when administered at behaviorally effective doses by the oral or intraperitoneal route, decreases neostriatal dopamin...

journal_title：Life sciences

authors： Altar CA,Wasley AM,Liebman J,Gerhardt S,Kim H,Welch JJ,Wood PL

更新日期：1986-08-25 00:00:00

abstract：:DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are ...

journal_title：Life sciences

authors： Zhou Q,You C,Zheng C,Gu Y,Gu H,Zhang R,Wu H,Sun B

更新日期：2018-08-01 00:00:00

abstract：AIMS:To examine the role of trypsin in the immune response of macrophages and to determine whether protease-activated receptors (PARs) are involved in the effects of trypsin. MAIN METHODS:We used RAW264.7 cells and peritoneal macrophages isolated from C57BL/6 wild-type mice, PAR2 knockout mice, and ddY mice. Macrophag...

journal_title：Life sciences

authors： Komatsu H,Shimose A,Shimizu T,Mukai Y,Kobayashi J,Ohama T,Sato K

更新日期：2012-08-21 00:00:00

abstract：:Nitric oxide (NO) is generated from L-arginine by different isoforms of the enzyme nitric oxide synthase (NOS) and is known to be involved in mediating several biological functions, some of which are associated with reproduction. In this study, we examined the ability of the prepubertal ovary to express the inducible ...

journal_title：Life sciences

authors： Srivastava V,Jones BJ,Dookwah H,Hiney JK,Dees WL

更新日期：1997-01-01 00:00:00

abstract：:In order to investigate the action of ethanol on the anterior pituitary gland, the effect of ethanol on prolactin secretion in vitro was studied. Ethanol significantly increased the in vitro incorporation of 3H-leucine into both prolactin contained within the pituitary gland and that released into the medium. The enha...

journal_title：Life sciences

authors： Seilicovich A,Duvilanski BH,Debeljuk L,Díaz MC,Muñoz Maines V,Rettori V

更新日期：1984-11-05 00:00:00

abstract：:The study was designed to investigate the role of molybdenum iron-sulfur flavin hydroxylases in the pathogenesis of liver injuries induced by structurally and mechanistically diverse hepatotoxicants. While carbon tetrachloride (CCl4), thioacetamide (TAA) and chloroform (CHCl3) inflict liver damage by producing free ra...

journal_title：Life sciences

authors： Ali S,Pawa S,Naime M,Prasad R,Ahmad T,Farooqui H,Zafar H

更新日期：2008-03-26 00:00:00

abstract：:The purpose of this study was to determine the effects of the 7288ctc Morris hepatoma on heart size and performance. Hearts from tumor bearing and control animals were perfused in the working configuration one to three weeks post implantation. As tumor growth progressed there was an inverse linear relationship between...

journal_title：Life sciences

authors： Broussard HJ,Lang C,Burns AH

更新日期：1994-01-01 00:00:00

abstract：:The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...

journal_title：Life sciences

authors： Lam EKY,Tai EKK,Koo MWL,Wong HPS,Wu WKK,Yu L,So WHL,Woo PCY,Cho CH

更新日期：2007-05-16 00:00:00

abstract：AIMS:Second-generation antipsychotic drugs (SGAs) have a high risk for serious metabolic side-effects including dyslipidemia. This study aimed to investigate the acute effects of oral olanzapine treatment on the expression of genes for fatty acid and cholesterol biosynthesis in rats. MAIN METHODS:Female Sprague-Dawley...

journal_title：Life sciences

authors： Liu X,Deng C,Cao S,Gong J,Wang BC,Hu CH

更新日期：2015-05-01 00:00:00

abstract：:A new indorocarbazole antibiotic SF2370 has been found in the culture broth of Actinomadura sp.; it has also been found to have the activities of antihypertension and diuresis. Derivatives of SF2370, NA0344, NA0345 and NA0346, when injected (0.1-1 mg/kg i.v.) significantly lowered the blood pressure of anesthetized no...

journal_title：Life sciences

authors： Hachisu M,Hiranuma T,Koyama M,Sezaki M

更新日期：1989-01-01 00:00:00

abstract：:Angiogenesis-targeted therapy of cancer is considered a promising strategy for therapeutic management of cancer progression. Over the last two decades, a few anti-angiogenesis monoclonal antibodies (mAbs) blocking VEGF signaling have been developed and approved by the FDA. The most widely used anti-angiogenesis drug i...

journal_title：Life sciences

authors： Fallah A,Heidari HR,Bradaran B,Sisakht MM,Zeinali S,Molavi O

更新日期：2019-12-15 00:00:00

abstract：AIM:The present study aimed to understand the relationship between pharmacological activation of mGlu4 receptors and regulation of its gene in the hippocampus. MAIN METHODS:The expression level of the GRM4 gene, encoding mGluR4 receptors, was studied in the hippocampus and frontal cortex of rats after pharmacological ...

journal_title：Life sciences

authors： Pershina EV,Arkhipov VI

更新日期：2016-05-15 00:00:00

abstract：AIMS:Tetramethylpyrazine (TMP), one of the active ingredients isolated from a Chinese herbal prescription, possesses protective effects against oxidative stress caused by high glucose in endothelial cells. In this study, the role of TMP in preventing muscle cells from palmitate-induced oxidative damage was investigated...

journal_title：Life sciences

authors： Gao X,Zhao XL,Zhu YH,Li XM,Xu Q,Lin HD,Wang MW

更新日期：2011-04-25 00:00:00

abstract：:Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...

journal_title：Life sciences

authors： Moreira RS,Bicker J,Musicco F,Persichetti A,Pereira AMPT

更新日期：2020-01-01 00:00:00

abstract：:The effect of local pH on the in vivo efflux of endogenous dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) following administration of d-amphetamine (AMPH) was examined in the striatum of the anesthetized rat using two bilaterally placed push-pull cannulae. At both pH 7.3 and 6.4, the baseline efflux values f...

journal_title：Life sciences

authors： Guan XM,McBride WJ

更新日期：1988-01-01 00:00:00

abstract：:The opioid peptides [Met] enkephalin-Arg6-Phe7, [Met]-enkephalin-Arg6-Gly7-Leu8, and BAM-12P were identified in various ares of human brain by use of a combination of radioimmunoassay (RIA), gel filtration, and high performance liquid chromatography (HPLC). The highest levels of each peptide were found in striatum, fo...

journal_title：Life sciences

authors： Pittius CW,Seizinger BR,Mehraein P,Pasi A,Herz A

更新日期：1983-01-01 00:00:00

abstract：:Neurotensin (NT) administered intracerebroventricularly (i.c.v.) to rats, blocks intestinal transit (tested by charcoal meal) in linear relation to the log of the doses within the range of 0.6-2.5 nmoles/rat. NT in this test is about 40 times more active than morphine (M) and 6 times less active than dermorphin (DM) o...

journal_title：Life sciences

authors： Parolaro D,Sala M,Crema G,Spazzi L,Gori E

更新日期：1983-01-01 00:00:00

abstract：AIMS:Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the eff...

journal_title：Life sciences

authors： Lacy RT,Strickland JC,Brophy MK,Witte MA,Smith MA

更新日期：2014-10-02 00:00:00

abstract：:The biosynthesis of phospholipids during differentiation of normal and dystrophic muscle cells was studied using [32Pi] added to primary culture media. Labeled phosphatides were separated by two-dimensional thin-layer chromatography, exposing the plates to HCl vapors between solvents to cleave the alk-1-enyl bonds. Ph...

journal_title：Life sciences

authors： Leskawa KC,Erwin RE,Hogan EL

更新日期：1986-01-13 00:00:00

abstract：AIMS:Hepatocyte growth factor (HGF) modulates intestinal epithelial cell proliferation and migration. We previously reported that systemic administration of recombinant human HGF (rh-HGF) ameliorated experimental colitis. However, an increase in serum HGF concentrations may induce undesired systemic effects, limiting t...

journal_title：Life sciences

authors： Setoyama H,Ido A,Numata M,Moriuchi A,Yamaji N,Tamai T,Funakawa K,Fujita H,Sakiyama T,Uto H,Oketani M,Tsubouchi H

更新日期：2011-08-15 00:00:00

abstract：:Bufalin, which is one of prominent components of Chinese toad venom, was found to decrease the rate of cell proliferation of mouse melanoma clone B16-F10 cells and a concomitant stimulation of expression of its melanotic phenotype. The effect of bufalin on melanogenesis included stimulation of tyrosinase activity and ...

journal_title：Life sciences

authors： Zhang L,Yoshida T,Kuroiwa Y

更新日期：1992-01-01 00:00:00

abstract：:Plasma 7B2-immunoreactivity (7B2-IR) concentrations in umbilical artery (UA), umbilical vein (UV) and maternal vein (MV) were measured by RIA at the time of obstetrical delivery at term. Plasma 7B2-IR concentrations (Mean +/- SEM) in UA (N = 12), UV (N = 16) and MV (N = 16) were 725 +/- 69, 699 +/- 64 and 116 +/- 4.5 ...

journal_title：Life sciences

authors： Iguchi H,Natori S,Nawata H,Kato K,Ibayashi H,Chan JS,Seidah NG,Chretien M

更新日期：1987-10-19 00:00:00

abstract：:Doxorubicin and daunorubicin, the anthracycline antitumor agents, were evaluated for their in vitro and in vivo effect on phosphodiesterase (PDE) activity in mouse tissues. Doxorubicin at a concentration of 10(-4)M inhibited cardiac c-AMP (adenosine 3',5', monophosphate) PDE activity 50% of the control whereas in lung...

journal_title：Life sciences

authors： Law J,Fumagalli A,Schein PS,Rahman A

更新日期：1985-02-11 00:00:00

abstract：:More than 140 thousands of women suffer from endometrial carcinoma in the worldwide, and over 40 thousand of the patients die before and after in surgery and chemoradiotherapy because of its metastasis. However, its molecular mechanism is much less known compared to other cancers. In this study, we demonstrated that l...

journal_title：Life sciences

authors： Zhang C,Shao S,Zhang Y,Wang L,Liu J,Fang F,Li P,Wang B

更新日期：2020-02-15 00:00:00

abstract：:Benzodiazepines reliably produce overconsumption of food and fluids. Opiate antagonists, naloxone and naltrexone, block the benzodiazepine-induced hyperphagia and hyperdipsia at low doses. Hence, activation of endogenous opioid mechanisms may be closely involved in the benzodiazepine facilitatory effects on ingestiona...

journal_title：Life sciences

authors： Cooper SJ

更新日期：1983-03-07 00:00:00

abstract：:Although several reports imply that anticoagulants and preservatives contain zinc, the quantity of zinc in heparin, if any, has not been documented. Zinc concentration was determined by flame atomic absorption spectroscopy in varying dilutions of multiple commercially obtained samples of purified sodium heparin N = 15...

journal_title：Life sciences

authors： Gervin CA,Gervin AS,Nichols W,Corrigan JJ Jr

更新日期：1983-12-26 00:00:00

abstract：:Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better ...

journal_title：Life sciences

authors： Yi LT,Li JM,Li YC,Pan Y,Xu Q,Kong LD

更新日期：2008-03-26 00:00:00

abstract：:Dose-effect curves were obtained for five specific components of stereotyped behavior (locomotor hyperactivity, rearing, sniffing, grooming and oral activity) elicited by the nonselective dopamine agonists N-propylnorapomorphine (NPA; 0.001-4.5 mg/kg) and apomorphine (APO; 0.3-10.0 mg/kg), the selective D2 agonists LY...

journal_title：Life sciences

authors： Meller E,Bordi F,Bohmaker K

更新日期：1988-01-01 00:00:00

abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...

journal_title：Life sciences

authors： Graham D,Langer SZ

更新日期：1992-01-01 00:00:00