Minireview. Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behavior.

Abstract:

:Benzodiazepines reliably produce overconsumption of food and fluids. Opiate antagonists, naloxone and naltrexone, block the benzodiazepine-induced hyperphagia and hyperdipsia at low doses. Hence, activation of endogenous opioid mechanisms may be closely involved in the benzodiazepine facilitatory effects on ingestional behavior. Evidence is reviewed that opiate antagonists diminish feeding and drinking responses, and may enhance satiety processes in feeding and drinking, in addition to selectively diminishing the palatability of attractive foods and fluids. It is proposed that a single mechanism of action of the opiate antagonists would be sufficient to account for both effects on feeding and drinking. Biochemical data confirm that acute benzodiazepine treatment in vivo is associated with a naloxone-reversible release of striatal enkephalin. It is possible therefore that there is a close association between the behavioral and biochemical data, which both show that acute benzodiazepine effects are reversed by opiate antagonists. The implied relationship between benzodiazepine and endogenous opioid mechanisms may be relevant to the question of concurrent opiate-benzodiazepine abuse.

journal_name

Life Sci

journal_title

Life sciences

authors

Cooper SJ

doi

10.1016/0024-3205(83)90108-x

subject

Has Abstract

pub_date

1983-03-07 00:00:00

pages

1043-51

issue

10

eissn

0024-3205

issn

1879-0631

pii

0024-3205(83)90108-X

journal_volume

32

pub_type

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