Abstract:
:Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better understand its pharmacological activity, we investigated the behavioral effects of chronic oral apigenin treatment in the FST in male ICR mice and male Wistar rats exposed to chronic mild stress (CMS). The effects of apigenin on central monoaminergic neurotransmitter systems, the hypothalamic-pituitary-adrenal (HPA) axis and platelet adenylyl cyclase activity were simultaneously examined in the CMS rats. Apigenin reduced immobility time in the mouse FST and reversed CMS-induced decrease in sucrose intake of rats. Apigenin also attenuated CMS-induced alterations in serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) levels and 5-HIAA/5-HT ratio in distinct rat brain regions. Moreover, apigenin reversed CMS-induced elevation in serum corticosterone concentrations and reduction in platelet adenylyl cyclase activity in rats. These results suggest that the antidepressant-like actions of oral apigenin treatment could be related to a combination of multiple biochemical effects, and might help to elucidate its mechanisms of action that are involved in normalization of stress-induced changes in brain monoamine levels, the HPA axis, and the platelet adenylyl cyclase activity.
journal_name
Life Scijournal_title
Life sciencesauthors
Yi LT,Li JM,Li YC,Pan Y,Xu Q,Kong LDdoi
10.1016/j.lfs.2008.01.007subject
Has Abstractpub_date
2008-03-26 00:00:00pages
741-51issue
13-14eissn
0024-3205issn
1879-0631pii
S0024-3205(08)00037-4journal_volume
82pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, was administered orally for 12 weeks to male rats with prednisolone-induced osteoporosis. Microdensitometric analysis of a roentgenograph of the femurs revealed that ipriflavone increased the density of the distal metaphysis dose-dependently and tended to incre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90265-1
更新日期:1986-03-10 00:00:00
abstract::Respiring mitochondria represent the major source of superoxide production in most cells, and superoxide anions function as direct precursors of hydrogen peroxide formation within mitochondria. We use a lucigenen-derived chemiluminescence (LDCL) assay to test the hypothesis that intramitochondrial superoxide productio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01538-2
更新日期:2002-05-03 00:00:00
abstract:AIMS:The aim of this study was to find out a mesenchymal stem cells (MSCs) source from human dental tissues of the same donor (follicle, papilla and pulp), which exhibits higher neurogenic differentiation potential in vitro. MAIN METHODS:MSCs were isolated from dental tissues (follicle, papilla and pulp) by digestion ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.04.026
更新日期:2016-06-01 00:00:00
abstract::Clinical studies of cholinergic pharmacotherapy, together with the putative role of the muscarinic receptor system in the neurophysiology of human behavior, support a possible muscarinic cholinergic involvement in schizophrenia. The present study has measured the density of [3H]AF-DX 384 labelled receptors (muscarinic...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00114-9
更新日期:1999-01-01 00:00:00
abstract::Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2) was most strongly affected (50% inhibition at 3 mM phenobarbital); p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90530-3
更新日期:1987-11-02 00:00:00
abstract::The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compou...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2013.12.011
更新日期:2014-01-30 00:00:00
abstract::The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.02.004
更新日期:2006-07-04 00:00:00
abstract:AIM:Pancreatic stellate cells (PSCs) are the main functional cells leading to pancreatic fibrosis. Nicotine is widely considered as an independent risk factor of pancreatic fibrosis, but the mechanism is still unclear. Our study was aimed to explore the effects of nicotine on human pancreatic stellate cells (hPSCs) and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117301
更新日期:2020-02-15 00:00:00
abstract::Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melano...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90501-8
更新日期:1989-01-01 00:00:00
abstract::The tendency to associate a given response-reinforcement combination reflects the adaptive significance of the association. Biologically relevant reinforcement can be much more effective in modifying certain responses. For example, treatments that result in various types of illness readily condition aversions to novel...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90571-7
更新日期:1989-01-01 00:00:00
abstract::The role of extracellular acidosis in inflammatory airway diseases is not well known. One consequence of tissue acidification is the stimulation of sensory nerves via the polymodal H(+)-gated transmembrane channels ASICs and TRPV1 receptor. The present study investigated the effect of acidosis on airway basal tone and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.08.026
更新日期:2007-09-08 00:00:00
abstract::We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90751-8
更新日期:1983-09-05 00:00:00
abstract::Somatostatin (SS) acts as a universal endocrine off-swich, and also inhibits the growth of neuroendocrine tumors through its specific receptors. Small cell lung cancer (SCLC) demonstrates some neuroendocrine characteristics and has been proposed as a candidate for treatment with SS and its analogues. In the present st...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90090-6
更新日期:1994-01-01 00:00:00
abstract:AIMS:The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by melatonin and serotonin. Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic agonist and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.04.035
更新日期:2016-06-15 00:00:00
abstract::Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02169-0
更新日期:2002-11-08 00:00:00
abstract::This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90495-x
更新日期:1988-01-01 00:00:00
abstract:AIM:Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.03.011
更新日期:2017-05-01 00:00:00
abstract:AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.01.003
更新日期:2013-03-28 00:00:00
abstract::Tramadol is a clinically-effective, centrally-acting analgesic. This drug is a racemic mixture of two enantiomers, each one displaying different mechanisms: (+)tramadol displays opioid agonist properties and inhibits serotonin reuptake while (-)tramadol inhibit preferentially noradrenaline reuptake. The action of tram...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00369-5
更新日期:1998-01-01 00:00:00
abstract::The mammalian pineal gland synthesizes melatonin in a circadian manner, peaking during the dark phase. This synthesis is primarily regulated by sympathetic innervations via noradrenergic fibers, but is also modulated by many peptidergic and hormonal systems. A growing number of studies reveal a complex role for melato...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.10.016
更新日期:2008-01-02 00:00:00
abstract::Progressive lysis of bone in loose total hip replacement has been ascribed to the capacity of the synovial-like membrane present at the bone interface to produce prostaglandin E2 and cytokines such as tumor necrosis factor (TNF alpha). Phospholipase A2 (PLA2) produces rate limiting precursor i.e. arachidonic acid in t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00342-6
更新日期:1996-01-01 00:00:00
abstract:AIMS:Prior work suggests that ischemic preconditioning increases the level of CD39 in the heart and contributes to cardiac protection. Therefore, we examined if targeted cardiac expression of CD39 protects against myocardial injury. MAIN METHODS:Mice with cardiac-specific expression of human CD39 (αMHC/hCD39-Tg) were ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.10.016
更新日期:2017-06-15 00:00:00
abstract::In this study, we have focused our investigation of the facts whether co-administration of a NMDA antagonist dextromethorphan (DM) with morphine during pregnancy and throughout lactation could prevent the adverse effects associated with chronic morphine administration in rat offspring. Adult female Sprague-Dawley rats...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01316-9
更新日期:2001-10-05 00:00:00
abstract::P120-catenin (P120) was known to function in adhesion between cells and signal transduction in many types of cells. In this study, we investigated the expression and role of P120 in pulmonary fibrosis and transforming growth factor beta (TGF-β) mediated lung fibroblast-to-myofibroblast differentiation (fibroblast diff...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.05.052
更新日期:2019-08-01 00:00:00
abstract::Imidazole (IMI) (from 18.7 to 300 mg/Kg) i.p. injected in adult rats induced shaking, which was antagonized by both morphine (MOR) and haloperidol (HALO) but not by methysergide (MET). I.p. IMI pretreatment inhibited the penile erections (PE) and stretching and yawning (SY) typically elicited by N-n-propylnorapomorphi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90046-3
更新日期:1985-04-08 00:00:00
abstract::The effect of adrenergic agents on protein phosphorylation in human adipocytes was examined. Freshly isolated human fat cells were incubated with 32PO4 in order to label intracellular ATP, then treated with a variety of adrenergic and other pharmacologic agents. Treatment with the beta-adrenergic agonist isoproterenol...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90597-k
更新日期:1990-01-01 00:00:00
abstract:AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.03.022
更新日期:2014-05-08 00:00:00
abstract:AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.11.018
更新日期:2016-01-01 00:00:00
abstract::The present experiment was designed to determine whether scavenging capacity of serum, in addition to glucose level, influences hemoglobin and serum protein glycosylation in non-insulin dependent diabetic patients. For this purpose forty-seven patients homogeneous for age, disease duration, therapy and glyco-metabolic...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00256-1
更新日期:1996-01-01 00:00:00
abstract::Efonidipine is a dihydropyridine Ca2+ antagonist with inhibitory effects on both L-type and T-type Ca2+ channels and potent bradycardiac activity especially in patients with high heart rate. In the present study, we examined the frequency dependence of efonidipine action on the T-type Ca2+ channel in isolated guinea-p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00932-2
更新日期:2000-12-08 00:00:00