Thalidomide and the immune system. 2. Changes in receptors on blood cells of a healthy volunteer.

abstract：:Intrathecal (i.t.) injection (between lumbar vertebrae 5 and 6) into mice of a markedly low dose of IL-1alpha (3x10(-4) fmol or 5.4 fg in 5 microl per mouse) induced behaviors involving scratching, biting, and licking of non-stimulated hindpaws. The IL-1-induced behaviors appeared within 10 min of the injection of IL-...

journal_title：Life sciences

authors： Tadano T,Namioka M,Nakagawasai O,Tan-No K,Matsushima K,Endo Y,Kisara K

更新日期：1999-01-01 00:00:00

abstract：:alpha-lactorphin (Tyr-Gly-Leu-Phe) lowers blood pressure in conscious adult SHR. This tetrapeptide is originally released from milk protein alpha-lactalbumin by enzymatic hydrolysis. In order to evaluate the antihypertensive mechanisms of alpha-lactorphin, the effects of the tetrapeptide on vascular function were inve...

journal_title：Life sciences

authors： Sipola M,Finckenberg P,Vapaatalo H,Pihlanto-Leppälä A,Korhonen H,Korpela R,Nurminen ML

更新日期：2002-08-02 00:00:00

abstract：AIMS:Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, an...

journal_title：Life sciences

authors： Li X,Guo Y,Kuang X,Zhao L,Li H,Cheng B,Wang W,Zhang Z,Liu P,Wang J

更新日期：2019-04-15 00:00:00

abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

journal_title：Life sciences

authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

更新日期：1997-01-01 00:00:00

abstract：:In critically ill patients various conditions may lead to the activation of poly(ADP-ribose) polymerase (PARP). By promoting cellular energetic dysfunction, and by enhancing pro-inflammatory gene expression, PARP activation significantly contributes to the pathogenesis of shock. PARP activation is usually triggered by...

journal_title：Life sciences

authors： Horváth EM,Benko R,Gero D,Kiss L,Szabó C

更新日期：2008-01-16 00:00:00

abstract：AIM:The purpose of this study was to investigate whether the flavonoid quercetin can prevent alterations in the behavioral tests and of cholinergic neurotransmission in rats submitted to the ethidium bromide (EB) experimental demyelination model during events of demyelination and remyelination. MAIN METHODS:Wistar rat...

journal_title：Life sciences

authors： Beckmann DV,Carvalho FB,Mazzanti CM,Dos Santos RP,Andrades AO,Aiello G,Rippilinger A,Graça DL,Abdalla FH,Oliveira LS,Gutierres JM,Schetinger MR,Mazzanti A

更新日期：2014-05-17 00:00:00

abstract：:The conversion of beta-carotene to retinal and the succeeding metabolic process of the retinal leading to production of retinol and retinyl esters are the prerequisite for the utilization of beta-carotene as a provitamin A. These processes are participated by beta-carotene cleavage enzyme, retinal reductase and retino...

journal_title：Life sciences

authors： Tajima S,Goda T,Takase S

更新日期：1999-01-01 00:00:00

abstract：AIMS:Insulinoma-associated protein 2β (IA-2β) is considered to play a significant role in regulated secretion. Recent studies have shown that the mouse brain expresses three major isoforms of IA-2β, named IA-2β60, IA-2β64, and IA-2β71. In this study, we analyzed the tissue-, cell- and organelle-specific distributions o...

journal_title：Life sciences

authors： Nakajima K,Wu G,Sakudo A,Onodera T,Takeyama N

更新日期：2011-04-25 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) has a neurotrophic effect both in vitro and in vivo, and is considered to play an important role in the maintenance of neuronal functions in the normal brain. Neural damage in brain contusion progresses after the primary injury of trauma because of cerebral hemodynamic and metabol...

journal_title：Life sciences

authors： Iwamoto Y,Yamaki T,Murakami N,Sugawa N,Yoshino E,Ueda S,Nosaka K,Nishino H,Iwashima A

更新日期：1994-01-01 00:00:00

abstract：:Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present...

journal_title：Life sciences

authors： Gomes FG,Nedel F,Alves AM,Nör JE,Tarquinio SB

更新日期：2013-02-07 00:00:00

abstract：:The effects of chronic treatment with piracetam (100 mg/Kg) plus choline (100 mg/Kg) on rabbits' hippocampal electrical activity and behavior have been studied. Animals were exposed to a neutral environment, in the absence of any external stimulus, and then to an object and a stuffed sparrow-hawk. Results show a drug ...

journal_title：Life sciences

authors： Fontani G,Grazzi F,Meucci M

更新日期：1984-09-10 00:00:00

abstract：:To determine the mechanism of anoxic vasoconstriction, precontracted rat aortic rings were exposed to 95% N2, which caused additional contraction. Reoxygenation (95% O2) resulted in initial relaxation followed by contraction. Indomethacin did not affect anoxic contraction or reoxygenation-mediated events, but NG-monom...

journal_title：Life sciences

authors： Mehta JL,Lawson DL,Yang BC,Haught WH,Hintze T

更新日期：1991-01-01 00:00:00

abstract：:XY99-5038 is a preparation from a specific formula provided by Dr. Yan Xin, a renowned Traditional Chinese Medicine specialist. This formulation has proven to be effective without side effects but has not been studied under rigorous laboratory conditions. In order to investigate the role of XY99-5038 in protecting neu...

journal_title：Life sciences

authors： Xin Y,Fong YT,Wolf G,Wolf D,Cao W

更新日期：2001-06-08 00:00:00

abstract：:The aggregation of melanin-granules within fish pigment cells (melanophores) can be elicited either by electrical stimulation of intrinsic nerves or by the addition of adrenergic agonists. The pigment aggregation seems to be mediated by alpha-2-adrenoceptors. In this investigation we have used various agonists and ant...

journal_title：Life sciences

authors： Karlsson JO,Grundström N,Wikberg JE,Friedman R,Andersson RG

更新日期：1985-09-16 00:00:00

abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...

journal_title：Life sciences

authors： Bharadwaj S,Lee KE,Dwivedi VD,Kang SG

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide. For advanced-stage patients, chemotherapeutic drugs are the best treatment option; however, their adverse effects and high cost are still major obstacles for effecti...

journal_title：Life sciences

authors： Mahmoud YI,Shehata AMM,Fares NH,Mahmoud AA

更新日期：2021-01-15 00:00:00

abstract：:Recent studies suggest that protein kinase C and, thus, possibly the rate of inositol phospholipid hydrolysis may regulate the function and distribution of the asialoglycoprotein (or galactosyl) receptor on isolated rat hepatocytes (Takahashi et al., Biochem. Biophys. Res. Commun., 1985, 126, 1054; Fallon and Schwartz...

journal_title：Life sciences

authors： Medh JD,Haynes PA,Weigel PH,LaBelle EF

更新日期：1989-01-01 00:00:00

abstract：:We assessed the anxiolytic effect of Kami-Shoyo-San (Jia-wei-xiao-yao-san; TJ-24), one of a traditional Chinese herbal medicine used for the treatment of menopausal anxiety, by the social interaction (SI) test in male mice. Acute administration of TJ-24 (25-100 mg/kg, p.o.), as well as the gamma-amino-butyric acidA/be...

journal_title：Life sciences

authors： Mizowaki M,Toriizuka K,Hanawa T

更新日期：2001-09-21 00:00:00

abstract：:Nitric oxide (NO) surprisingly caused the opposite effect on histamine and serotonin edema. The local injection of acidified nitrite (0.3-30 micrograms/paw which correspond 10 micrograms-1 mg/kg) increased histamine edema of mice up to 45 +/- 4% and suppressed serotonin edema to 90 +/- 3%. Other NO-generators (nitropr...

journal_title：Life sciences

authors： Oyanagui Y,Sato S

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been found to contribute to the failure of ovarian carcinoma treatment. Oridonin is a natural en-kaurane tetracyclic diterpenoid compound discovered in Rabdosia rubescene (Henmsl.) Hara. Herein, we tested whether oridonin could exert chemo-sensitization activity on cisplatin-resistan...

journal_title：Life sciences

authors： Zhao Y,Xia H

更新日期：2019-09-15 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and ...

journal_title：Life sciences

authors： Myers WD,Mackenzie L,Ng KT,Singer G,Smythe GA,Duncan MW

更新日期：1985-01-28 00:00:00

abstract：:Based on the finding of decreased mitochondrial complex I activity in the substantia nigra of patients with Parkinson's disease, we propose that the consequent reduction of ATP synthesis and increased generation of reactive oxygen species may be a possible cause of nigrostriatal cell death. Since sulfhydryl groups are...

journal_title：Life sciences

authors： Martínez M,Martínez N,Hernández AI,Ferrándiz ML

更新日期：1999-01-01 00:00:00

abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...

journal_title：Life sciences

authors： Filloux F,Richards TJ,Huff GF,Wamsley JK

更新日期：1991-01-01 00:00:00

abstract：:Quercetin, a plant flavonoid, blocks signal transduction pathways by inhibiting 1-phosphatidylinositol 4-kinase (EC 2.7.1.67, PI kinase) and 1-phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68, PIP kinase), resulting in a reduction of inositol 1,4,5-trisphosphate (IP3) concentration which decreases the release of...

journal_title：Life sciences

authors： Yeh YA,Herenyiova M,Weber G

更新日期：1995-01-01 00:00:00

abstract：:A natural product betulinic acid (BA) has gained a huge significance in the recent years for its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer protecting agent on a variety of tumor cells, the normal cells and tissues are rarely affected by BA. Betulinic acid and analogues (BAs) generally ...

journal_title：Life sciences

authors： Kumar P,Bhadauria AS,Singh AK,Saha S

更新日期：2018-09-15 00:00:00

abstract：AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...

journal_title：Life sciences

authors： Mashimo M,Iwasaki Y,Inoue S,Saito S,Kawashima K,Fujii T

更新日期：2017-03-01 00:00:00

abstract：:Superoxide dismutase (SOD), neuron specific enolase (NSE) and lactic dehydrogenase (LDH) were measured in the serum and cerebrospinal fluid (CSF) of ischemic cerebrovascular patients, other neurological patients and in age-matched healthy controls (serum only). The levels of SOD in the CSF or serum of the ischemic pat...

journal_title：Life sciences

authors： Gruener N,Gross B,Gozlan O,Barak M

更新日期：1994-01-01 00:00:00

abstract：:Psychostimulants including amphetamine and cocaine induce locomotion and stereotypy and suppress eating. Although the capacity of cocaine to alter locomotion is usually viewed as related to dopamine neurotransmission, recent studies suggest that norepinephrine, acting through alpha1-adrenergic receptors (alpha1-ARs) c...

journal_title：Life sciences

authors： Clifford PS,Davis KW,Elliott AE,Wellman PJ

更新日期：2007-09-08 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

journal_title：Life sciences

authors： Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

更新日期：2020-09-15 00:00:00