Abstract：
:Basic fibroblast growth factor (bFGF) has a neurotrophic effect both in vitro and in vivo, and is considered to play an important role in the maintenance of neuronal functions in the normal brain. Neural damage in brain contusion progresses after the primary injury of trauma because of cerebral hemodynamic and metabolic impairment including intracranial hemorrhage and/or brain swelling. Northern blot analysis of bFGF mRNA was performed in rats after cerebral contusion produced by our modified fluid percussion device. Expression of bFGF mRNA increased significantly on the second day after trauma. A possible role of bFGF is functioning to protect the critical neurons from secondary neural damage in cerebral contusion.
journal_name
Life Scijournal_title
Life sciencesauthors
Iwamoto Y,Yamaki T,Murakami N,Sugawa N,Yoshino E,Ueda S,Nosaka K,Nishino H,Iwashima Adoi
10.1016/0024-3205(94)00332-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1651-6issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(94)00332-7journal_volume
55pub_type
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