Abstract:
:Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and salsolinol concentrations in the medial basal hypothalamus but not striatum. The data suggest that the occurrence of salsolinol in rat brain tissue is a consequence of an in vivo Pictet-Spengler cyclization.
journal_name
Life Scijournal_title
Life sciencesauthors
Myers WD,Mackenzie L,Ng KT,Singer G,Smythe GA,Duncan MWdoi
10.1016/0024-3205(85)90115-8subject
Has Abstractpub_date
1985-01-28 00:00:00pages
309-14issue
4eissn
0024-3205issn
1879-0631pii
0024-3205(85)90115-8journal_volume
36pub_type
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