Abstract：
:Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly higher levels of cortisol during a cold challenge than either ANA positive patients or normal controls, and exhibited significantly lower levels of plasma norepinephrine compared with normal controls. ANA positive patients did not differ significantly from normals in their neuroendocrine response to cold. It is suggested that the high plasma cortisol found in Raynaud's syndrome in the absence of ANA may be responsible for the vasospasticity in this group of patients.
journal_name
Life Scijournal_title
Life sciencesauthors
Surwit RS,Allen LM 3rd,Gilgor RS,Schanberg S,Kuhn C,Duvic Mdoi
10.1016/0024-3205(83)90930-xsubject
Has Abstractpub_date
1983-02-28 00:00:00pages
995-1000issue
9eissn
0024-3205issn
1879-0631pii
0024-3205(83)90930-Xjournal_volume
32pub_type
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