Abstract：
:Adrenocortical activity varies on a circannual basis with increased secretion in the winter and decreased secretion in the summer. One consequence of this variation is a circannual pattern in immune function. Adrenal corticosteroids, especially glucocorticoids, depress cellular immune function and seem to be more effective against T-suppressor cells. Thus, when adrenocortical activity is elevated, T-cell activity is depressed and B-cell activity is elevated. To the extent that T-cell "surveillance" is depressed in winter, there should be increased lymphoproliferative cancer risk during winter and in regions characterized by cold climates. This article presents data which suggest: (1) a winter, adrenal-corticoid induced, depression of T-cell function which is accompanied by elevated B-cell function; (2) elevated serum immunoglobulin levels in the winter; and (3) an inverse relationship between ambient temperature and serum immunoglobulin levels. The circannual pattern in immune function could help explain increased lymphoproliferative cancer risk, as a side effect of immunosuppression therapy during organ transplants, and as a function of latitude.
journal_name
Life Scijournal_title
Life sciencesauthors
MacMurray JP,Barker JP,Armstrong JD,Bozzetti LP,Kuhn INdoi
10.1016/0024-3205(83)90767-1subject
Has Abstractpub_date
1983-05-16 00:00:00pages
2363-70issue
20eissn
0024-3205issn
1879-0631pii
0024-3205(83)90767-1journal_volume
32pub_type
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