Metoprolol reduces 'compensatory' coronary blood flow following occlusion of an adjacent branch without altering post-occlusion hyperaemia.

abstract：:Obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM) are associated with heightened cardiovascular risk. Given the vasoconstrictor and proatherogenic properties of endothelin (ET)-1, increased ET-1 activity has been postulated to participate in the derangement of adiposity-related vascular homeostasis. T...

journal_title：Life sciences

authors： Campia U,Tesauro M,Di Daniele N,Cardillo C

更新日期：2014-11-24 00:00:00

abstract：:Inositol hexaphosphate (InsP6 or IP6) is ubiquitous. At 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) as well as inositol (Ins) are contained in most mammalian cells, wherein they are important in regulating vital cellular functions such as signal transduction, cell proliferation a...

journal_title：Life sciences

authors： Shamsuddin AM,Vucenik I,Cole KE

更新日期：1997-01-01 00:00:00

abstract：:Increasing understanding in tumor pathology reveals that tumor microenvironment (TME), which supports tumor progression and poses barriers for available therapies, takes a great responsibility in inefficient treatment and poor prognosis. In recent years, the versatile nanotechnology employed in TME regulation has made...

journal_title：Life sciences

authors： Li M,Zhang F,Su Y,Zhou J,Wang W

更新日期：2018-05-15 00:00:00

abstract：:Novel magnetic resonance imaging sequences have and still continue to play an increasing role in neuroimaging and neuroscience. Among these techniques, diffusion-weighted imaging (DWI) has revolutionized the diagnosis and management of diseases such as stroke, neoplastic disease and inflammation. However, the effects ...

journal_title：Life sciences

authors： Rau PR,Sellner J,Heiland S,Plaschke K,Schellinger PD,Meyding-Lamadé UK,Lamadé WR

更新日期：2006-02-09 00:00:00

abstract：:Diazepam (0.4-4 mg/kg i.p.) reduced the spontaneous tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han-Wistar rats in a dose-dependent manner. The muscle relaxant effect of diazepam was antagonized by the benzodiazepine antagonists Ro 15-1788 (5 mg/kg i.p.), ...

journal_title：Life sciences

authors： Schwarz M,Turski L,Sontag KH

更新日期：1984-10-01 00:00:00

abstract：:The loss of osteoblast function in aging bone is one of the major causes of osteopenia, or loss of bone mass. In this study, this loss of function was investigated by examining the proliferative response of rat long bone periosteal osteoblasts to TGF(beta1) and 1,25-dihydroxy vitamin D(3) (1,25-D(3)) as a function of ...

journal_title：Life sciences

authors： Shiels MJ,Mastro AM,Gay CV

更新日期：2002-05-10 00:00:00

abstract：:Immunoreactive- (IR-) somatostatin (SRIF), neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) contents were investigated in the brain of tremor rats with absence-like seizure and spontaneously epileptic rats (SER), which is a genetically defined double-mutant (zi/zi, tm/tm) obtained by mating zitter homozyg...

journal_title：Life sciences

authors： Sadamatsu M,Kanai H,Masui A,Serikawa T,Yamada J,Sasa M,Kato N

更新日期：1995-01-01 00:00:00

abstract：:The effect of the repeated or continuous administration of an analog of GH releasing factor (GH-RF), D-Tyr-1, D-Ala-2, Nle-27, GH-RF(1-29)-NH2 (DBO-29), on the subsequent response to this peptide was investigated in pentobarbital-anesthetized male rats. A sc administration of this analog induced a greater and more pro...

journal_title：Life sciences

authors： Karashima T,Olsen D,Schally AV

更新日期：1987-06-22 00:00:00

abstract：:The optical isomers of apomorphine (APO) and N-propylnorapomorphine (NPA) were interacted with three biochemical indices of dopamine (DA) receptors in extrapyramidal and limbic preparations of rat brain tissue. There were consistent isomeric preferences for the R(-) configuration of both DA analogs in stimulating aden...

journal_title：Life sciences

authors： Kula NS,Baldessarini RJ,Bromley S,Neumeyer JL

更新日期：1985-09-16 00:00:00

abstract：AIMS:To explore the carcinostatic effects of platinum nanocolloid (Pt-nc) combined with gamma rays on human esophageal squamous cell carcinoma (ESCC). MAIN METHODS:ESCC-derived KYSE-70 cells were treated with various concentrations of Pt-nc and/or gamma irradiation, and subsequently cultured in phenol red free DMEM wi...

journal_title：Life sciences

authors： Li Q,Tanaka Y,Saitoh Y,Tanaka H,Miwa N

更新日期：2015-04-15 00:00:00

abstract：:The renal hemodynamic and tubular effects of ANF were investigated using the Sperber technique in chickens. This technique takes advantage of the unique portal circulation of the avian kidney and permits direct access to the renal peritubular space independent of renal arterial blood flow and glomerular filtration. In...

journal_title：Life sciences

authors： Springate JE,Fildes RD,Hong SK,Feld LG,Acara M

更新日期：1987-03-09 00:00:00

abstract：:The analgesic buprenorphine hydrochloride (Bph) induced apoptosis-like cell death in the caspase-3-deficient human breast cancer cell line, MCF-7. This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6. Bph caused the release of ...

journal_title：Life sciences

authors： Kugawa F,Matsumoto K,Aoki M

更新日期：2004-06-04 00:00:00

abstract：:The effects of naloxone or thyrotropin releasing hormone (TRH) upon neurologic outcome were evaluated in gerbil models of cerebral ischemia. Following temporary bilateral carotid occlusion, hypotension was transiently reversed by these endorphin antagonists. However, neither drug altered time to awaken, time to death,...

journal_title：Life sciences

authors： Holaday JW,D'Amato RJ

更新日期：1982-07-26 00:00:00

abstract：:The aim of the present work was to study the effects of various durations of fasting (12, 24 and 72 hours) on brown adipose tissue (BAT) thermogenic parameters--cytrochrome-c-oxidase (COX) activity, GDP-binding activity and uncoupling protein (UCP1) content--and also on morphological features of different mitochondria...

journal_title：Life sciences

authors： Gianotti M,Clapés J,Lladó I,Palou A

更新日期：1998-01-01 00:00:00

abstract：:Regulation of glucose-induced oscillations in intracellular Ca2+ concentration ([Ca2+]i) was investigated by using a novel technique, electroporation from an electrolyte-filled capillary, to deliver energy metabolites to the intracellular compartment of mouse islets. Intracellular application of ATP resulted in a nife...

journal_title：Life sciences

authors： Dahlgren GM,Nolkrantz K,Kennedy RT

更新日期：2005-10-21 00:00:00

abstract：:We find a significantly lower level of specific [3H]nicotine binding in the fetal rat forebrain of 20 day gestational age as compared to adult rat tissue, and a progressive increase in the [3H]nicotine binding in the early neonatal forebrain, reaching adult level at 14-28 days of age. The maximal binding sites (Bmax) ...

journal_title：Life sciences

authors： Yamada S,Kagawa Y,Isogai M,Takayanagi N,Hayashi E

更新日期：1986-02-17 00:00:00

abstract：:The use of xenon as an almost ideal anesthetic with very little side effects is gaining clinical acceptance, yet its effects on the cellular level are still unclear. It affects intracellular Ca2+-homeostasis but up to now no cellular event or Ca2+-signaling system has been described to be specifically sensitive to xen...

journal_title：Life sciences

authors： Petzelt C,Taschenberger G,Schmehl W,Hafner M,Kox WJ

更新日期：1999-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are integral membrane proteins that, in response to activation by extracellular stimuli, regulate intracellular second messenger levels via their coupling to heterotrimeric G proteins. GPCR activation also initiates a series of molecular events that leads to G protein-coupled recept...

journal_title：Life sciences

authors： Seachrist JL,Ferguson SS

更新日期：2003-12-05 00:00:00

abstract：:Single unit recordings were obtained from putative dopaminergic neurons in the substantia nigra of awake, freely moving rats. The cells exhibited waveforms, range of firing rates and types of firing patterns identical to those of identified DA neurons of anesthetized or paralyzed rats. Two firing patterns were observe...

journal_title：Life sciences

authors： Freeman AS,Meltzer LT,Bunney BS

更新日期：1985-05-20 00:00:00

abstract：AIMS:Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chro...

journal_title：Life sciences

authors： Zhou MW,Jiang RH,Kim KD,Lee JH,Kim CD,Yin WT,Lee JH

更新日期：2016-06-15 00:00:00

abstract：:We had previously hypothesized that linoleic acid (LA) was essential for development of alcoholic induced liver injury in our rat model. Male Wistar rats were fed a nutritionally adequate diet (25% calories as fat) with ethanol (8-17 g/kg/day). The source of fat was tallow (0.7% LA), lard (2.5% LA) or tallow supplemen...

journal_title：Life sciences

authors： Nanji AA,French SW

更新日期：1989-01-01 00:00:00

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：:In primary cultured bovine adrenal chromaffin cells (BACC), pituitary adenylate cyclase activating polypeptide 1-38 (PACAP) produced a dose related increase in tyrosine hydroxylase (TH) Vmax when measured 48 hours after the beginning of the treatment; a significant increase was observed with 0.5 nM and the maximal ind...

journal_title：Life sciences

authors： Rius RA,Guidotti A,Costa E

更新日期：1994-01-01 00:00:00

abstract：:Food allergies have become increasingly prevalent during the past few decades. Diarrhea is one of the most frequent intestinal symptoms caused by food allergens and is characterized by imbalanced ion exchange and water transfer; however, the underlying mechanism of allergic diarrhea remains unclear. Water transfer acr...

journal_title：Life sciences

authors： Yamamoto T,Kuramoto H,Kadowaki M

更新日期：2007-06-20 00:00:00

abstract：:Despite considerable progressions, cardiovascular disease (CVD) is still one of the major causes of mortality around the world, indicates an important and unmet clinical need. Recently, extensive studies have been performed on the role of inflammatory factors as either a major or surrogate factor in the pathophysiolog...

journal_title：Life sciences

authors： Soroureddin Z,Nouri-Vaskeh M,Maleki M,Baghbanzadeh A,Hajiasgharzadeh K,Taban Sadeghi M,Baradaran B

更新日期：2020-07-15 00:00:00

abstract：:We have developed an assay for serotonin (5-HT) stimulation of adenylate cyclase activity in membranes from adult guinea pig hippocampus. The response to 5-HT is concentration-dependent, with an EC50 of 0.01 microM, a shallow slope, and mean maximal stimulation of 90% over basal activity. The response to 5-HT is GTP-d...

journal_title：Life sciences

authors： Shenker A,Maayani S,Weinstein H,Green JP

更新日期：1983-05-16 00:00:00

abstract：:We conducted a study to determine whether angiotensin converting enzyme inhibitors (ACEIs) inhibit endothelin secretion from cultured human endothelial cells. Confluent umbilical vein endothelial cells were incubated in multi-well plates with culture medium containing either captopril (10(-6), 10(-5), 10(-4) M) or ena...

journal_title：Life sciences

authors： Yoshida H,Nakamura M

更新日期：1992-01-01 00:00:00

abstract：:Polyamines (spermidine, spermine and putrescine) inhibited the adenylate cyclase activity in a concentration dependent manner in human erythrocyte plasma membranes. Spermidine (Spd) exhibited more inhibitory effect than spermine (Spm) and putrescine (Put). On the contrary, the addition of amino acids (arginine, glutam...

journal_title：Life sciences

authors： Khan NA,Quemener V,Moulinoux P

更新日期：1990-01-01 00:00:00

abstract：:The antiarrhythmic and cardioprotective drug stobadine, possessing antioxidant and neuroprotective properties, was studied as to its in vitro effect on aggregation of human blood platelets. Pretreatment of platelets with stobadine for 30 s inhibited stimulated platelet aggregation in a dose-dependent way. Depending on...

journal_title：Life sciences

authors： Jancinová V,Nosál R,Danihelová E

更新日期：1999-01-01 00:00:00

abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...

journal_title：Life sciences

authors： Kumari P,Roy K,Wadhwa M,Chauhan G,Alam S,Kishore K,Ray K,Panjwani U

更新日期：2020-08-01 00:00:00