Abstract：
:Despite considerable progressions, cardiovascular disease (CVD) is still one of the major causes of mortality around the world, indicates an important and unmet clinical need. Recently, extensive studies have been performed on the role of inflammatory factors as either a major or surrogate factor in the pathophysiology of CVD. Epidemiological observations suggest the theory of the role of inflammatory mediators in the development of cardiovascular events. This may support the idea that targeted anti-inflammatory therapies, on the background of traditional validated medical therapies, can play a significant role in prevention and even reduction of cardiovascular disorders. Many randomized controlled trials have shown that drugs commonly useful for primary and secondary prevention of CVD have an anti-inflammatory mechanism. Further, many anti-inflammatory drugs are being examined because of their potential to reduce the risk of cardiovascular problems. In this study, we review the process of inflammation in the development of cardiovascular events, both in vivo and clinical evidence in immunotherapy for CVD.
journal_name
Life Scijournal_title
Life sciencesauthors
Soroureddin Z,Nouri-Vaskeh M,Maleki M,Baghbanzadeh A,Hajiasgharzadeh K,Taban Sadeghi M,Baradaran Bdoi
10.1016/j.lfs.2020.117720subject
Has Abstractpub_date
2020-07-15 00:00:00pages
117720eissn
0024-3205issn
1879-0631pii
S0024-3205(20)30468-9journal_volume
253pub_type
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