Abstract：
:Rats treated chronically with the anticancer agent adriamycin (1.5 mg/kg/week X 14 weeks) exhibited cardiac and renal lesions typical of anthracycline toxicity, and had serum hyperlipidemia characterized by 4 to 10 fold elevations in all lipoprotein classes. Heparin-releasable lipoprotein lipase activity measured in perfused heart preparations was decreased 69% in adriamycin-treated rats compared to saline-treated controls. Residual (non-heparin-releasable) activity was not significantly different after adriamycin treatment. The decrease in functional cardiac lipoprotein lipase may account, at least in part, for the serum hyperlipidemia observed in adriamycin-treated rats, and might play a role in the development of heart muscle disease.
journal_name
Life Scijournal_title
Life sciencesauthors
Thayer WSdoi
10.1016/0024-3205(85)90167-5subject
Has Abstractpub_date
1985-02-18 00:00:00pages
635-41issue
7eissn
0024-3205issn
1879-0631pii
0024-3205(85)90167-5journal_volume
36pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Acute renal injury (AKI) is a risk factor for the development of hypertension, which involves oxidative stress, changes in Na+ handling, and the intrarenal renin-angiotensin-aldosterone system (RAAS) as underlying mechanisms. We investigated in rats whether renal ischemia-reperfusion (IR) leads to changes in the proxi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118879
更新日期：2021-02-01 00:00:00
abstract：:Endothelins (ET) are 21-amino acid peptides that bind to membrane receptors to initiate a wide range of pathophysiological effects. PD-156707, L-749329, Ro-470203, and A-127722 are potent non-peptide ET receptor antagonists developed recently. When tested in human and rat plasma, both ET-1 and -3 and the four aforemen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00168-3
更新日期：1996-01-01 00:00:00
abstract：:Following severe thermal injury, patients are resistant to non-depolarizing muscle relaxants. Although this resistance has been well documented clinically, little is known about its etiology. We have tested the hypothesis that circulating factors contribute to the decreased potency of neuromuscular blockers following ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90234-2
更新日期：1988-01-01 00:00:00
abstract：:Carbachol (CCH), serotonin (5HT), divalent ionophore A23187, cAMP, and certain neuropeptides, i.e. substance P (SP), inhibit the initial rate of uptake (influx) of 22Na into isolated chicken villus enterocytes. All these agents also increase cytosolic Ca. However, the increases stimulated by CCH, 5HT, and cAMP are not...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90506-m
更新日期：1990-01-01 00:00:00
abstract：:Recent reports indicate that some imidazole-5-acetic acid derivatives are competitive antagonists of angiotensin II receptors. However, to our knowledge, there is no published information regarding: 1) what constant infusion rate of these non-peptide angiotensin receptor blockers is necessary to effectively antagonize...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90096-a
更新日期：1990-01-01 00:00:00
abstract：:Aberrant methylation of promoter CpG islands (CGIs) can inactivate the expression of many tumor suppressor genes and play an important role in the carcinogenesis of gastric cancer. The tumor suppressor gene RB1, which encodes a cell cycle regulator, is hypermethylated and downregulated in multiple kinds of cancer. Act...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118580
更新日期：2020-12-15 00:00:00
abstract：AIMS:Oncogenic RET/PTC1 chromosomal rearrangements are hallmarks of thyroid papillary carcinoma. The resulting protein, mainly through tyrosine 451, is responsible for the activation of pathways controlling cell survival, including the PI3K/Akt/mTOR cascade. Vanadium compounds were shown to have anti-neoplastic potenti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.07.004
更新日期：2011-09-12 00:00:00
abstract：AIM:Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethan...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.08.037
更新日期：2017-11-01 00:00:00
abstract：AIM:The purpose of this study was to investigate whether the flavonoid quercetin can prevent alterations in the behavioral tests and of cholinergic neurotransmission in rats submitted to the ethidium bromide (EB) experimental demyelination model during events of demyelination and remyelination. MAIN METHODS:Wistar rat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.03.033
更新日期：2014-05-17 00:00:00
abstract：:Although intraepithelial T lymphocytes of the large intestine (LI) are known to differ from those of the small intestine (SI) in phenotype and function, differences in LI and SI lamina propria (LP) lymphocyte populations have not been clearly established. In this work we found striking phenotypic differences between S...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.08.042
更新日期：2005-04-29 00:00:00
abstract：:The antioxidative and superoxide- and hydroxyl radical-scavenging activities and pro-oxidant effect of twelve selected medicinal herbs were studied. The aqueous extracts of Coptis chinensis, Paeonia suffruticosa, Prunella vulgaris and Senecio scandens exhibited the highest potency in inhibiting rat erythrocyte hemolys...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00643-8
更新日期：2000-01-14 00:00:00
abstract：AIMS:Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration after partial hepatectomy. While the mechanism of splenectomy promotes liver regeneration by the improvement of the formation of tight junction and the establishment of hepatocyte polarity is still unknown. MA...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.11.032
更新日期：2018-01-01 00:00:00
abstract：:Uncoupling proteins are a family of mitochondrial proteins involved in energy metabolism. We previously showed that uncoupling protein 4 (UCP4) is differentially expressed in omental adipose tissue in diet-induced obese and normal rats. However, the effect of UCP4 on adipocytes is unclear. In this work, we established...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.04.012
更新日期：2006-09-05 00:00:00
abstract：:Bacitracin (BAC) U.S.P., obtained in the form of sterile powder, elicits dose-dependent and non-tachyphylactic contractions of the rabbit isolated aorta and of other rabbit vessels. The use of several pharmacologic antagonists suggests that BAC is a 5-hydroxytryptamine mimetic in aortic strips, since the antibiotic is...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90355-u
更新日期：1990-01-01 00:00:00
abstract：:Psoriasis is an inflammatory skin disease with preference for the skin and joints that occurs due to hyper-proliferation and abnormal apoptosis of keratinocytes. DUSP1 expression in dermal mesenchymal stem cells (MSCs) is obviously lower in psoriasis patients than that in healthy individuals. The present study aimed t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.018
更新日期：2019-04-15 00:00:00
abstract：:Neuropathic pain syndromes respond poorly to opioid treatment. In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino aci...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.08.020
更新日期：2006-03-13 00:00:00
abstract：AIMS:We investigated whether cAMP-mediated protein kinase A(PKA) and Epac1/Rap1 pathways differentially affect brain tumor cell death using 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone(rolipram), specific phosphodiesterase type IV(PDE IV) inhibitor. MAIN METHODS:A172 and U87MG human glioblastoma cells were used....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.12.010
更新日期：2012-02-27 00:00:00
abstract：AIMS:Splenectomy is sometimes required in bone fracture patients. The present study aims to investigate the effect of splenectomy on fracture healing in rats. MAIN METHODS:Rats underwent osteotomy were subjected to splenectomy. The effects of splenectomy were evaluated at day 0, 3, 15 and 30 post-fracture. Double immu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.12.005
更新日期：2017-03-15 00:00:00
abstract：:Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90930-x
更新日期：1983-02-28 00:00:00
abstract：AIMS:Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship between serotonergic neurons and amino acid neurons in the lumbosacral c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.08.013
更新日期：2009-10-07 00:00:00
abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01507-2
更新日期：2002-04-05 00:00:00
abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.05.021
更新日期：2018-07-15 00:00:00
abstract：:Clinical trials with muscarinic agonists or acetylcholine esterase inhibitors for the treatment of Alzheimer's dementia have shown disappointing or equivocal results. An alternative treatment of this disease is the development of drugs which enhance the release of acetylcholine. It is believed, that of the five muscar...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(93)90307-o
更新日期：1993-01-01 00:00:00
abstract：:A simple procedure has been developed for the large scale purification of fetal bovine serum acetylcholinesterase (AChE) (EC 3.1.1.7). The procedure involves two steps: batch adsorption of the AChE from 250 L of serum onto a procainamide affinity Sepharose 4B gel; and analytical procainamide affinity chromatography of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90530-8
更新日期：1986-07-21 00:00:00
abstract：:The presence of gonadotropin-releasing hormone (GnRH) binding sites in biopsy samples of human epithelial ovarian cancer and ovarian tumor cell lines as well as the demonstration of the inhibitory effects of GnRH analogues on the growth of these cells raised the possibility that GnRH is produced locally by ovarian can...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00173-8
更新日期：1998-01-01 00:00:00
abstract：AIMS:TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor development. However, the specific mechanism causes and promotes of colorectal cancer keep largely unknown. Therefore, we sought to investigate the roles and the molecular mechanisms of TRAF6 in regulation colorectal cancer. MATER...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116831
更新日期：2019-10-15 00:00:00
abstract：:In the present investigation, Fischer-344 rats were trained to discriminate 10.0 mg/kg of ibogaine from water using a pretreatment time of 60 minutes. Analysis of dose response data generated an ED50 of 4.6 mg/kg. The time course of the ibogaine (10.0 mg/kg) cue was also determined. The stimulus reached a maximum leve...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00703-5
更新日期：1997-01-01 00:00:00
abstract：:The hypothermia induced by apomorphine, a mixed dopamine (DA) agonist in male Swiss-Webster mice, was not blocked by the selective D-1 antagonist SCH 23390 but was completely blocked by the selective D-2 antagonists haloperidol, sulpiride and YM-09151-2. The selective D-1 agonist SKF 38393 did not elicit hypothermic r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90515-2
更新日期：1988-01-01 00:00:00
abstract：:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90595-7
更新日期：1983-01-01 00:00:00
abstract：:Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium-dependent calcium-stimulated adenosine triphosphatase ( ( Ca + Mg)-ATPase, EC 3.6.1.3.) of the red cell plasma membrane was not significantly changed. Maximal ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90622-7
更新日期：1983-08-29 00:00:00
