Abstract：
AIM:Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethanol and heating and to understand the underlying mechanisms leading to their synergistic effect. MATERIALS AND METHODS:Isometric tension of rabbit carotid artery ring segments suspended in organ baths filled with Krebs solution was recorded. Different concentrations of ethanol were examined at 37°C and during temperature elevation to39-43°C. Capsaicin and capsazepine were used to examine the mechanism of action of ethanol. KEY FINDINGS:Ethanol induced contraction at 37°C when the concentration reached 100mM. Contraction was observed at any concentration at higher temperatures. Ethanol potentiated heat-induced contraction. Capsaicin, the vanilloid receptor subtype1 (TRPV1) agonist, potentiated the vasoconstriction due to heating. While capsazepine, TRPV1 antagonist, abolished the effect of ethanol and its potentiation of heating-induced contraction, but it did not abolish the heating effect. SIGNIFICANCE:Ethanol's mechanism of action and its effect on heating induced-vasoconstriction of the carotid artery is being mediated by TRPV1. The combination of ethanol and hyperthermia can lead to a synergistic effect on carotid vasoconstriction. This effect may induce brain damage and heat stroke. Development of new drugs act as TRPV1 antagonist can be used to prevent these fatal effects.
journal_name
Life Scijournal_title
Life sciencesauthors
Mustafa S,Ismael HNdoi
10.1016/j.lfs.2017.08.037subject
Has Abstractpub_date
2017-11-01 00:00:00pages
83-86eissn
0024-3205issn
1879-0631pii
S0024-3205(17)30430-7journal_volume
188pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00328-2
更新日期：1998-01-01 00:00:00
abstract：AIMS:Morus, a member of the family Moraceae and commonly known as the mulberry, comprises a pharmaceutically important plant group whose major constituents are the moracins. Moracin derivatives have received great attention because they exhibit a diverse range of biological functionalities. However, no studies have con...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.060
更新日期：2018-10-01 00:00:00
abstract：:Effects of ethanol in vitro on membrane vesicles (microsacs prepared from mouse cerebral cortex) were evaluated by monitoring 36Cl- influx. Different assay parameters were tested to determine increased or decreased action of ethanol on GABA-activated chloride channels. The ability of 30 mM ethanol to augment 36Cl- flu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90009-g
更新日期：1990-01-01 00:00:00
abstract：:Previous studies have shown that cytochrome P450-Arachidonic Acid (P450-AA) metabolites modify the vascular tone of several vessels and that vasopressin (AVP) stimulates P450-AA metabolism. Thus, in the present study, we decided to investigate if the vasoconstrictor effect of AVP is related to activation of P450-AA me...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00108-i
更新日期：1995-01-01 00:00:00
abstract：:Immunization with plasmid DNA encoding antigenic proteins elicits both antibody and cell-mediated immune responses. This method of producing the protein antigens of interest directly in host cells can provide appropriate tertiary structure for the induction of conformationally specific antibodies, and also facilitates...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(96)00502-4
更新日期：1997-01-01 00:00:00
abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00770-4
更新日期：1997-01-01 00:00:00
abstract：:The kinetics of lymphocyte function associated antigen 1 (LFA-1) expression on spleen cells (SPC) and liver non-parenchymal cells (NPC), and intercellular adhesion molecule 1 (ICAM-1) expression on hepatocytes (HC) was examined in acute liver injury mice induced by a DTH reaction to picryl chloride (PCl). The peak exp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00062-9
更新日期：1998-01-01 00:00:00
abstract：:Within 4 minutes a single, intravenous injection of nicotine (0.3 mg/Kg) induced increases in somatostatin-like immunoreactivity concentrations in the rat hypothalamus but not in the striatum. These changes were associated with a significant increase in the specific binding of somatostatin to putative receptor sites i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90116-7
更新日期：1992-01-01 00:00:00
abstract：:The binding of different gangliosides to rat T-helper lymphocytes was characterized under conditions that decrease CD4 expression on different mammalian T-helper lymphocytes. Saturation binding by monosialylated [3H]-GM1 to rat T-lymphocytes was time- and temperature-dependent, had a dissociation constant (KD) of 2.2 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90123-9
更新日期：1989-01-01 00:00:00
abstract：:Biphasic cutaneous reaction with peak response at 1 (early phase) and 24 to 48 hour (late phase) was elicited by epicutaneous challenge with antigen in actively and passively sensitized mice. Mice were actively immunized with dinitrophenylated (DNP) ascaris antigen and challenged with dinitrofluorobenzene (DNFB). Pass...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00859-0
更新日期：1994-01-01 00:00:00
abstract：:In the field of estrogen therapy breast cancer risk is one of the most controversially discussed topic. Actually, the as yet largest placebo-controlled study, the Women's Health Initiative, rather showed a risk reduction, in contrast to observational studies. In the present study we have investigated the effect of est...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.07.042
更新日期：2006-02-23 00:00:00
abstract：:We studied the effect of thapsigargin on intracellular calcium levels ([Ca2+]i) measured by fura-2 fluorimetry in Madin Darby canine kidney (MDCK) cells. Thapsigargin elevated [Ca2+]i dose dependently with an EC50 of approximately 0.15 microM. The Ca2+ signal consisted of a slow rise, a gradual decay and a plateau. De...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00561-x
更新日期：1999-01-01 00:00:00
abstract：:Previous studies showed that acute treatment with aminophylline (AMPY) significantly elevated maximum thermogenesis and improved cold tolerance in rats and man in severe cold. However, the exact mechanism by which AMPY enhances thermogenesis was unknown. Rats receiving enprofylline (ENPRO) (1.5 and 15 mg/kg, i.p.), a ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90491-8
更新日期：1989-01-01 00:00:00
abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.064
更新日期：2016-04-15 00:00:00
abstract：:Static sense organs composed of a hollow statocyst surrounded by sensory hairs and containing aggregate bodies (statoliths) have been detected in various species of Vespinae. On the frons in the groove traversing its center (the frontal groove) there is a deep pit and around it a membrane enclosing a cyst-like sac. In...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90833-0
更新日期：1983-04-11 00:00:00
abstract：AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118749
更新日期：2021-01-15 00:00:00
abstract：:The metabolism of phosphoinositides plays an important role in the signal transduction pathways. We report here that naturally occurring polyamines affect the activities of phosphatidylinositol (PI) 3-kinase and PI 4-phosphate (PIP) 5-kinase differently. While polyamines inhibited the PI 3-kinase activity, they stimul...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00320-6
更新日期：1995-01-01 00:00:00
abstract：:This study is aimed to investigate the effect of the prolonged intake of conspicuous amounts of licorice (LE), or its natural constituent glycyrrhizin (G) on murine liver CYP-catalyzed drug metabolism. For this purpose the modulation of the regio- and stereo-selective hydroxylation of testosterone, together with the u...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01154-5
更新日期：1998-01-01 00:00:00
abstract：:The present study was undertaken to examine whether there was a time-dependent change in the toxic effects of amikacin, an aminoglycoside, on renal functions. Male Wistar rats were maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Amikacin (1.2 g/kg) was injected intraperitoneally to a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00647-4
更新日期：1994-01-01 00:00:00
abstract：:We investigated the effects of ketanserin, a S 2 (5-hydroxytryptamine 2; 5-HT 2)-serotonergic receptor antagonist, on cerulein-induced pancreatitis in the rat. Large pharmacological doses of cerulein induced acute pancreatitis in the rat. Ketanserin reduced the cerulein-induced increase in serum amylase concentration ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90476-6
更新日期：1992-01-01 00:00:00
abstract：AIMS:Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM). MAIN METHODS:Senescence-accelerated mice were ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.08.033
更新日期：2012-10-29 00:00:00
abstract：:The lymphatic vessels have been implicated in maintenance of interstitial fluid homeostasis and immune responses, and pathological conditions including inflammation, wound healing, lymphedema and tumor progression. The knowledge about the lymphatic structure and function in muscles, especially in muscular disorders, r...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.09.043
更新日期：2018-10-15 00:00:00
abstract：:The central interference induced by dexamethasone and RU-38486, (a glucocorticoid receptor antagonist) on morphine antinociception were studied by using the tail flick test in mice. Dexamethasone, injected intracerebrally (i.c.v.) 10 minutes before morphine, dose-dependently reduced morphine antinociception, whereas R...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90521-p
更新日期：1992-01-01 00:00:00
abstract：:Previous research in this laboratory has shown that chronic treatment of adult male rats with an anabolic-androgenic steroid (AAS) produced anxiolytic behavior and increased the functional response of cortical gamma-aminobutyric acid(A) (GABA(A)) receptors. The experiments reported here were aimed at further character...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02326-7
更新日期：1996-01-01 00:00:00
abstract：AIMS:Rg1 is the most active component of traditional Chinese medicine ginseng, having anti-aging and anti-oxidative stress features in multiple organs. Cellular senescence of hepatocytes is involved in the progression of a wide spectrum of chronic liver diseases. In this study, we investigated the potential benefits an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117776
更新日期：2020-08-01 00:00:00
abstract：:Free radicals induced by cerebral ischemia-reperfusion injury can trigger lipid peroxidation, leading to the production of malondialdehyde (MDA) and 4-hydroxy-2(E)-nonenal (4-HNE). Post-ischemia electroacupuncture (EA) therapy was able to reduce extent of lipid peroxidation. However, the effect of pre-ischemic EA ther...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.02.025
更新日期：2004-07-30 00:00:00
abstract：:The potential role of exercise in preventing the age-related spontaneous peripheral neuropathy has not been studied. We examined the effects of long-term aerobic exercise training on lipid peroxidation, Schwann cell (SC) apoptosis and ultrastructural changes in the sciatic nerve of rats during aging. Three groups of 1...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.01.018
更新日期：2008-04-09 00:00:00
abstract：:The release of endogenous dopamine (DA) has been measured in the rat striatum following the intracardial administration of various doses of beta-phenylethylamine (PEA) or alpha,alpha-dideutero-beta-phenylethylamine (deuterated PEA). The release was significantly increased for a period of approximately 15 minutes by a ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90480-7
更新日期：1986-12-22 00:00:00
abstract：AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.12.002
更新日期：2017-02-01 00:00:00
abstract：:The chloromethyl ketone derivative of D-Ala2-Leu5-enkephalin was synthesized in a radioactive form, and the resulting compound (3H-DALECK) was used to label opioid receptors. 3H-DALECK binds with high affinity, specificity and saturability to rat brain membranes. The number of sites labeled is 130 fmoles/mg protein. U...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90491-7
更新日期：1987-07-13 00:00:00
