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Mechanisms underlying the supra-maximal thermogenesis elicited by aminophylline in rats.

Abstract：

:Previous studies showed that acute treatment with aminophylline (AMPY) significantly elevated maximum thermogenesis and improved cold tolerance in rats and man in severe cold. However, the exact mechanism by which AMPY enhances thermogenesis was unknown. Rats receiving enprofylline (ENPRO) (1.5 and 15 mg/kg, i.p.), a selective phosphodiesterase inhibitor, failed to show enhanced thermogenesis. In contrast, treatment with a selective adenosine receptor antagonist, 8-phenyltheophylline(8-PT; 2.5 to 10 mg/kg, i.p.), significantly increased (p less than 0.05) thermogenesis and cold tolerance. However, the maximal thermogenic effect by optimal dose of 8-PT (5 mg/kg) was significantly lower than that with optimal dose of AMPY (18.7 mg/kg, i.p.); the deficit could be eradicated by combining optimal 8-PT dose with a low dose of AMPY (1.25 mg/kg), but not with ENPRO. These results indicate that the thermogenic effect of AMPY is not by inhibition of phosphodiesterase but at least partially by antagonism of adenosine receptors. It is also apparent that older mechanisms in addition to adenosine antagonism are also involved in AMPY's thermogenic action.

journal_name

Life Sci

journal_title

Life sciences

authors

Wang LC,Jourdan ML,Lee TF

doi

10.1016/0024-3205(89)90491-8

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

927-34

issue

14

eissn

0024-3205

issn

1879-0631

pii

0024-3205(89)90491-8

journal_volume

44

pub_type

杂志文章

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