Effects of the S2-serotonergic receptor antagonist, ketanserin, on cerulein-induced pancreatitis in the rat.

abstract：:TCDD was assessed as a biological response modifier for increasing MMC cytotoxicity through aryl hydrocarbon receptor (AhR) activation and increasing levels of bioreductive enzymes. Human MCF-7 cells were exposed to TCDD, MMC and combinations thereof under aerobic or hypoxic conditions. Cytotoxicity, enzyme activities...

journal_title：Life sciences

authors： Collier AC,Pritsos KL,Pritsos CA

更新日期：2006-02-23 00:00:00

abstract：:Two groups of individuals, 26 normotensive normolipemic and 37 normotensive hyperlipemic, all without family history of hypertension have been selected in attempt to demonstrate whether Li-Na countertransport of erythrocytes is influenced by plasma and membrane lipid composition. The maximal rate of Li-Na countertrans...

journal_title：Life sciences

authors： Corrocher R,Ferrari S,Bassi A,Guarini P,Bertinato L,Olivieri O,Licia GM,Ruzzenente O,Brugnara C,De Sandre G

更新日期：1987-08-31 00:00:00

abstract：:Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, was administered orally for 12 weeks to male rats with prednisolone-induced osteoporosis. Microdensitometric analysis of a roentgenograph of the femurs revealed that ipriflavone increased the density of the distal metaphysis dose-dependently and tended to incre...

journal_title：Life sciences

authors： Yamazaki I,Shino A,Shimizu Y,Tsukuda R,Shirakawa Y,Kinoshita M

更新日期：1986-03-10 00:00:00

abstract：:Plasma and urinary levels of MHPG were determined in six normal volunteers. Samples were obtained at 3-hour intervals for plasma and at 12-hour intervals for urine. Acrophase, amplitude and period were determined for plasma MHPG levels. A sinusoidal pattern was obtained for diurnal plasma MHPG with a peak at 15:00 hrs...

journal_title：Life sciences

authors： DeMet EM,Halaris AE,Gwirtsman HE,Reno RM

更新日期：1985-11-04 00:00:00

abstract：:Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different exp...

journal_title：Life sciences

authors： Kowluru A,Kowluru RA,Solomon S,Martinez L

更新日期：1992-01-01 00:00:00

abstract：:A recent neuropathological study has reported decreased levels of dynorphin A immunoreactivity in striato-pallidal fibers in the brain of a patient with severe Gilles de la Tourette's syndrome (TS). This observation, taken with the neuroanatomic distribution of dynorphin and its broad range of motor and behavioral eff...

journal_title：Life sciences

authors： Leckman JF,Riddle MA,Berrettini WH,Anderson GM,Hardin M,Chappell P,Bissette G,Nemeroff CB,Goodman WK,Cohen DJ

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bioaccumulate in adipose tissue, disturbing its metabolism and the balance of adipokines, related to obesity. The altering secretion pattern of adipokines from the adipose tissue and the increasing mechanical load in weight-bearing joint...

journal_title：Life sciences

authors： Abella V,Pérez T,Scotece M,Conde J,Pirozzi C,Pino J,Lago F,González-Gay MÁ,Mera A,Gómez R,Gualillo O

更新日期：2016-07-15 00:00:00

abstract：:Retinitis pigmentosa is a very heterogeneous group of retinal degenerations, with multiple genes identified in each mode of inheritance. For autosomal dominant retinitis pigmentosa (ADRP), the most common gene is the rhodopsin (RHO) gene, mutations in which contribute to about 25% of ADRP in Caucasian population. To i...

journal_title：Life sciences

authors： Zhang XL,Liu M,Meng XH,Fu WL,Yin ZQ,Huang JF,Zhang X

更新日期：2006-02-23 00:00:00

abstract：:The lymphatic vessels have been implicated in maintenance of interstitial fluid homeostasis and immune responses, and pathological conditions including inflammation, wound healing, lymphedema and tumor progression. The knowledge about the lymphatic structure and function in muscles, especially in muscular disorders, r...

journal_title：Life sciences

authors： Ji RC

更新日期：2018-10-15 00:00:00

abstract：AIMS:Head and neck squamous cell carcinoma (HNSCC) is an highly aggressive tumor with heterogeneous prognosis. We here report that immune-related genes (IRGs) could effectively distinguish prognostically different HNSCC patients. MATERIALS AND METHODS:MRNA levels of 1333 IRGs that from ImmPort database in HNSCC sample...

journal_title：Life sciences

authors： Yang J,Xie K,Li C

更新日期：2020-09-01 00:00:00

abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...

journal_title：Life sciences

authors： Yu YL,Li NN,Shi MT,Lu HJ

更新日期：2018-09-15 00:00:00

abstract：:An attenuation of adrenergic activity during the inhibition of endogenous angiotensin II formation was evaluated by determining plasma norepinephrine concentration after a single oral administration of captopril compared to that after nifedipine in essential hypertension. Captopril produced a fall in mean arterial pre...

journal_title：Life sciences

authors： Mohara O,Masuyama Y

更新日期：1991-01-01 00:00:00

abstract：:Since hypertension may compromise the ability to withstand hypernatremic dehydration, we investigated the impact of two experimental models of hypertension and pharmacologic normalization of blood pressure on the tolerance to chronic hypernatremic dehydration. In DOCA-salt hypertensive animals and the spontaneously-hy...

journal_title：Life sciences

authors： Trachtman H,del Pizzo R,Sturman J

更新日期：1990-01-01 00:00:00

abstract：:Previous studies with N-terminal fragments of substance P (SP) have suggested the existence of two separate SP receptor populations. SP1 receptors are found in guinea pig ilea and rat colons. SP2 receptors are found in mouse spinal cords and rat salivary glands. We have now found that substitution of Gly9 in substance...

journal_title：Life sciences

authors： Piercey MF,Dobry-Schreur PJ,Masiques N,Schroeder LA

更新日期：1985-02-25 00:00:00

abstract：:Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...

journal_title：Life sciences

authors： Eshleman A,Dunigan C,Shamoo A,Eldefrawi M

更新日期：1995-01-01 00:00:00

abstract：:Elevated total homocysteine concentrations and obesity are both associated with an increased risk of cardiovascular disease. However, previous studies of weight reduction on serum homocysteine concentrations have obtained inconsistent reports. We investigated the effect of folic acid supplementation on serum homocyste...

journal_title：Life sciences

authors： Sheu WH,Chin HM,Lee WJ,Wan CJ,Su HY,Lang HF

更新日期：2005-03-18 00:00:00

abstract：AIMS:Ventilatory disturbance is a fatal side-effect of opioid analgesics. Separation of analgesia from ventilatory depression is important for therapeutic use of opioids. It has been suggested that opioid-induced ventilatory depression results from a decrease in adenosine 3',5'-cyclic monophosphate content in the respi...

journal_title：Life sciences

authors： Kimura S,Ohi Y,Haji A

更新日期：2015-04-15 00:00:00

abstract：AIMS:Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in melanoma. MATERIALS AND METHODS:Expression of circ_00840...

journal_title：Life sciences

authors： Chen Z,Chen J,Wa Q,He M,Wang X,Zhou J,Cen Y

更新日期：2020-02-15 00:00:00

abstract：:Autophagy is an essential cellular mechanism which plays "housekeeping" role in normal physiological processes including removing of long lived, aggregated and misfolded proteins, clearing damaged organelles, growth regulation and aging. Autophagy is also involved in a variety of biological functions like development,...

journal_title：Life sciences

authors： Ravanan P,Srikumar IF,Talwar P

更新日期：2017-11-01 00:00:00

abstract：:Incubation of the nonsteroidal antiestrogen nitromiphene (CI628) with rat cecal content suspension under aerobic or anaerobic conditions resulted in extensive biotransformation, yielding three metabolites, as determined by thin-layer chromatography. These metabolites were not recovered from incubation mixtures contain...

journal_title：Life sciences

authors： Ruenitz PC,Bagley JR

更新日期：1983-09-12 00:00:00

abstract：:The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigat...

journal_title：Life sciences

authors： Watanabe HK,Hoskins B,Ho IK

更新日期：1988-01-01 00:00:00

abstract：:Promoter methylation is an important mechanism of regulating E-cadherin expression. Methylation-specific PCR (MSP) assay was done to evaluate the promoter methylation status of E-cadherin gene in primary tumor samples from 23 cases of Chinese women with invasive ductal breast cancers. Western blotting assay was employ...

journal_title：Life sciences

authors： Hu XC,Loo WT,Chow LW

更新日期：2002-08-09 00:00:00

abstract：AIMS:Antenatal glucocorticoid therapy has been shown to prevent acute diseases including infant respiratory distress syndrome and reduce mortality, although little is known about the effects on cardiac function-related proteins in the fetus or neonate. We investigated whether cardiac function-related proteins were alte...

journal_title：Life sciences

authors： Tsuzuki Y,Takeba Y,Kumai T,Matsumoto N,Mizuno M,Murano K,Asoh K,Takagi M,Yamamoto H,Kobayashi S

更新日期：2009-10-21 00:00:00

abstract：:The interactions of aminoglycoside, 3',4'-dideoxykanamycin B(DKB) with ATP and its related compounds were investigated. ATP, ADP, cyclic AMP and FAD bound to the DKB-conjugated Sepharose 4B column. The binding of DKB to ATP was also confirmed by equilibrium gel filtration. In the acidic pH region, the fluorescence of ...

journal_title：Life sciences

authors： Inaba A,Aramaki Y,Takahashi M,Tsuchiya S

更新日期：1986-10-13 00:00:00

abstract：:The effects of methadone and morphine on fetal behavior were studied following their administration to either the mother (5micrograms/kg/min) or fetus (0.5micrograms/kg maternal wt./min) using the chronically-instrumented pregnant ewe model. Fourteen unanesthetized, unrestrained pregnant ewes between 130-141 days gest...

journal_title：Life sciences

authors： Umans JG,Szeto HH

更新日期：1983-01-01 00:00:00

abstract：:Upregulation of vascular NAD(P)H oxidase has been considered an important source for elevated levels of reactive oxygen species that contribute to several cardiovascular disease states, including the vascular complications of diabetes mellitus. Previous studies have shown that treatment with antioxidants corrects impa...

journal_title：Life sciences

authors： Cotter MA,Cameron NE

更新日期：2003-08-22 00:00:00

abstract：:This study is aimed to investigate the effect of the prolonged intake of conspicuous amounts of licorice (LE), or its natural constituent glycyrrhizin (G) on murine liver CYP-catalyzed drug metabolism. For this purpose the modulation of the regio- and stereo-selective hydroxylation of testosterone, together with the u...

journal_title：Life sciences

authors： Paolini M,Pozzetti L,Sapone A,Cantelli-Forti G

更新日期：1998-01-01 00:00:00

abstract：:3-methylglutaconic (MGT), 3-methylglutaric (MGA) and occasionally 3-hydroxyisovaleric (OHIVA) acids accumulate in a group of diseases known as 3-methylglutaconic aciduria (MGTA). Although the clinical presentation of MGTA is mainly characterized by neurological symptoms, the mechanisms of brain damage in this disease ...

journal_title：Life sciences

authors： Leipnitz G,Seminotti B,Amaral AU,de Bortoli G,Solano A,Schuck PF,Wyse AT,Wannmacher CM,Latini A,Wajner M

更新日期：2008-03-12 00:00:00

abstract：:Preconditioning (PC) is a potential approach to myocardial protection. We hypothesize that brief ischemia or adenosine given prior to an extended period of warm ischemia may prevent myocardial stunning by altering myocardial metabolism. Using a global ischemia model, 19 dogs were subjected to no PC(control), two episo...

journal_title：Life sciences

authors： Phillips AB,Ko W

更新日期：2007-10-13 00:00:00

abstract：AIMS:Schisandra is a good choice in Traditional Chinese Medicine for the therapy of cardiovascular diseases, but whether it contains a or some specific component (s) responsible these effects are still unclear. In the present study, we explored whether Schisantherin A (SCA) causes vasorelaxation in isolated rat thoraci...

journal_title：Life sciences

authors： Yang S,Xu Z,Lin C,Li H,Sun J,Chen J,Wang C

更新日期：2020-03-15 00:00:00